Summary Backgrounds and aim Microglial cells as an important part of central nervous system ( CNS ) have generally believed to play significant role in the process leading a number neurodegenerative disorders including Parkinson's disease, A lzheimer's prion diseases, multiple sclerosis, HIV ‐dementia, stroke. Although different diseases quite pathogenesis, activation microglia was shared with all them. Recently, resolvin D1 R v D 1) endogenous antiinflammatory lipid mediator has been...

Liver resection or enucleation has been the basic treatment for liver hemangioma. However, there were few reports about laparoscopic surgery (LS) of The intention this study is to explore indication and efficacy LS hepatectomy (LH) develop an opinion these modern developments.Forty-four patients with LH underwent LS, hemihepatic vascular occlusion (HVO group n = 24) modified (MVO 20), retrospectively reviewed, including patients' demography, surgical technique, tumor size location, blood...

To study the effect of H2 gas on liver injury in massive hepatectomy using intermittent Pringle maneuver swine.Male Bama pigs (n = 14) treated with ketamine hydrochloride and Sumianxin II as induction drugs followed by inhalation anesthesia 2% isoflurane, underwent 70% hepatotectomy loss bleeding less than 50 mL, hepatic pedicle occlusion for 20 min, were divided into two groups: Hydrogen-group 7), hydrogen tracheal intubation during major hepatotectomy; contrast-group without hydrogen....

The aim of this study was to evaluate the association between activating enhancer binding protein 4 (AP-4) tissue expression and patient prognosis in hepatocellular carcinoma (HCC). levels AP-4 mRNA tumor para-tumor were evaluated 30 HCC cases by quantitative real-time polymerase chain reaction (qRT-PCR) Western blot. Additionally, 112 analyzed immunohistochemistry. correlation patients' clinicopathological parameters evaluated. Survival analysis performed using Kaplan-Meier method Cox's...

MicroRNA (miRNA) is a type of short non-coding RNA that suppresses the expression protein coding genes by partial complementary binding to 3'‑untranslated regions (UTRs) mRNAs. miRNA alterations are involved in initiation, progression and metastasis human cancer it has been suggested miRNAs function as tumor suppressors well oncogenes development. PIM-3 member proto-oncogene PIM family, aberrant which exists pancreatic tissues. There reports indicating overexpression PIM3 associated with...

The molecular regulation of growth hepatocellular carcinoma (HCC) is yet to be fully clarified. Here we found a significantly higher ratio phosphorylated β-catenin (phos-β-cat) (β-cat) as an indicator activated Wnt signaling, with levels c-myc and transcription factor activating protein-4 (AP-4) lower level p21 in the resected HCC, compared paired adjacent healthy hepatic tissue from patients. Moreover, strong correlations were detected between phos-β-cat/β-cat level, AP-4 levels, levels....

The current study explored the effects of intensive insulin therapy (IIT) combined with low molecular weight heparin (LMWH) anticoagulant on severe acute pancreatitis (SAP). A total 134 patients SAP that received treatment between June 2008 and 2012 were divided randomly into groups (control; n=33), B (IIT; C (LMWH; n=34) D (IIT + LMWH; n=34). Group treated routinely. continuous pumped insulin, as well routine treatment, to maintain blood sugar level 4.4 6.1 mmol/l. a subcutaneous injection...

Background. Both splenectomy (SP) and partial splenic embolization (PSE) are used to treat massive splenomegaly (MSM) secondary hepatitis B-related liver cirrhosis (HB-LC). This retrospective case-control study was conducted compare the effects of SP PSE on these patients. Methods. From July 2004 January 2012, patients with MSM HB-LC who underwent or were 1 : matched similar nonsurgery patients, respectively. Intraoperative situation, hematological indices, function, HBV DNA level, HBeAg...

