A5042095889- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Bipolar Disorder and Treatment
- Pregnancy and preeclampsia studies
- Autoimmune and Inflammatory Disorders Research
- Eating Disorders and Behaviors
- Gestational Diabetes Research and Management
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Schizophrenia research and treatment
- Mental Health Research Topics
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Cerebral Palsy and Movement Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- GDF15 and Related Biomarkers
- Vitamin D Research Studies
Karolinska University Hospital
2014-2024
Karolinska Institutet
2014-2024
Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number schizophrenia and bipolar disorder type I, compared to healthy controls. However, it is unknown if mtDNA alteration driven by psychosis, comorbidity or treatment. Whole blood was determined 594 psychosis patients corrected for platelet count ratio (mtDNAcnres). The dependence mtDNAcnres on clinical profile, metabolic...
Hypertensive disorders of pregnancy (HDP) or prepregnancy overweight/obesity are independently associated with the risk for certain neurodevelopmental and psychiatric in offspring. These two conditions often co-exist but from combined exposure is unknown. We investigated whether specific subtypes maternal HDP, along overweight/obesity, were distinct offspring during childhood. This prospective, population-based cohort study used data 652 732 singleton children born alive Finland between 2004...
Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer inflammatory disorders. Recently, elevated serum level was proposed marker mood disorder. However, psychosis severity not investigated in relation to plasma levels. In the present study we measured levels 120 patients compared age gender matched healthy controls. Within patient cohort were evaluated association with age, gender, lifestyle factors, C-reactive protein...
Mobility disability (MD) refers to substantial limitations in life activities that arise because of movement impairments. Although MD is most prevalent older individuals, it can also affect younger adults. Increasing evidence suggests inflammation drive the development and may need be targeted for prevention. Physical exercise has anti-inflammatory properties been associated with However, no studies date have examined whether interventions peripheral inflammatory status adults MD. To this...
Cortisol hypersecretion plays a role in depression pathophysiology. Internet-based cognitive behavioural therapy (ICBT) and physical exercise (PE) are new treatment alternatives for depression, their long-lasting effect on cortisol is unknown. We investigated level changes after 12 weeks of ICBT, PE or as usual (TAU).The present pre-post repeated measure study analysed data derived from randomised controlled trial evaluating the effects weeks' interventions TAU depressed primary care...