A5056680477- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Air Quality and Health Impacts
- Cardiac Health and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Eating Disorders and Behaviors
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Energy and Environment Impacts
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Nutritional Studies and Diet
- Cognitive Abilities and Testing
University of California, San Diego
2019-2023
Virginia Commonwealth University
2021
Abstract Introduction The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). LC is implicated regulating the sleep–wake cycle, modulating cognitive function, and AD progression. Methods Participants were 481 men (ages 62 to 71.7) from Vietnam Era Twin Study of Aging. structural integrity was indexed by neuromelanin‐sensitive magnetic resonance imaging (MRI) contrast‐to‐noise ratio (LC CNR ). We examined , cognition, amnestic mild impairment (aMCI),...
Fine particulate matter (PM2.5) and nitrogen dioxide (NO2) measures of ambient air pollution are associated with accelerated age-related cognitive impairment, Alzheimer's disease related dementias (ADRD).
Clarifying the relationship between depression symptoms and cardiometabolic related health could clarify risk factors treatment targets. The objective of this study was to assess whether in midlife are associated with subsequent onset problems.
Neuroimaging signatures based on composite scores of cortical thickness and hippocampal volume predict progression from mild cognitive impairment to Alzheimer's disease. However, little is known about the ability these among cognitively normal adults impairment. Towards that end, a signature sensitive microstructural changes may predate macrostructural atrophy should be useful. We hypothesized that: (i) validated MRI-derived disease in middle-aged would impairment; (ii) novel grey matter...
Abstract Background and aims Smoking is associated with increased risk for brain aging/atrophy dementia. Few studies have examined early associations aging. This study aimed to measure whether adult men a history of heavier smoking in mid‐life would older than predicted age 16–28 years later. Design Prospective cohort observational study, utilizing pack data from average 40 (early mid‐life) predicting difference scores (PBAD) at ages 56, 62 (later 68 old age). Early alcohol use was also...
Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such Alzheimer's Disease. Despite their increasing application, the genetic environmental etiology of global PBA indices is unknown. Likewise, degree which influences longitudinally stable how changes over time also We analyzed from 734 men Vietnam Era Twin Study Aging with repeated MRI assessments between ages 51-72 years. Biometrical analyses...
ABSTRACT Pathological changes in Alzheimer’s disease (AD) begin decades before dementia onset. Because locus coeruleus tau pathology is the earliest occurring AD pathology, targeting indicators of (dys)function may improve midlife screening for earlier identification risk. Pupillary responses during cognitive tasks are driven by and index effort. Several findings suggest task-associated pupillary response as an early marker Requiring greater effort suggests being closer to one’s compensatory...
Despite their increasing application, the genetic and environmental etiology of global predicted brain ageing (PBA) indices is unknown. Likewise, degree to which influences in PBA are longitudinally stable how changes over time also We analyzed data from 734 men Vietnam Era Twin Study Aging with repeated MRI assessments between ages 52 72 years. Biometrical analyses revealed significant highly correlated estimates additive heritability ranging 59% 75%. Multivariate longitudinal modelling...
Little is known about the genetics of hippocampal volume change during later life. The degree to which genetic risk for Alzheimer’s disease (AD) contributes prior AD onset also unclear. We estimated heritability change, as well contribution APOE genotype and polygenic risk. Data were obtained from Vietnam Era Twin Study Aging. A latent model was used characterize baseline across two waves. Average ages at each wave were61.9 years (SD=2.6) 67.5 (SD=2.6), average interval 5.6 (SD=0.5)....
ABSTRACT Importance Both cognitive reserve and modifiable lifestyle behaviors are associated with dementia risk. The effect of early on late midlife brain aging could inform identification risk reduction future dementia. Objective Determine associations young adult reserve, behaviors, the reserve-by-lifestyle interaction age. Examine relationship between mild impairment (MCI) Design Participants were from nationally representative Vietnam Era Twin Study Aging (VETSA). Cognitive was assessed...
Abstract Exposure to harmful substances and chemicals such as tobacco smoke, (e.g., herbicides, pesticides, Agent Orange) metal dust has been associated with increased risk of developing cancer, cardiovascular disease, other diseases that contribute shorter life expectancy. Associations brain health in relation these exposures are less well studied. We examined the relationship between prolonged exposure different 498 male participants average age 68 (range 61 73) from Vietnam Era Twin Study...