A5001631189- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Autopsy Techniques and Outcomes
- COVID-19 and healthcare impacts
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Bone health and treatments
- CAR-T cell therapy research
- Metabolism, Diabetes, and Cancer
- Vector-borne infectious diseases
- Clinical Reasoning and Diagnostic Skills
- Innovations in Medical Education
- Innovative Teaching Methods
- Inflammatory Myopathies and Dermatomyositis
- Ophthalmology and Visual Health Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- T-cell and B-cell Immunology
- Thyroid Cancer Diagnosis and Treatment
- Patient Safety and Medication Errors
- Internet Traffic Analysis and Secure E-voting
Orlando Health
2020-2024
Oxford University Hospitals NHS Trust
2018-2024
University of Central Florida
2020-2023
Florida College
2020-2023
AdventHealth Kissimmee
2023
University of Oxford
2019-2022
Osceola Regional Medical Center
2020-2022
Buckinghamshire Healthcare NHS Trust
2020
Polk County Public Schools
2020
CRUK/MRC Oxford Institute for Radiation Oncology
2020
Digital pathology and image analysis potentially provide greater accuracy, reproducibility standardisation of pathology-based trial entry criteria endpoints, alongside extracting new insights from both existing novel features. Image has great potential to identify, extract quantify features in detail comparison pathologist assessment, which may produce improved prediction models or perform tasks beyond manual capability. In this article, we an overview the utility such technologies clinical...
To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and assess whether the TIL counts correlate with relapse status patient.TILs were manually annotated 259 tumour regions from 28 whole-slide images (WSIs) H&E-stained samples. A was on half tested other half. The further applied larger areas WSIs 89 patients correlated clinicopathological data.A correlation coefficient 0.89 achieved when...
We describe three cases of critical acute myositis with myocarditis occurring within 22 days each other at a single institution, all 1 month receiving the initial cycle anti-PD-1 drug pembrolizumab. Analysis T cell receptor repertoires from peripheral blood and tissues revealed high degree clonal expansion public clones between cases, several expanded skeletal muscle putatively recognizing viral epitopes. All patients had recently received COVID-19 mRNA booster vaccine prior to treatment...
Abstract Background Disaster medicine is a growing field within the specialty of emergency medicine, but educational training typically focuses on hospital drills or other strategies, such as didactics, simulation, tabletop exercises. With success gamification in medical education applications, we sought to investigate if novel gamified curricular innovation would lead improved test performance and confidence ability manage real mass casualty incident (MCI). Methods This was prospective...
Indirect increases in morbidity and mortality resulting from movement restrictions imposed during the COVID-19 pandemic have been identified as a public health concern.1Banerjee A Pasea L Harris S et al.Estimating excess 1-year associated with according to underlying conditions age: population-based cohort study.Lancet. 2020; 395: 1715-1725Summary Full Text PDF PubMed Scopus (322) Google Scholar Deaths registered England Wales exceeded 5-year average by almost 50 000 first 2 months of...
The COVID-19 viral infection, caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a currently ongoing global pandemic that, as of mid-October, 2020, has resulted in more than 38.7 million confirmed cases globally and 1.1 fatalities. infection associated with life threatening cardiac complications such distress (ARDS), pneumonia, shock, arrhythmias, myocardial infarction heart failure, particularly infectious stage. Acute myopericarditis another...
Abstract Approximately 75% of bladder cancers are non‐muscle invasive (NMIBC). Of these, up to 53% cases progress life‐threatening muscle‐invasive cancer (MIBC). Patients with high‐grade stage T1 (HGT1) NMIBC frequently undergo radical cystectomy (RC), although this represents overtreatment for many. Identification progressors versus non‐progressors could spare unnecessary treatment. Recent studies have confirmed that urothelial carcinoma is composed two main molecular subtypes, basal and...
The fifth generation core network (5GC) introduces a range of new technologies and an architectural overhaul to expand service capability provide wide performance enhancements. introduction flexible, configurable open also introduce variety attack vectors. Core Network Functions (NF) critical services allow the operate correctly efficiently but these can be accessed by adversaries for malicious purposes. A crucial role in securing involves providing effective access control challenging...
