A5041001788- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Child and Adolescent Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Airway Management and Intubation Techniques
- Bacterial biofilms and quorum sensing
- Asthma and respiratory diseases
- Emergency and Acute Care Studies
- Congenital Heart Disease Studies
- Hospital Admissions and Outcomes
- Neonatal and Maternal Infections
- Patient Safety and Medication Errors
- Global Maternal and Child Health
- Bartonella species infections research
- Otitis Media and Relapsing Polychondritis
- Machine Learning in Healthcare
- Pharmaceutical studies and practices
- Wireless Body Area Networks
University Hospitals of Leicester NHS Trust
2015-2024
University of Leicester
2018-2024
University Hospitals Coventry and Warwickshire NHS Trust
2023
Birmingham and Midland Eye Centre
2023
Leicester General Hospital
2021
University Hospitals Sussex NHS Foundation Trust
2021
Leicester Royal Infirmary
2016-2018
Peterborough City Hospital
2018
NIHR Leicester Biomedical Research Centre
2018
Bangalore Medical College and Research Institute
2013
This study aims to investigate the determinants of progression Chronic Kidney Disease (CKD) and role antioxidant supplementation in managing oxidative stress kidney function. The research used a cross-sectional with 120 participants, considering variables such as age, gender, smoking, family history, diet, alcohol consumption, education, occupation. Key findings from analysis were that age was significant contributing factor CKD progression, older individuals having greater likelihood...
Initial randomised controlled trials (RCTs) showed that prophylactic azithromycin in pregnant women improved maternal and neonatal outcomes; however, the recent evidence did not show any benefit to survival. There is conflicting over role of prophylaxis antenatal intrapartum periods. We explored whether improves outcomes.
Background Exercise capacity is an independent predictor of clinical worsening in cystic fibrosis (CF). There limited evidence the impact transmembrane conductance regulator (CFTR) modulators on exercise children with CF. The aim present study was to assess CFTR a cohort adolescents Methods A prospective single-centre carried out. Cardiopulmonary testing (CPET) performed at baseline, prior starting Symkevi or Kaftrio and between 4 8 months after treatment. Results 19 CF had CPET modulator...
Abstract Aim Non‐tuberculous mycobacteria (NTM) have emerged as an important pathogen in cystic fibrosis (CF). Early detection and treatment of NTM can preserve lung function maintain good health. Many children with CF are not regular sputum producers cough swabs cannot routinely be used to diagnose NTM. We aimed test the hypothesis that performing induction at routine annual review results earlier identification non‐sputum producing CF. Method conducted a 5‐year prospective observational...
Background: Invasive group A streptococcal disease (iGAS) can have varied clinical presentations in children, are responsible for prolonged hospital stays and cause mortality long-term morbidity children. Over the last decade, there has been an increase incidence of iGAS infections UK worldwide. This renewed focus on early diagnosis, management prevention this disease. Aim Objective: The aim study was to review children with infections. Methods: We reviewed data admitted our tertiary...
Doppler echocardiography has been demonstrated to be accurate in diagnosing valvular lesions rheumatic heart disease (RHD) when compared clinical evaluation alone.To perform children clinically diagnosed by the Jones criteria have acute fever (ARF), and then compare effectiveness of echo detecting single/multi-valvular with that initial evaluation.We enrolled 93 who were previously ARF examination. Presence enlisted, first auscultation, performing echocardiography. We found was a sensitive...
This quality improvement project helped streamline the process of newborn and infant physical examinations on maternity inpatient ward improved patient journey workforce satisfaction.
Background Children and young people (CYP) with asthma in the UK are at higher risk of poor outcomes compared other high-income European countries due to factors including access high-quality reviews, diagnostic testing inconsistent postattack reviews. The Leicester Integrated Care Board funded first pilot hub for CYP, investigate feasibility effectiveness hubs, providing reviews along education, opportunity carry out lung function tests optimise treatment. Methods Clinical study CYP aged...
