A5038577140- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Natural Compounds in Disease Treatment
- Multiple Myeloma Research and Treatments
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Bone Tissue Engineering Materials
- DNA Repair Mechanisms
- Immune cells in cancer
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Inflammatory Biomarkers in Disease Prognosis
- Neuroscience and Neuropharmacology Research
- Head and Neck Anomalies
- Cancer Immunotherapy and Biomarkers
- Proteoglycans and glycosaminoglycans research
Stanford University
1998
Mesenchymal stem cells (MSCs) play a crucial role in regulating normal skeletal homeostasis and, case of injury, bone healing and reestablishment integrity. Recent scientific literature is focused on the development regeneration models where MSCs are combined with biomimetic three-dimensional scaffolds able to direct MSC osteogenesis. In this work osteogenic potential human isolated from adipose tissue (hADSCs) has been evaluated vitro combination collagen/Mg doped hydroxyapatite scaffolds....
Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor currently used for the treatment of alcoholism. Here, we show that multiple myeloma (MM) cell lines and primary cells from newly diagnosed relapsed/resistant patients affected by MM, acute myeloid lymphoblastic leukemia are significantly sensitive to DSF alone in combination with copper. These effects present at doses lower than those achievable vivo after standard administration. The cytotoxic effect achieved this comparable obtained...
The Low-Affinity Nerve Growth Factor Receptor (LNGFR), also known as CD271, is a member of the tumor necrosis factor receptor superfamily. CD271 cell surface marker defines subset multipotential mesenchymal stromal cells and may be used to isolate enrich derived from bone marrow aspirate. In this study, we compare proliferative differentiation potentials CD271+ CD271- cells. Mesenchymal were isolated aspirate adipose tissue by plastic adherence positive selection. proliferation assessed...
Traumatic injury or surgical excision of diseased bone tissue usually require the reconstruction large defects unable to heal spontaneously, especially in older individuals. This is a big challenge requiring development biomaterials mimicking structure and capable inducing right commitment cells seeded within scaffold. In particular, given their properties availability, human adipose-derived stem are considered as better candidate for autologous cell transplantation. order evaluate...
Abstract The bone grafting is the classical way to treat large defects. Among available techniques, autologous still most used but, however, it can cause complications such as infection and donor site morbidity. Alternative innovative methods rely on development of biomaterials mimicking structure properties natural bone. In this study, we characterized a cell-free scaffold, which was subcutaneously implanted in mice then analyzed both vivo ex after 1, 2, 4, 8 16 weeks, respectively. Two...
Recent studies have highlighted the importance of cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its different subtypes. We investigated whether plasma cfDNA methylation, using Methylated Immunoprecipitation High-Throughput Sequencing (cfMeDIP-seq), may be informative characterizing patients with BRCA1/2 germline mutations for early detection response to therapy.
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive types cancer characterized by complete refractoriness to multimodal treatment approaches. Therapeutic strategies based on simultaneous use proteasome inhibitors and death receptor ligands have been shown induce apoptosis in several tumor but not yet explored ATC.The aim this study was investigate ability inhibitor Bortezomib ATC cell lines. used as a single agent or combination with TNF-related apoptosis-induced ligand (TRAIL),...
Thyroid carcinoma is the most common endocrine neoplasm, with highest mortality rate of all cancers. Among malignancies, ~80% are papillary thyroid carcinomas (PTCs). In initiation and progression this tumor, genetic alterations in mitogen-associated protein kinase pathway, including RAS point mutations, RET/PTC oncogene rearrangements BRAF play an important role, particularly deciding targeted therapy. present study, a small population tumor cells, known as spheres, were isolated...
Oral squamous cell carcinoma (OSCC) is a commonly occurring head and neck cancer it characterized by high metastasis grade. The aim of this study was to evaluate for the first time effect BAY-117082, selective NLRP3 inflammasome inhibitor, in an vivo orthotopic model OSCC its role invasiveness processes neighbor organs such as lymph node, lung, spleen tissues. Our results demonstrated that BAY-117082 treatment, at doses 2.5 mg/kg 5 mg/kg, able significantly reduce presence microscopic tumor...
