A5000522948- Veterinary Oncology Research
- Cervical Cancer and HPV Research
- Virus-based gene therapy research
- Microbial infections and disease research
- Bladder and Urothelial Cancer Treatments
- Animal Disease Management and Epidemiology
- Cancer Research and Treatments
- Oral and Maxillofacial Pathology
- Poxvirus research and outbreaks
- T-cell and Retrovirus Studies
- Infectious Diseases and Mycology
- Inflammatory mediators and NSAID effects
- Heat shock proteins research
- Herpesvirus Infections and Treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Protease and Inhibitor Mechanisms
- Mast cells and histamine
- Milk Quality and Mastitis in Dairy Cows
- Hedgehog Signaling Pathway Studies
- Reproductive Physiology in Livestock
- Cancer and Skin Lesions
- Periodontal Regeneration and Treatments
- Cancer, Hypoxia, and Metabolism
- Plant Toxicity and Pharmacological Properties
University of Naples Federico II
2015-2024
University of Sassari
2011
University of Veterinary Medicine
2011
University of Milan
2011
Regione Campania
2010
Federico II University Hospital
2010
University of Cambridge
2010
Cambridge University Press
2010
Bovine papillomavirus type 2 (BPV-2) infection has been associated with urinary bladder tumours in adult cattle grazing on bracken fern-infested land. In this study, we investigated the simultaneous presence of BPV-2 whole blood and an attempt to better understand biological role circulating BPV-2. Peripheral samples were collected from 78 clinically suffering a severe chronic enzootic haematuria. Circulating DNA was detected 61 them two healthy cows. Fifty affected animals slaughtered at...
Summary Cryopreservation of gametes is an important tool in assisted reproduction programmes; long-term storage oocytes or spermatozoa necessary when vitro fertilization (IVF) artificial insemination to be performed at a future date. epididymal offers potential for rescuing genetic material from males endangered populations. The objectives this work were to: (1) examine sperm motility, viability, abnormality and acrosome integrity frozen–thawed domestic cat spermatozoa; (2) evaluate the same...
Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara Black Sea Regions Turkey. BPV-2 DNA found both neoplastic non-neoplastic lesions bladder. Furthermore, this virus may be normal inhabitant since also detected clinically buffaloes. The viral activation by fern immunosuppressant or carcinogen trigger urothelial cell transformation. E5 oncoprotein was solely tumours appeared...
Papillomaviruses (PVs) are believed to be highly epitheliotropic as they usually establish productive infections within stratified epithelia. In vitro, various PVs appear complete their entire life-cycle in different trophoblastic cell lines. this study, infection by and protein expression of bovine papillomavirus type 2 (BPV-2) the uterine chorionic epithelium placenta has been described four cows suffering from naturally occurring papillomavirus-associated urothelial bladder tumors. E5...
Samples of neoplastic and normal urothelium were obtained from cows originating areas southern Italy, a region in which chronic enzootic haematuria is endemic bracken fern infestation widespread. Specimens analysed for bovine papillomavirus type 2 (BPV-2) DNA, BPV-2 E5 expression telomerase activity. A total 46 60 tumours 17 34 bladder mucosa samples harboured DNA. Analysis subset showed protein activity tumour tissue only. No positive BPV DNA or activity, suggesting the presence latent...
Bovine papillomavirus type 2 (BPV-2) is an oncogenic virus infecting both epithelial and mesenchymal cells. Its life cycle, similar to other papillomaviruses (PVs), appears be linked differentiation. Human bovine PVs have been known reside in a latent, episomal form PBMCs; therefore, it believed that blood cells, like all function as non-permissive carriers. Here, for the first time veterinary comparative medicine, BPV-2 E5 oncoprotein major structural L1 capsid protein, expressed only...
Papillomas and fibropapillomas may occur in the skin different organs animals. Ten genotypes of bovine papillomavirus (BPV) have been identified. BPV-1 through BPV-10 are all strictly species-specific, but BPV-1/2 also infect other species such as equids, inducing fibroblastic tumors. BPV-2 associated with cattle; these tumors formed by excessive proliferation virus-infected dermal fibroblasts epidermal keratinocytes. Nine water buffalo (Bubalus bubalis) were examined for presence multiple...
Abstract Bovine papillomaviruses (BPVs) are oncogenic DNA viruses, which mainly induce benign lesions of cutaneous and/or mucosal epithelia in cattle. Thirteen (BPV 1–13) different viral genotypes have been characterized so far. BPVs usually species-specific but BPV 1/2 may also infect equids as well buffaloes and bison cause tumors these species. BPV-induced regress, however occasionally they develop into cancer particularly the presence environmental carcinogenic co-factors. The major...
Expression of telomerase reverse transcriptase (TERT) and activity (TA) is a main feature cancer, contributing to cell immortalization by causing telomeres dysfunction. BIBR1532 potent inhibitor that showed potential anti-tumor activities in several types triggering replicative senescence apoptosis. In previous work, we detected, for the first time, TERT expression TA preclinical models feline oral squamous carcinoma (FOSCC); therefore, aimed at extending our investigation testing effects...
Bovine papillomavirus types 1 and 2 (BPV-1 BPV-2) are known to induce common equine skin tumours, termed sarcoids. Recently, it was demonstrated that vaccination with BPV-1 virus-like particles (VLPs) is safe highly immunogenic in horses. To establish a challenge model for evaluation of the protective potential VLPs, four foals were injected intradermally infectious virions viral genome-based control inocula, monitored daily tumour development. Blood taken before inoculation at weekly...
Papillomaviruses are a family of slowly evolving DNA viruses and their evolution is commonly linked to that host species. However, whilst bovine papillomavirus-1 (BPV-1) primarily causes warts in its natural host, the cow, it can also cause locally aggressive invasive skin tumours equids, known as sarcoids, thus provides rare contemporary example cross-species transmission papillomavirus. Here, we describe first phylogenetic analysis BPV-1 equine sarcoids our knowledge, allowing us explore...
Abstract E6 from high risk human papillomaviruses (HR HPVs) promotes ubiquitination and degradation of p53 tumour suppressor by mediating its binding to ubiquitin ligase E6AP in a ternary complex, contributing cell transformation cervical cancer. We have previously shown that Felis catus papillomavirus type −2 (FcaPV-2) is expressed feline squamous carcinoma (SCC) displays the ability bind decrease protein levels transfected CRFK cells. However, mechanism downregulation has not yet been...
Background Calpain 3 (Capn3), also named p94, is a skeletal muscle tissue-specific protein known to be responsible for limb-girdle muscular dystrophy type 2A (LGMD2A). Recent experimental studies have hypothesized pro-apoptotic role of Capn3 in some melanoma cell lines. So far the link between calpain3 and tumors comes from vitro studies. The objective this study was describe activation naturally occurring urothelial urinary bladder cattle. Methods Findings Here we describe, first time...
Abstract Papillomavirus (PV) infection is associated with development of epithelial cancer in different species, including domestic cat ( Felis catus ). PV type‐2 (FcaPV‐2) considered the causative agent a proportion feline cutaneous squamous cell carcinoma (SCC), through transforming properties its E6 and E7 oncogenes. However, possible role FcaPVs aetiology oral SCC (FOSCC) still unclear. The aim this study was to assess presence gene expression FcaPV‐2 FOSCC samples. We detected DNA 10/32...