A5002856500- Transgenic Plants and Applications
- Animal Disease Management and Epidemiology
- Cervical Cancer and HPV Research
- Microbial infections and disease research
- Virus-based gene therapy research
- Animal Virus Infections Studies
- T-cell and Retrovirus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Vector-Borne Animal Diseases
- Plant Virus Research Studies
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Animal Genetics and Reproduction
- Ethics and bioethics in healthcare
- Immunotherapy and Immune Responses
- Vector-borne infectious diseases
- Mycotoxins in Agriculture and Food
- Bacteriophages and microbial interactions
- Toxin Mechanisms and Immunotoxins
- Biochemical and Structural Characterization
- Hepatitis B Virus Studies
- Antimicrobial Peptides and Activities
Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso
2023
Universidade Federal de Pernambuco
2011-2021
Universidade Federal Rural de Pernambuco
2016-2020
Human papillomavirus (HPV) infection is the most common sexually transmitted disease in world and related to etiology of cervical cancer. The high-risk HPV types are 16 18; however, second prevalent type Midwestern region Brazil HPV-33. New vaccine strategies against have shown that virus-like particles (VLP) major capsid protein (L1) induce efficient production antibodies, which confer protection same viral type. methylotrophic yeast Pichia pastoris an inexpensive expression system for high...
Papillomavirus (PV) are double-stranded DNA viruses that can cause both benignant and malignant tumours in mammals. Twelve genotypes of bovine papillomavirus (BPV1–12) have been identified so far. The presence BPV1 2 has found the body fluids cattle horses. aim this study is to investigate BPV expression viral genes blood sperm cells healthy horses using PCR RT-PCR. BPV-1 or was detected 14 70 samples (20%) 11 31 semen (35%). In five fourteen samples, E5 tested positive, while no sample...
The human papillomavirus (HPV) L1 major capsid protein, which forms the basis of currently available vaccines against cervical cancer, self-assembles into virus-like particles (VLPs) when expressed heterologously. We report development a biotechnology platform for HPV16 protein expression based on constitutive PGK1 promoter (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Porcine circovirus 2 (PCV2) is a common virus in pig population and associated with the postweaning multisystemic wasting disease (PMWS). In this study, it was developed evaluated single-tube nested PCR (STNPCR) method for detection of PCV2 DNA. reference controls swine tissue samples were used, primers selected targeting specific regions viral genome. comparison methods, STNPCR 10 times more sensitive than conventional showed same sensitivity to (NPCR), but reduction risk...
Improving antigen presentation is crucial for the success of immunization strategies. Yeasts are classically used as biofactories to produce recombinant proteins and efficient vehicles delivery, in addition their adjuvant properties. Despite absence epidemic outbreaks, several vaccine approaches continue be developed Zika virus infection. The development these prophylactic strategies fundamental given severity clinical manifestations, mainly due viral neurotropism. present study aimed...
Papillomaviruses are known to cause benign or malignant lesions in various animals.In cattle, bovine papillomavirus (BPV) is the etiologic agent of papillomatosis and neoplasia upper gastrointestinal tract urinary bladder.Currently, there no standard diagnostic tests prophylactic vaccines.Protection against infection conferred by neutralizing antibodies directed towards major structural protein L1.These can be efficiently induced immunization with virus-like particles that formed...
Papillomaviruses are known to cause tumor lesions, generally benign, in epithelial tissues of diverse organisms; these lesions may progress cancer under suitable conditions. Bovine papillomavirus (BPV) can urinary bladder and the upper gastrointestinal tract. Furthermore, BPV1 BPV2 implicated development tumors equids. Many studies with animal models clearly demonstrate that DNA vaccines very effective tools controlling viral infections, providing strong humoral cellular immune responses. In...
Improving antigen presentation is crucial for the success of immunization strategies. Yeasts are classically used as biofactories to produce recombinant proteins and efficient vehicles delivery vaccine antigens, besides present adjuvants properties. Despite absence epidemic outbreaks, several approaches continue be developed Zika virus infection. These prophylactic strategies fundamental given severity clinical manifestations, mainly due viral neurotropism. The study aimed evaluate in vivo...