A5074000105- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- IL-33, ST2, and ILC Pathways
- Wnt/β-catenin signaling in development and cancer
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Tryptophan and brain disorders
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Adipose Tissue and Metabolism
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
Hasselt University
2020-2024
National MS Center Melsbroek
2022-2024
Significance The loss of myelin around axons is a main pathological hallmark various neurological diseases. In early disease stages, this sheath restored through process called remyelination. Later, remyelination fails and becomes the major driver progression. Despite clear demand for remyelination-enhancing therapies, need currently unmet. Here we present oncostatin M receptor signaling its downstream effector molecule tissue inhibitor metalloproteinases-1 as decisive mediators successful...
Abstract Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into central nervous system (CNS) play a crucial role in initiation of demyelination and neurodegeneration multiple sclerosis (MS). Recently, extracellular vesicles (EV) secreted by BBB endothelial cells (BBB-EC) have emerged as unique form cell-to-cell communication that contributes to cerebrovascular dysfunction. However, precise impact different size-based subpopulations BBB-EC-derived EV (BBB-EV) on early stages...
University MS Center, Campus Diepenbeek, Belgium Neuro-Immune Connections and Repair Lab, Department of Immunology Infection, Biomedical Research Institute, Hasselt University, *Correspondence to: Bieke Broux, PhD, [email protected]. This is an open-access article distributed under the terms Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, reproduction in any medium, provided original work properly cited.
Abstract Obesity is a growing pandemic that increases the risk for cardiovascular diseases, type 2 diabetes, and particularly in women also of cancer neurodegenerative disorders such as dementia multiple sclerosis. Preclinical studies on obesity focus male mice they gain bodyweight faster show clear pro-inflammatory phenotype. Here, using female mice, we induced by feeding high fat diet (HFD), compared adipose tissue (AT) inflammation at same adiposity stage (% AT/bodyweight) between both...