A5022745113- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- Bone fractures and treatments
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Bone health and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Hedgehog Signaling Pathway Studies
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Glioma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Natural Antidiabetic Agents Studies
- Cancer Immunotherapy and Biomarkers
- Connective tissue disorders research
- Knee injuries and reconstruction techniques
- TGF-β signaling in diseases
- Heterotopic Ossification and Related Conditions
- Venomous Animal Envenomation and Studies
- Osteoarthritis Treatment and Mechanisms
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
Eli Lilly (United States)
2024-2025
Loxo Oncology at Lilly (United States)
2024
Indiana University School of Medicine
2014-2023
Indiana University – Purdue University Indianapolis
2014-2023
Indiana University
2018-2020
University School
2020
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. Although CNS activity of selpercatinib patients with RET fusion-positive non–small cell lung cancer (NSCLC)...
Approximately 10% of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient healing. Inhibition Ca
Fracture risk in type 2 diabetes is increased despite normal or high bone mineral density, implicating poor quality as a factor. Raloxifene improves material and mechanical properties independent of density. This study aimed to determine if raloxifene prevents the negative effects on skeletal fragility diabetes-prone rats. Adult Zucker Diabetic Sprague-Dawley (ZDSD) female rats (20-week-old, n = 24) were fed diabetogenic high-fat diet randomized receive daily subcutaneous injections vehicle...
Calcium/calmodulin (CaM)-dependent protein kinase 2 (CaMKK2) regulates bone remodeling through its effects on osteoblasts and osteoclasts. However, role in osteocytes, the most abundant cell type master regulator of remodeling, remains unknown. Here we report that conditional deletion CaMKK2 from osteocytes using Dentine matrix 1 (Dmp1)-8kb-Cre mice led to enhanced mass only female owing a suppression Conditioned media isolated CaMKK2-deficient inhibited osteoclast formation function vitro...
Bone fractures impose a tremendous socio-economic burden on patients, in addition to significantly affecting their quality of life. Therapeutic strategies that promote efficient bone healing are non-existent and high demand. Effective reproducible animal models needed understand the complex biological processes associated with regeneration. Many fracture have been generated over years; however, murine recently emerged as powerful tools study healing. A variety open closed developed, but...
Approximately 5% to 10% of all bone fractures do not heal completely, contributing significant patient suffering and medical costs. Even in healthy individuals, fracture healing is associated with downtime loss productivity. However, no pharmacological treatments are currently available promote efficient healing. A better understanding the underlying molecular mechanisms crucial for developing novel therapies hasten The early reparative callus that forms around site injury a fragile tissue...
Bone fractures impose a tremendous socio-economic burden on patients, in addition to significantly affecting their quality of life.Therapeutic strategies that promote efficient bone healing are non-existent and high demand.Effective reproducible animal models needed understand the complex biological processes associated with regeneration.Many fracture have been generated over years; however, murine recently emerged as powerful tools study healing.A variety open closed developed, but femoral...
8547 Background: Selpercatinib is a highly selective and potent CNS active RET inhibitor approved for treatment of advanced fusion-positive ( RET+) NSCLC. Treatment or prevention disease critical in RET+ NSCLC patients (pts), who have nearly 50% lifetime prevalence brain metastases (mets) (Drilon et al. JTO 2018). LIBRETTO-431 the first study to compare intracranial (IC) efficacy targeted therapy chemo/IO pts with oncogene driven Methods: (NCT04194944) randomized, open-label, phase 3 trial...
199 Background: Selpercatinib is a highly selective and potent CNS active RET inhibitor approved for treatment of advanced fusion-positive ( RET+) NSCLC. Treatment or prevention disease critical in RET+ NSCLC patients (pts), who have nearly 50% lifetime prevalence brain metastases (mets) (Drilon et al. JTO 2018). LIBRETTO-431 the first study to compare intracranial (IC) efficacy targeted therapy chemo/IO pts with oncogene driven Methods: (NCT04194944) randomized, open-label, phase 3 trial...
Background and Hypothesis: The Ca+2/calmodulin (CaM)-mediated protein kinase 2 (CaMKK2) is a multi-functional with effects on cell proliferation, differentiation metabolism. role of CaMKK2 in bone has been explored its ablation favoring osteoblasts to osteoclasts mass accrual as observed Camkk2-/- mice, or following inhibition by STO-609. One outstanding question whether the anabolic are bone-cell intrinsic. While analyzing mice harboring specific deletion CaMKK2, we high phenotype when...
Background and Hypothesis: Ca2+/calmo-dulin-dependent protein kinase 2 (CaMKK2) is a serine-threonine that plays significant role in both anabolic catabolic pathways of bone remodeling. Mechanical loading translates an external force into biochemical structural changes. It has been shown deletion or inhibition CaMKK2 results increased density male female mice. We hypothesize the lack cells will result loading-induced mass accrual with no difference between Experimental Design Project...