A5101765426- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Circular RNAs in diseases
- Acute Lymphoblastic Leukemia research
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Zunyi Medical University
2004-2023
Affiliated Hospital of Zunyi Medical College
2021
University Health Network
2013-2020
Princess Margaret Cancer Centre
2010-2020
Ontario Institute for Cancer Research
2010-2011
Cancer Institute (WIA)
2010
BACKGROUND: Dilated cardiomyopathy is characterized by left ventricular dilation and continuous systolic dysfunction. Mitochondrial impairment critical in dilated cardiomyopathy; however, the underlying mechanisms remain unclear. Here, we explored cardioprotective role of a heart-enriched long noncoding RNA, repressive transcript (DCRT), maintaining mitochondrial function. METHODS: The DCRT knockout (DCRT −/− ) mice cells were developed using CRISPR-Cas9 technology. Cardiac-specific...
The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational NEDD8 conjugation onto target proteins. MLN4924, a selective NAE inhibitor, has displayed preclinical anti-tumor activity in vitro and vivo, promising clinical been reported patients with refractory hematologic malignancies. Here, we sought to understand mechanisms resistance MLN4924. K562 U937 leukemia cells were exposed over 6 month period MLN4924 populations resistant (R-K562MLN, R-U937MLN)...
Abstract Purpose Oncostatin M (OSM) is involved in the regulation of osteogenic differentiation and has a major role development heterotopic ossification. The OSM tendon-derived stem cells (TDSCs) its mechanism have not been reported. This study aim to investigate TDSCs mechanism. Methods were differentiated medium for 7 days. Recombinant was added 14 effect Janus kinase 2 (JAK2) inhibitor AZD1480 signal transducer activator transcription 3 (STAT3) stattic presence recombinant on examined...
MLN4924 is a selective inhibitor of the NEDD8-activating enzyme (NAE) and has advanced into clinical trials for treatment both solid hematological malignancies. In contrast, structurally similar compound 1 (developed by Millennium: The Takeda Oncology Company) pan E1 enzymes NAE, ubiquitin activating (UAE), SUMO-activating (SAE) currently viewed as unsuitable use given its broad spectrum inhibition. Here, we sought to understand determinants NAE selectivity. A series analogues were...
Indolent T-lymphoblastic proliferation (iT-LBP) consists of a non-neoplastic TdT + T cells in extrathymic tissues, requiring no treatment. However, due to overlapping clinical and histologic features, distinguishing iT-LBP from T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) can be challenging. Recently, flow cytometry-based evaluation TRBC1 has been used detect clonality TCRαβ mature lymphomas aid the differential diagnosis between T-ALL normal thymocytes. We present...
Abstract Background Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported. Herein, this study analyzed clinical significance potential mechanisms LUAD via bioinformatic tools. Results We found that level increased, correlated sex, age, smoking history, neoplasm staging, histological subtype TP53 mutation status patients. Kaplan-Meier survival...
Abstract Background : Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported. Herein, this study analyzed clinical significance potential mechanisms LUAD via bioinformatics tools. Results We found that level increased, correlated sex, age, smoking history, neoplasm staging, histological subtype TP53 mutation status patients. Kaplan-Meier survival...
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by the accumulation of malignant cells that have arrested maturation. Most therapeutic regimens approved or under development are cytotoxics. An alternate, but less explored approach, to induce terminal differentiation AML cells. Upon differentiation, cease proliferate die.Phosphatidylserine decarboxylase (PISD) mitochondrial enzyme converts phosphatidylserine (PS) phosphatidylethanolamine (PE). Here, we effects...
Abstract Background: Faced with the current poor prognosis of non-small cell lung cancer, this topic attempts to find new potential prognostic biomarkers improve situation.Materials and Methods: To form synthetic matrix, we searched GTEX The Cancer Genome Atlas for NSCLC transcriptomic data.The necroptosis-related factor LncRNAs were identified by co-expression analysis univariate COX regression analysis, LncRNA model was constructed using least absolute contraction selection operator...