A5060847523- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Chemotherapy-related skin toxicity
- Cancer-related Molecular Pathways
- Osteoarthritis Treatment and Mechanisms
- Kruppel-like factors research
- Knee injuries and reconstruction techniques
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Hormonal Regulation and Hypertension
- Pain Mechanisms and Treatments
- Nonmelanoma Skin Cancer Studies
- Ferroptosis and cancer prognosis
- Adrenal and Paraganglionic Tumors
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
Policlinico Universitario di Catania
2006
The management of chondral defects represents a big challenge because the limited self-healing capacity cartilage. Many approaches in this field obtained partial satisfactory results. Cartilage tissue engineering, combining innovative scaffolds and stem cells from different sources, emerges as promising strategy for cartilage regeneration. aim study was to evaluate capability cell-free collagen I-based scaffold promote cartilaginous repair after orthotopic implantation vivo. Articular...
Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics, such as oxaliplatin (L-OHP). The aim the present work was to evaluate potential beneficial effects 2-pentadecyl-2-oxazoline (PEA-OXA) in murine model oxaliplatin-induced peripheral (OIPN). OIPN induced by an intraperitoneally injection L-OHP rats on five consecutive days (D0–4) for final cumulative dose 10 mg/kg. PEA-OXA and ultramicronized palmitoylethanolamide (PEAum), both mg/kg, were...
Metastatic disease is the major cause of cancer-related deaths. Increasing evidence shows that primary tumor cells can promote metastasis by preparing local microenvironment distant organs, inducing formation so-called "pre-metastatic niche". In recent years, several studies have highlighted among tumor-derived molecular components active in pre-metastatic niche formation, small extracellular vesicles (sEVs) play a crucial role. Regarding liver metastasis, ability sEVs to affect activities...
Neo-adjuvant radiotherapy is frequently employed in the therapeutic management of locally advanced rectal cancer (LARC). Radiotherapy can both reduce local recurrence and improve success surgical procedures by reducing tumor mass size. However, some patients show a poor response to treatment, which results primary resistance or relapse after apparent curative surgery. In this work, we report vitro vivo models based on patient-derived stem cells (CSCs); these are able predict individual...
Despite a large amount of data, the optimal surgical management differentiated thyroid cancer remains controversial. Current guidelines recommend total thyroidectomy if primary is >4 cm, while for tumors that are between 1 and 4 cm in size, either bilateral or unilateral may be appropriate as treatment. In general, would seem to preferable because subtotal resection can correlated with higher risk local recurrences cervical lymph node metastases; on other hand, associated more...
Radiotherapy represents a first-line treatment for many inoperable lung tumors. New technologies offer novel opportunities the of cancer with administration higher doses radiation in smaller volumes. Because both therapeutic and toxic effects are dose-dependent, it is important to identify minimal dose protocol each individual patient that maintains efficacy while decreasing toxicity. Cancer stem cells sustain tumor growth, promote metastatic dissemination, may give rise secondary...
Prolyl 3-hydroxylase 2 (P3H2) catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly type IV. Its activity has never been directly associated to angiogenesis. Here, we identified P3H2 gene through a deep-sequencing transcriptome analysis human umbilical vein endothelial cells (HUVECs) stimulated with vascular growth factor A (VEGF-A). Differently from many previous studies carried out stimulation not starved HUVECs, but grown maintain best condition for their in...
Background and purpose: Lung cancer is the leading cause of death in both men women, constituting a major public health problem worldwide. Non-small-cell lung accounts for 85%-90% all cancers. We propose compound that successfully fights tumor growth vivo by targeting enzyme GARS1. Experimental approach: present an in-depth investigation mechanism through which Fraisinib [meso-(p-acetamidophenyl)-calix(4)pyrrole] affects human adenocarcinoma A549 cell line. In xenografted model...
Paraganglioma is a rare neoplasia of neural crest origin. It most commonly arises in carotid body, jugular bulb, tympanic plexus on the promontory, and along vagal nerve pathway or anywhere paraganglia pathway. This review describes our experience cervical paraganglioma. Although there no consensus literature preoperative angiographic embolization, we think angiography gold standard diagnosis treatment A small paraganglioma probably does not usually require embolization because risks may...
Pazopanib is a multitarget tyrosine kinase inhibitor used in the treatment of renal cancer and soft tissue sarcoma. Its use commonly associated with number side effects, such as hemorrhagic diathesis, neutropenia, leukopenia, thrombocytopenia, nausea, vomiting, abdominal pain, increased serum aspartate aminotransferase, alanine decreased glucose, bilirubin, phosphate magnesium, fatigue, hypertension, diarrhea, anorexia, proteinuria, hypothyroidism. Abscesses metastases caused by pazopanib...
Background: Differentiated thyroid carcinoma (DTC) is the most common malignant tumor of gland and causes local and/or distant metastases. form, representing more than 90% all cancers derives from follicular cells thyroid. Choroidal metastasis DTC extremely rare. Only a few cases have been reported in literature.
Aims: Evaluate safety and efficacy of nab-paclitaxel in pre-treated metastatic breast cancer (MBC) patients a real-life setting.
Abstract Background : The liver is the main metastatic site for patients with colorectal cancer (CRC) and represents most frequent cause of death affected by this cancer. In recent years, a number studies have highlighted crucial role played small extracellular vesicles (sEVs) released cells in initiating pre-metastatic niche formation liver, specifically affecting activities non-parenchymal as Kupffer hepatic stellate cells, while hepatocytes still remains unknown. Even if cell component...