A5042158976- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Allergic Rhinitis and Sensitization
- Cardiac Structural Anomalies and Repair
- Robotics and Sensor-Based Localization
- Cerebrovascular and Carotid Artery Diseases
- Sexual function and dysfunction studies
- Lichen and fungal ecology
- Trypanosoma species research and implications
- Hormonal and reproductive studies
- Sexuality, Behavior, and Technology
- Extracellular vesicles in disease
- Cardiovascular Issues in Pregnancy
- Coronary Interventions and Diagnostics
- Advanced Manufacturing and Logistics Optimization
- Olfactory and Sensory Function Studies
- Pericarditis and Cardiac Tamponade
- Cancer Cells and Metastasis
- Remote Sensing and LiDAR Applications
- Streptococcal Infections and Treatments
- Machine Learning in Materials Science
- Lysosomal Storage Disorders Research
Biogem
2021-2024
University of Naples Federico II
1985-2023
Parthenope University of Naples
2019
Ito Hospital
2016
Regione Campania
1997
Institute of Genetics and Biophysics
1975
Single-cell RNA sequencing is the reference technology to characterize composition of tumor microenvironment and study heterogeneity at high resolution. Here we report Single CEll Variational ANeuploidy analysis (SCEVAN), a fast variational algorithm for deconvolution clonal substructure tumors from single-cell RNA-seq data. It uses multichannel segmentation exploiting assumption that all cells in given copy number clone share same breakpoints. Thus, smoothed expression profile every...
Penile prosthesis implantation is the solution of choice in patients who have failed or present contraindication to use all conservative treatment for erectile dysfunction (ED). Overall, satisfaction rates are high, with more than 80% and partners fully satisfied cosmetic functional result surgery. Chronic postoperative pain, penile shortening, soft hyposensitive glans, pencil like penis syndrome difficulty cycle device represent most common causes patient's dissatisfaction. Satisfaction...
Recent studies have highlighted the importance of cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its different subtypes. We investigated whether plasma cfDNA methylation, using Methylated Immunoprecipitation High-Throughput Sequencing (cfMeDIP-seq), may be informative characterizing patients with BRCA1/2 germline mutations for early detection response to therapy.
ABSTRACT Here we report Single CEll Variational ANeuploidy analysis (SCEVAN), a fast variational algorithm for the deconvolution of clonal substructure tumors from single cell data. It uses multichannel segmentation exploiting assumption that all cells in given copy number clone share same breakpoints. Thus, smoothed expression profile every individual constitutes part evidence each subclone. SCEVAN can automatically and accurately discriminate between malignant non-malignant cells,...
Abstract Cell-free DNA (cf-DNA) circulates in the blood due to cell death, which can result from normal cellular processes or specific diseases such as cancer and others. The set of epigenetic footprints cf-DNA, nucleosome organization, end-motifs distribution, fragmentation pattern, methylation signatures, constitute a key factor non-tumor-informed liquid biopsies because status is highly tissue-specific distinguish types subtypes. We developed Fragment Analysis for Tumor Evaluation with...
The LAST operation, in spite of few drawbacks, represents a good option for single Left Anterior Descending (LAD) revascularization. This procedure does not allow multivessel revascularization, where hybrid have been previous described. We report preliminary experience with the operation performed high risk patients.From October 2004 to February 2005, 11 male patients (mean age 74 +/- 8 years) underwent operation. Mean predicted death EUROSCORE and Parsonnet score were 29% 31% respectively....
Background In Barletta, a city of Puglia in southern Italy, between May and June 2009, at the ‘Dimiccoli’ Hospital, Emergency Department, 189 people out 4440 (about 4%) have been found positive to disturbances allergic type. On 25th hot day (max. temperature: 28°C) immediately after thunderstorm, 15 patients 189, rushed above mentioned Hospital. Among those patients, there was 51 years old woman who complained oculo-rhinitis, cough, chest tightness being outside on her balcony once it...
Background Asthma exacerbation associated with thunderstorms has been reported in several countries. Common to all epidemics of thunderstorm-related asthma is a significant increase atmospheric allergen load during and immediately after thunderstorm. Sensitization Alternaria species or grass parietaria pollens suggested play key role asthma. The only event Mediterranean area was attributed sensitization pollen.