Widespread disruption of healthcare services and excess mortality not directly attributed to COVID-19 occurred between March May 2020. We undertook the first UK multicentre study coroners' autopsies before during this period using postmortem reports.We reviewed reports non-forensic performed lockdown (23 8 2020), same in 2018. Deaths were categorised as natural non-COVID-19, COVID-19-related, non-natural (suicide, drug alcohol-related, traumatic, other). provided opinion regarding whether...
Complement-mediated hemolytic uremic syndrome (CM HUS) is a rare but potentially devastating disease that results in intravascular hemolysis and thrombocytopenia, precipitating severe end-organ damage. CM HUS specific disorder under the collective group of thrombotic microangiopathies along with thrombocytopenic purpura (TTP). Pregnancy itself can be precipitant HUS, although rare, due to dysregulated complement activation. Typical pregnancy induces elevated activation effect equal elevation...
Abstract We describe three cases of critical acute myositis with myocarditis occurring within 22 days each other at a single institution, all one month receiving the initial cycle anti-PD-1 drug Pembrolizumab. Analysis T cell receptor repertoires from peripheral blood and tissues revealed high degree clonal expansion public clones between cases, several expanded skeletal muscle putatively recognising viral epitopes. All patients had recently received COVID-19 mRNA booster vaccine prior to...
239 Background: Previous authorities have commented on the lack of data regarding overall prevalence Skeletal-Related Events (SREs) in Castrate Resistant Prostate Cancer (CRPC) patients who not received therapy for SRE prevention. We describe a cohort 129 followed to death. Methods: treated with palliative chemotherapy CRPC at University College Hospital London between 01/01/2006 and 31/12/2010 had retrospective collection concerning date prostate cancer diagnosis, CRPC, death, bone...
e12023 Background: We are observing increasing numbers of patients with advanced breast cancer and peritoneal metastases. There few published data regarding the prognosis, clinical characteristics, management such individuals. Methods: The electronic imaging database at Charing Cross Hospital was searched for terms ’breast,’ ’cancer or tumor,’ ’peritoneal,’ ’ascites’ from 2000–2008. Those confirmed disease cancer, as described on ultrasound staging CT reports a clinico-pathologic diagnosis,...
4576 Background: Bladder Urothelial Carcinoma (BLCA) is the most common type of bladder cancer and sixth frequent in US. High numbers lymphocytes colocated with tumour-associated stromal (TAS) tissue has demonstrated prognostic significance for overall survival multiple cancers. Our goal this study was to explore an automated score quantify colocalisation TAS (OS) BLCA patients from Haematoxylin & Eosin (H&E) stained Whole Slide Images (WSIs). Methods: Two cohorts were included...
they are the victim of microaggressions: 1: never or almost to 5: very frequently.The term "microaggressions" was not defined, allowing residents determine what feel it be.Pearson product moment correlation between two variables calculated and statistical significance p<0.05 determined.Results: 20 out 27 responded questionnaire.Seven scored for at least mild depression (three severe), nine anxiety (five 11 stress (one severe).The average rating on frequency being microaggressions 2.2 (95%CI:...
residency programs should consider offering electives in the medical humanities to improve empathy, communication, observation, and decrease burnout their residents.
The authors present a case of 51-year-old female who presented to the emergency department with general malaise, headache, neck stiffness, and an expanding rash consistent Lyme neuroborreliosis. In this report, clinical presentation, diagnosis, management neuroborreliosis different presentations erythema migrans are discussed.
Event Abstract Back to Divergent prognostic significance of diagnostic biopsy stromal immune infiltrate assessment in bladder cancer treated with radical cystectomy versus radiotherapy Robert Pell1, Anne Kiltie1*, Selina Bhattarai2, Edward Ottley1 and Christiana Kartsonaki3 1 Department Oncology, Medical Sciences Division, University Oxford, United Kingdom 2 Leeds Teaching Hospitals NHS Trust, 3 Nuffield Population Health, Introduction In solid tumours, identification high percentage...