A5022813412- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- interferon and immune responses
- Aluminum toxicity and tolerance in plants and animals
- Data-Driven Disease Surveillance
- Reproductive Physiology in Livestock
- Effects of Environmental Stressors on Livestock
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Virology and Viral Diseases
- Toxin Mechanisms and Immunotoxins
- Curcumin's Biomedical Applications
- Meat and Animal Product Quality
- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
- Prion Diseases and Protein Misfolding
- Rabbits: Nutrition, Reproduction, Health
Universidad Publica de Navarra
2025
Agrobiotechnology Institute
2018-2024
Gobierno de Navarra
2018-2021
Small ruminant lentiviruses (SRLV) cause multisystemic chronic inflammatory disease and significant economic losses in sheep goats worldwide. However, no vaccines or therapies are currently available. In this study, a recombinant Sendai virus (SeV) vector encoding the SRLV gag-P25 gene (rSeV-GFP-P25) from EV1 strain was generated using In-FUSION cloning rescued SeV reverse genetic system. Transgene expression stimulation of innate immunity interferon-stimulated genes (ovine A3Z1, OBST2...
Small ruminant lentiviruses (SRLVs) are endemic in most areas of Europe, causing a chronic infection and multisystemic disease affecting the udder, carpal joints, lungs, central nervous system. Due to lack treatments protective vaccination strategies, control is focused on identification infected animals through serological or molecular techniques. However, antigenic genetic heterogeneity SRLVs represent clear drawback for diagnosis. Infected may present lower animal production parameters...
Small ruminant lentiviruses (SRLV) cause an incurable multiorganic disease widely spread in sheep and goats that disturbs animal welfare production. In the absence of a vaccine, control measures have been traditionally based on early diagnosis breeding with virus-inactivated colostrum segregation seropositive animals. However, antigenic heterogeneity, poor antibody production due to low viral load, single strain design most available ELISA, pose threat SRLV diagnosis. Genome-wide association...
Orf is a highly contagious eruptive viral disease of the skin and mucosa sheep goats. Although vaccination with live or attenuated orf virus preferred option for control, vaccine unavailable in many countries. Treatment lesions involves standard hygiene numerous cases, management presumptive secondary infections antibiotics, increasing risks antimicrobial resistance (AMR). The wound dressing formulation Tri-Solfen
Granulomas are inflammation-derived structures elicited by foreign bodies or certain infections. Aluminum adjuvants included in vaccines induce granulomas many species. In sheep, these persistent and consist of activated macrophages. Small ruminant lentiviruses (SRLV), which macrophage-tropic lentiviruses, cause a chronic wasting disease affecting animal welfare production. Here, we studied the occurrence SRLV postvaccination retrieved from naturally infected ewes after vaccination...
Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome sheep—the so-called ovine autoimmune-inflammatory induced by adjuvants (ASIA syndrome). This work aimed characterize the effects of repetitive injection Al-hydroxide containing products lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups seven lambs (Vaccine,...
Small ruminant lentiviruses (SRLVs) are widely spread in the ovine and caprine populations, causing an incurable disease affecting animal health production. Vaccine development is hindered owing to high genetic heterogeneity of selection T-cell antibody escape mutants, requiring antigen delivery optimization. Sendai virus (SeV) a respiratory paramyxovirus mice that has been recognized as potent inducer innate immune responses several species, including mouse human. The aim this study was...
Abstract Orf virus (ORFV) is the etiological agent of Contagious Ecthyma (CE), a worldwide disease that mainly affects sheep, goats, wild ruminants, and humans. Here, we determined complete genome sequence two ORFV strains from Spain (NAV ARA) Argentina (HRE CHB), representing second report Europe first South America. The assembled genomes ARA, CHB, HRE, NAV were found to be 137,891 bp, 137,160 137,340 137,214 bp long, respectively, containing 132 genes in each strain, showing high amino...