A5081013272- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Oral microbiology and periodontitis research
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Biochemical Analysis and Sensing Techniques
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Child Nutrition and Feeding Issues
- Orthodontics and Dentofacial Orthopedics
- Streptococcal Infections and Treatments
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Influenza Virus Research Studies
- Advanced Glycation End Products research
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Clinical Nutrition and Gastroenterology
- Inflammatory mediators and NSAID effects
- HIV/AIDS oral health manifestations
Leipzig University
2021-2024
Medical University of Vienna
2018-2023
Center for Rheumatology
2022
University Hospital Leipzig
2020-2021
Klinik und Poliklinik für Neurologie
2020-2021
Tianjin Stomatological Hospital
2020
University Clinic of Traumatology
2020
Research Institute of Dallas
2020
Baylor Medical Center at Garland
2020
University of Rochester Medical Center
2019
Abstract Objectives Successful vaccination is key to overcoming the COVID-19 pandemic. Immunosuppressive medication known potentially compromise responses, and expansion of our knowledge on efficacy in patients with autoimmune inflammatory rheumatic diseases (AIIRD) therefore utmost importance. Methods We conducted a single-centre observational study evaluated approved vaccines 303 adult AIIRD patients. Serum levels IgG antibodies against S1 subunit SARS-CoV-2 spike proteins (anti-S IgG)...
Memory B cells (MBCs) are key determinants of the cell response to influenza virus infection and vaccination, but effect different forms antigen exposure on MBC populations has received little attention. We analyzed peripheral blood mononuclear plasma collected following human H3N2 investigate relationship between hemagglutinin-specific antibody production changes in size character hemagglutinin-reactive populations. Infection produced increased concentrations IgG reactive H3 head infecting...
Background/Objectives Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides ( LPS ) at low concentrations. The aim this study was to investigate, whether pretreatment Porphyromonas gingivalis leads endotoxin induction and possible alterations in toll‐like receptor TLR 2‐ 4‐induced response human periodontal ligament cells hPDLC s). Material Methods Primary s were pretreated P. (0.1 or 0.3 μg/ mL for 24 hours...
Tannerella forsythia and Porphyromonas gingivalis target distinct virulence factors bearing a structurally conserved C-terminal domain (CTD) to the type IX protein secretion system (T9SS). The T9SS comprises an outer membrane translocation complex which works in concert with signal peptidase for CTD cleavage. Among prominent cargo linked periodontal diseases are TfsA TfsB components of T. forsythia's cell surface (S-) layer, bacterium's BspA antigen set cysteine proteinases (gingipains) from...
The endocannabinoid system is involved in the regulation of periodontal tissue homeostasis. Synthetic cannabinoid methanandamide (Meth-AEA) has improved stability and affinity to receptors compared its endogenous analog anandamide. In present study, we investigated effect on production pro-inflammatory mediators primary human ligament cells (hPdLCs).hPdLCs were treated with Meth-AEA for 24 h, resulting interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1 was measured absence or...
CD4+CD8+ double-positive (DP) T cells are expanded in the peripheral blood of a subset patients with RA. This study examines clinical significance DP RA.In 70 RA patients, were measured by flow cytometry. Clinical data obtained, and hand feet radiographs scored according to Sharp/van der Heijde (SvdH) method. The association between cell frequency erosive joint destruction was analysed correlation multiple logistic regression analysis.Nineteen (27.1%) displayed increased frequencies, which...
Objective CD4 + CD8 T cells are increased in patients with rheumatoid arthritis (RA). They not only associated joint erosions established disease but also present the preclinical stages of RA. This study aims to further investigate their expansion context cell clonality RA, as well responsiveness cell–targeted treatment. Methods Single‐cell RNA (scRNA) and single‐cell receptor (TCR) sequencing data were used determine coreceptor expression TCR sequences assess RA (n = 3) healthy controls 2)....
CARDIOVASCULAR RISK PROFILE OF PATIENTS WITH INFLAMMATORY ARTHRITIS: Patients with inflammatory arthritis have an increased risk of cardiovascular disease compared to the general population. The discovery this fact dates back over a decade ago, but morbidity and mortality in these patients not yet significantly improved. In 2021, management remains important aspect for practitioners, rheumatologists researchers. ASSESSMENT: Risk scores used population often underestimate arthritis....
Abstract Women with triple-negative breast cancer (TNBC) have an increased pathologic complete response rate (pCR; residual disease after neoadjuvant chemotherapy) as compared to women non-TNBC, and those pCR a 90% disease-free survival. However, TNBC who do not achieve risk of recurrence, decreased overall survival, post-recurrence survival non-TNBC pCR. A high priority for clinical research is therefore increase the in axilla preoperative therapy, therapeutic options patients are limited....
<h3>Background</h3> CD4CD8 double-positive (DP) T cells are expanded in rheumatoid arthritis (RA) and associated with erosive disease [1]. The majority of DP the periphery have an effector phenotype were reported to originate from either CD4 or CD8 single-positive (SP) [2]. origin express a CD8αα homodimer, corresponding CD4+CD8<sup>low</sup> fluorescence pattern flow cytometry, while CD8αβ heterodimer, which results CD4+CD8<sup>high</sup> pattern. Reports on presence polyfunctional RA...
The transient worsening of oral health sometimes accompanies orthodontic treatment (OT), and the extent this effect might depend on whether patients are treated with traditional brackets or clear aligners. Saliva is an important tool for monitoring influences functional properties various cells. This study aimed to compare effects saliva from undergoing OT Invisalign aligners human gingival fibroblasts epithelial cells in vitro. Unstimulated was collected 15 16 before 3 6 months after...
Abstract Background Endocannabinoid system is involved in the regulation of periodontal tissue homeostasis. Synthetic cannabinoid methanandamide (Meth-AEA) has an improved stability and affinity to receptors compared its endogenous analogue anandamide. In present study, we investigated effect on production pro-inflammatory mediators primary human ligament cells (hPdLCs). Methods hPdLCs were treated with Meth-AEA for 24 h resulting interleukin (IL)-6, IL-8, monocyte chemotactic protein...
Abstract Background: The endocannabinoid system is involved in the regulation of periodontal tissue homeostasis. Synthetic cannabinoid methanandamide (Meth-AEA) has improved stability and affinity to receptors compared its endogenous analog anandamide. In present study, we investigated effect on production pro-inflammatory mediators primary human ligament cells (hPdLCs). Methods: hPdLCs were treated with Meth-AEA for 24 h, resulting interleukin (IL)-6, IL-8, monocyte chemotactic protein...
Background: CD4 + /CD8 double-positive T (dpT) cells are a set of pathologic cells, representing about 1% peripheral blood and increasing with age in healthy individuals. Patients rheumatoid arthritis (RA) more frequently have expanded dpT compared to age-matched controls, up frequency 8% [1]. However, whether cell expansion harbors clinical significance RA is not known. Objectives: The goal the study was assess possible associations DPT features patients RA. Methods: In this cross-sectional...