A5103018426- Cystic Fibrosis Research Advances
- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- RNA regulation and disease
- Urticaria and Related Conditions
- Pharmaceutical Economics and Policy
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Dermatological and COVID-19 studies
- Pancreatic function and diabetes
- Lung Cancer Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Wnt/β-catenin signaling in development and cancer
- Histiocytic Disorders and Treatments
- Personal Information Management and User Behavior
- Acne and Rosacea Treatments and Effects
- Diabetes and associated disorders
- Anesthesia and Sedative Agents
University Hospitals of Leicester NHS Trust
2018-2025
University of Leicester
2019-2025
Emory University Hospital
2025
Hasbro Children's Hospital
2024
Brown University
2024
Rhode Island Hospital
2024
Lifespan
2024
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
Children's Hospital of Philadelphia
2017-2019
Sensitisation to thermotolerant fungi such as Aspergillus fumigatus and Candida albicans which can colonise the airways is associated with poor lung function in children asthma. Dysbiosis of bacteria airway microbiome has been reported between health asthma but yet be characterised for fungal sensitised asthmatic children. We investigated if microbial diversity altered school-age Sputum samples from who were (n=22) non-fungal (n=17) along without (n=15), aged 5-16 years profiled by...
The incidence of thyroid disease in children with alopecia areata (AA) has been widely studied no consensus on whether a true association AA exists. In addition, screening practices for dysfunction vary among clinicians.To reduce health care costs, eliminate unnecessary testing, and standardize clinical practices, we sought to characterize function establish guidelines screening.A single-site retrospective medical chart review was carried out an outpatient pediatric dermatology clinic...
Rhinoviruses have persisted throughout the COVID-19 pandemic, despite other seasonal respiratory viruses (influenza, parainfluenza, syncytial virus, adenoviruses, human metapneumovirus) being mostly suppressed by pandemic restrictions, such as masking and forms of social distancing, especially during national lockdown periods. Rhinoviruses, nonenveloped viruses, are known to transmit effectively via airborne fomite route, which has allowed infection among children adults continue...
Abstract Specific clinical features of aplasia cutis congenita may indicate the presence underlying cranial or cerebrovascular defects, allowing for early recognition and intervention. Most information about exists as individual case reports, with few large‐scale studies. We conducted a 7‐year retrospective chart review 90 cases identified characteristics including morphology, number lesions, anatomic location, hair collar sign, associated cutaneous features, histology, imaging results. The...
Abstract There is emerging evidence for the role of posaconazole in management Aspergillus-related cystic fibrosis (CF) lung disease. The tolerability and efficacy paediatric CF not well established. We report a prospective study over fifty-three month period evaluating safety, tolerability, pediatric CF. Fourteen children (seven males, median age 13 years, range 3–17 years) received total twenty-three courses (13 oral suspension 10 tablet formulation). Of these patient episodes, nine or...
Objectives To inform development of a preintubation checklist for pediatric emergency departments via multicenter usability testing prototype checklist. Methods This was prospective, mixed methods study across 7 sites in the National Emergency Airway Registry Pediatric Medicine (NEAR4PEM) collaborative. medicine attending physicians and senior fellows at each site were first oriented to prototype, including content previously identified using modified Delphi approach. Each used 2 simulated...
<h3>Background</h3> Although PD-(L)1 inhibitors demonstrated survival benefits vs chemotherapy in PD–(L)1–high NSCLC, <50% of patients will respond to monotherapy. Combined TIGIT/PD-(L)1 blockade prolonged progression-free (PFS) a phase 2 trial for metastatic, NSCLC. ARC-10 (phase 2, randomized, open–label [NCT04736173]) evaluated the efficacy and safety combination domvanalimab (D; Fc–silent anti–TIGIT antibody) zimberelimab (Z; anti–PD-1 Z monotherapy front-line stage IIIB–IV...
The physiologic changes in lipids during puberty type 1 diabetes (T1D) are unclear because subjects previous studies were not stratified by partial clinical remission status.To determine the effect of on lipid youth with T1D.A retrospective cross-sectional study 194 consisting 71 control age 12.9 ± 1.3 years and 123 T1D into remitters (n = 44; age, 13.0 0.8 years) nonremitters 79; 11.2 0.6 years). Partial was defined as insulin-dose adjusted HbA1c ≤9. Pubertal status determined Tanner...
Abstract Aim Non‐tuberculous mycobacteria (NTM) have emerged as an important pathogen in cystic fibrosis (CF). Early detection and treatment of NTM can preserve lung function maintain good health. Many children with CF are not regular sputum producers cough swabs cannot routinely be used to diagnose NTM. We aimed test the hypothesis that performing induction at routine annual review results earlier identification non‐sputum producing CF. Method conducted a 5‐year prospective observational...
2574 Background: OX40 is an immune costimulatory receptor, expressed on activated CD4 + and CD8 T cells, which promotes cell proliferation survival in the tumor microenvironment. BGB-A445 a novel monoclonal antibody (mAb) agonist that does not compete with endogenous ligand binding. has demonstrated antitumor activity as single agent combination anti-PD-1 mAb preclinical studies. Here, we report data from ongoing dose-escalation part of multicenter, phase 1 dose escalation/expansion study...
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Abstract Acne is one of the most common skin conditions seen by dermatologists. As with many other cutaneous diseases, due to its visibility, acne often produces a large psychosocial impact on patients who suffer from disease. Such burdens are exacerbated variation in presentation that can lead usage multiple different treatments before visible improvements appreciated. Although scales have been established determine severity clinician standpoint, patient‐oriented lacking. Clinicians use...
Serial blood, muscle, and bone concentrations of cephalothin following intravenous infusion were determined in forty-eight patients during total hip replacement. Thirty received hypotensive anesthesia the remaining eighteen without induced hypotension. The first (early) second (late) hours operation. Late serum levels lower who had In all at least one specimen contained measurable amounts cephalothin. When pentolinium (Ansolysen) was used to induce hypotension, late early lower, while use...
The relationship between fungal culture (FC) positivity and airway inflammation in CF is largely unknown. Identifying the clinical significance of filamentous fungi using both parameters biomarkers may change our antimicrobial therapeutic strategies.To investigate characteristics biomarker profile relation to detection respiratory samples obtained from patients.A prospective cohort study over 24 months, including children adults with CF. Participants provided sputum and/or bronchoalveolar...