Giulia Sorgentoni
A5043506279- Mesenchymal stem cell research
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Breast Implant and Reconstruction
- Psoriasis: Treatment and Pathogenesis
- Multiple and Secondary Primary Cancers
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- PI3K/AKT/mTOR signaling in cancer
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Spine and Intervertebral Disc Pathology
- 3D Printing in Biomedical Research
- Ferroptosis and cancer prognosis
University of Macerata
2019-2024
Ospedale di Macerata
2019-2024
Marche Polytechnic University
2015-2021
Abstract Background Immune checkpoint inhibitors have changed previous treatment paradigm of advanced urothelial carcinoma (UC). The ARON-2 study (NCT05290038) aimed to assess the real-world effectiveness pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. Patients and Methods Medical records with documented metastatic UC treated by as second-line therapy were retrospectively collected from 88 institutions 23 countries. assessed for overall survival (OS),...
Abstract Psoriasis is a disease characterized by an imbalance between Th 1 and 17 2 inflammatory axes, in which cutaneous mesenchymal stem cells ( MSC s) are early involved, as they show greater relative expression of several genes encoding for cytokines. Therapeutic implications TNF ‐α inhibitors on differentiated skin have been largely described psoriasis; however, their effects s derived from patients with psoriasis only partially described. The aim this work was to evaluate the effect...
Alzheimer’s disease (AD), the most prevalent neurodegenerative in growing population of elderly people, is still lacking minimally-invasive circulating biomarkers that could facilitate diagnosis and monitoring progression. MicroRNAs (miRNAs) are emerging as tissue-specific and/or several age-related diseases, but evidence on AD not conclusive. Since a systemic pro-inflammatory status was associated with an increased risk development progression, we focused our investigation subset miRNAs...
Psoriasis microenvironment, characterized by an imbalance between T helper type 1 (Th1)/Th17 and Th2 cytokines also influences the mesenchymal stem cells (MSCs) phenotypical profile. MSCs from healthy donors (H-MSCs) can exert a strong paracrine effect secreting active soluble factors, able to modulate inflammation in microenvironment. To evaluate influence of H-MSCs on psoriatic patients (PsO-MSCs), PsO-MSCs were isolated characterized. Indirect co-culture with was performed; effects...
The upfront treatment of metastatic renal cell carcinoma (mRCC) has been revolutionized by the introduction immune-based combinations. role cytoreductive nephrectomy (CN) in these patients is still debated. ARON-1 study (NCT05287464) was designed to globally analyze real-world data mRCC receiving first-line immuno-oncology This sub-analysis focused on or delayed partial radical CN three geographical areas (Western Europe, Eastern America/Asia).We conducted a multicenter retrospective...
Cabozantinib is approved for the treatment of renal cell carcinoma (RCC). However, prognostic factors are still lacking in this context. The aim study was to evaluate RCC patients treated with second- or third-line cabozantinib. A multicenter retrospective real-world conducted, involving 32 worldwide centers. total 237 histologically confirmed clear-cell and non-clear-cell who received cabozantinib as therapy metastatic disease were included. We analyzed overall survival (OS),...
<h3>Importance</h3> Hidradenitis suppurativa (HS) is a disease of the terminal hair follicle in apocrine gland–enriched skin areas, where immunobiology dysregulation mesenchymal stem cells (MSCs) may have key role. <h3>Objective</h3> To investigate MSC profile patients with HS and healthy controls. <h3>Design, Setting, Participants</h3> In this prospective case-control study, were recruited from Dermatological Clinic at Department Clinical Molecular Sciences, Università Politecnica delle...
We analyzed the clinical and pathological features of renal cell carcinoma (RCC) patients treated with cabozantinib stratified by body mass index (BMI). retrospectively collected data from 16 worldwide centers involved in treatment RCC. Overall survival (OS) progression-free (PFS) were using Kaplan–Meier curves. Cox proportional models used at univariate multivariate analyses. 224 advanced RCC receiving as second- (113, 5%) or third-line (111, therapy. The median PFS was significantly higher...
CDK4/6 inhibitors (CDK4/6i) with endocrine therapy (ET) represent the milestone of first-line in hormone receptor-positive (HR+) HER2-negative (HER2-) metastatic breast cancer (mBC). Aim our retrospective study was to identify new prognostic factors this setting. All patients (pts) affected by HR+/HER2- mBC referred Institutions from February 2017 August 2023 and treated CDK4/6i + ET as setting were included. 220 pts Neutropenia occurred 95.5% pts, causing 38.2% dose reduction 4.1%...