Background: To date, several clinical trials have demonstated that both one-stage laparoscopic cholecystectomy (LC) combined with common bile duct exploration (LC+BDE) primary closure and LC endoscopic stone extraction (LC+ESE) are the two approaches to treat cholelithiasis. However, no studies date directly compared LC+BDE LC+ESE procedures. We, therefore, conducted a retrospective analysis of patients cholelithiasis who had been treated through or compare these for treatment cholecystitis...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death worldwide. Although great progress in diagnosis and management HCC have been made, exact molecular mechanisms remain poorly understood. The study aims to identify potential biomarkers for progression, mainly at transcription level. In this study, chip data GSE 29721 was utilized, which contains 10 samples normal adjacent tissue samples. Differentially expressed genes (DEGs) between two sample types were...

AIM:To investigate the feasibility of temporary extracorporeal continuous porta-caval diversion (ECPD) to relieve portal hyperperfusion in "small-for-size" syndrome following massive hepatectomy pigs.

During liver resection, bleeding remains the most important challenge. A reduction in blood loss and avoiding need for a transfusion are objectives surgeons today. The authors compared intra- postoperative course of patients undergoing laparoscopic resections under intermittent total pedicle occlusion (IPO), hemihepatic vascular (HVO), selective (SVO).Retrospective analysis was conducted patient data from 41 cases resection three groups different methods, including 15 IPO, HVO, 11 SVO....

Background: A recent meta-analysis showed that the primary closure (PC) of biliary duct in absence T-tube (TT) drainage is a safe alternative for cholelithiasis after laparoscopic exploration. However, its feasibility, benefits, and indications hepatolithiasis remain undefined. Patients Methods: From October 2008 to 2012, we enrolled 84 patients with intrahepatic bile stones who underwent exploration (LBDE) and/or hepatectomy TT-drainage or PC. The operative outcomes, intraoperative...

There is no consensus for laparoscopy first in patients with rectal cancer and synchronous liver metastases, whose metastases are confined to the liver. This study aimed evaluate its indications one-stage surgery laparoscopy.Eighteen who had undergone laparoscopic colorectal resection simultaneous treatment were retrospectively reviewed.Concomitant resection, eight received simultaneously; 10 underwent a variety of down-staging management including local ablation, right hepatic portal vein...

In laparoscopic distal pancreatectomy, the stapler transection of pancreas remains preferred method; however, pancreatic fistula continues to be a critical unsolved problem. The aim this study was compare complications associated with especially regarding formation fistula, particular attention and hand-sewn closure technique.Between January 2004 June 2012, 47 patients underwent pancreatectomy. These patient's bodies were similar, they subjected stump either by (Staple group, n=21) or...

This study is aimed at assessing the safety and feasibility of laparoscopic total mesorectal excision (LTME) combined with improved Bacon (IB) procedure in treatment lower rectal cancer. There were 347 patients undergoing sphincter-preserving operation authors hospital from 2003 to 2009. Of these, there 201 cases double stapler technique (DST) anastomosis high-location group (range 6 12cm); 76 DST low-location subgroup A 5 6cm); 70 IB B 6cm). In vs. A, anastomotic leak rate covering stoma...

To study the feasibility and safety of laparoscopic spleen-preserving distal pancreatectomy (LSPDP).Four patients underwent attempted LSPDP from February 2008 to April 2010 in our department their clinical data outcome were reviewed retrospectively.A total 4 pancreas resections for 3 female 1 male patient. All these operations successful with an average operative time 235 min (range 115-305 min) blood loss 200mL 100-450mL). The mean hospital stay was 12.8 days, ranging 10 21 days. Pancreatic...

Purpose: The parenchymal transection and bleeding are important problems in laparoscopic hepatectomy (LH). study aimed to evaluate the feasibility safety of LH for a malignant hepatic tumor (MHT) with vascular occlusion (HVO) only using monopolar electrocautery. Methods: A total 31 patients’ profiles, operative data, clinical outcomes, pathologic findings, follow-up information were collected who underwent HVO. Results: median time was 176 minutes postoperative hospital stay 9 days....