This study investigates the transformative effects of digitalization on postal saving schemes in aftermath demonetization. Analyzing Likert-scale responses from 230 users, research identifies nuanced user perceptions across five key aspects: user-friendliness, security measures, confidence digital platforms, belief additional features, and trust technological adaptability. The findings highlight opportunities for improvement, emphasizing importance user-centric enhancements, robust...
<b>Background:</b> CFTR modulators have transformed Cystic Fibrosis (CF) care. However, there is limited knowledge on impact of exercise capacity. Reduced VO<sub>2</sub> at peak and ventilatory limitation indicated by low breathing reserve < 15% are common abnormalities in CF patients. <b>Aims:</b> To study the Kaftrio capacity children. <b>Methods:</b> Observational cohort study. Cardiopulmonary testing (CPET) was performed baseline after 6-8 months treatment. Results : 7 children...
We describe a case of 15-year-old girl diagnosed with relapsing polychondritis (RP) involvement the tracheobronchial tree, resulting in an increased difficulty breathing, hoarseness voice and stridor.Her required input multiple specialities including ear, nose throat, rheumatology, respiratory team intensive care. Airway assessment imaging showed glottic subglottic stenosis left bronchomalacia. Despite use steroids, cyclophosphamide rituximab, her symptoms progressed she was started on...
Improving communication between health-care professionals is essential for patient safety. This article outlines a quality improvement project carried out to improve the of medical handover on paediatric ward. The incorporated use SBAR (situation, background, assessment, recommendation) tool and job book highlight outstanding jobs in daily handover. showed an highlighted that standardized approach helped ensure continuity care patients.
Acute osteomyelitis of the clavicle is rare in paediatric age group. We treated a 5-year-old boy who presented initially with fever and left shoulder pain, subsequently developed swelling region clavicle. Group A Streptococcus (GAS) was isolated blood culture. MRI showed medial The child had incision drainage his clavicular collection. received intravenous benzylpenicillin oral cephalexin initial presentation; he 2 weeks ceftriaxone 4 penicillin thereafter resolution symptoms. There are no...
Background: We aimed to compare the prevalence of vitamin D deficiency and insufficiency in children with active or latent tuberculosis control population.Methods: This was a retrospective case study included 34 patients evidence exposure controls reviewed at Peterborough city hospital from October 2011 September 2013, who were matched regards age, gender ethnicity. All had blood investigations, chest X-ray, Quantiferon Gold Mantoux done time review along serum 25-hydroxyvitamin...
<h3>Background</h3> Dengue is a tropical disease and can cause complications including shock. The incidence of dengue increasing in UK due to increased travel endemic areas. We present the case 8 year old male child admitted with Haemorrhagic fever on return from India. <h3>Case Presentation</h3> being unwell for 10 days. He did not have any other symptoms such as abdominal pain, vomiting, diarrhoea, cough, cold or rashes. had returned Bangalore, India where he stayed 3 weeks. There was no...
<b>Introduction:</b> Children are frequently referred to ENT clinics with symptoms of sleep disordered breathing (SDB) presumed due enlarged tonsils and/or adenoids. However in many instances the clinical examination does not confirm parent reported and thereby creates uncertainty about need for ablative surgery. In these further assessment through polysomnography (PSG) helps guide management, but it is widely available. <b>Aims:</b> To identify from a questionnaire that correlated diagnosis...
<b>Introduction:</b> Children with tracheostomy are at a high risk of airway infections. Pseudomonas and staphylococcus aureus common lower pathogens in children tracheostomies. Data on clinical outcomes MRSA (methicillin resistant ) is limited. <b>Aims:</b> To review the incidence - methicillin sensitive (MSSA) our cohort correlation outcomes. <b>Methods:</b> We conducted retrospective data collection microbiology ( 2013-2018) including ventilated non-ventilated patients its length stay...