Background: Prostate cancer is the second most common in males worldwide, and its incidence rising. Early detection crucial for improving outcomes, but current screening methods have limitations. While prostate-specific antigen (PSA) testing widely used tool, it has poor specificity, leading to a high rate of false positives unnecessary biopsies. The existing biopsy techniques are invasive associated with complications. liquid that analyze biomarkers blood or other bodily fluids offer...
Acute myeloid leukemia (AML) is a malignant disease characterized by abnormal proliferation of clonal precursor cells. Although different strategies have been adopted to obtain complete remission, the actually progresses in about 60–70% patients. Bortezomib has used multiple myeloma and other lymphoid malignancies because its antitumor activity. Here we examined sensitivity bone marrow cells from AML patients (34 patients: 25 newly diagnosed, 4 relapsed, 5 refractory) bortezomib alone or...
Human adipose-derived stem cells are an abundant population of readily isolated from human adipose tissue that can differentiate into connective lineages including bone, cartilage, fat, and muscle. Activating transcription factor 5 is a the ATF/cAMP response element-binding protein (CREB) family. It transcribed in two types mRNAs (activating isoform 1 activating 2), encoding same single 30-kDa protein. Although it well demonstrated regulates proliferation, differentiation, apoptosis, little...
Neo-adjuvant radiotherapy is frequently employed in the therapeutic management of locally advanced rectal cancer (LARC). Radiotherapy can both reduce local recurrence and improve success surgical procedures by reducing tumor mass size. However, some patients show a poor response to treatment, which results primary resistance or relapse after apparent curative surgery. In this work, we report vitro vivo models based on patient-derived stem cells (CSCs); these are able predict individual...
Despite a large amount of data, the optimal surgical management differentiated thyroid cancer remains controversial. Current guidelines recommend total thyroidectomy if primary is >4 cm, while for tumors that are between 1 and 4 cm in size, either bilateral or unilateral may be appropriate as treatment. In general, would seem to preferable because subtotal resection can correlated with higher risk local recurrences cervical lymph node metastases; on other hand, associated more...
Cisplatin is one of the chemotherapeutic drugs used for management oral carcinoma, in which combined therapies are estimated to exert superior therapeutic efficacy compared with monotherapy. It known that poly(ADP-ribosyl)ation implicated a multiplicity cellular activities, such as DNA repair and cell death. Based on these, PARP inhibitors treatment cancers; however, capacity associated anti-cancer have not been completely assessed carcinoma. Here, we evaluated effects PARPi veliparib...
Radiotherapy represents a first-line treatment for many inoperable lung tumors. New technologies offer novel opportunities the of cancer with administration higher doses radiation in smaller volumes. Because both therapeutic and toxic effects are dose-dependent, it is important to identify minimal dose protocol each individual patient that maintains efficacy while decreasing toxicity. Cancer stem cells sustain tumor growth, promote metastatic dissemination, may give rise secondary...
Oral squamous cell-carcinoma (OSCC) is a common cancer which arises from the alveolar ridge, buccal mucosa, and tongue. Among OSCC, incidence of tongue (TSCC) growing all over world. carcinogenesis has been linked to genetic mutations, chromosomal aberrations viral factors. Apoptosis angiogenesis play key role in development oral cancer. Therefore, it very important discover new therapeutic strategies counteract progression. This study aimed investigate effect KYP-2047 an vitro model TSCC...
Background and purpose: Lung cancer is the leading cause of death in both men women, constituting a major public health problem worldwide. Non-small-cell lung accounts for 85%-90% all cancers. We propose compound that successfully fights tumor growth vivo by targeting enzyme GARS1. Experimental approach: present an in-depth investigation mechanism through which Fraisinib [meso-(p-acetamidophenyl)-calix(4)pyrrole] affects human adenocarcinoma A549 cell line. In xenografted model...