A5072341048- Climate variability and models
- Meteorological Phenomena and Simulations
- Neuroscience and Neuropharmacology Research
- Astrophysical Phenomena and Observations
- Atmospheric and Environmental Gas Dynamics
- Ion channel regulation and function
- Galaxies: Formation, Evolution, Phenomena
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- Hydrology and Drought Analysis
- Astrophysics and Cosmic Phenomena
- Nerve injury and regeneration
- Geophysics and Gravity Measurements
- Fish biology, ecology, and behavior
- Retinal Development and Disorders
- S100 Proteins and Annexins
- RNA Research and Splicing
- RNA modifications and cancer
- Cryospheric studies and observations
- Neural dynamics and brain function
- Astrophysics and Star Formation Studies
- Pulsars and Gravitational Waves Research
- Neurogenesis and neuroplasticity mechanisms
- Arctic and Antarctic ice dynamics
Met Office
2016-2025
American Academy of Forensic Sciences
2023
Phillips Exeter Academy
2017-2021
Cooperative Institute for Climate and Satellites
2020
North Carolina State University
2020
Yale University
2019
Swedish Meteorological and Hydrological Institute
2018
McGill University
1998-2017
Lunenfeld-Tanenbaum Research Institute
2017
Royal Adelaide Hospital
2003-2014
In this study, we present the collation and analysis of gridded land‐based dataset indices temperature precipitation extremes: HadEX2. Indices were calculated based on station data using a consistent approach recommended by World Meteorological Organization (WMO) Expert Team Climate Change Detection Indices, resulting in production 17 12 derived from daily maximum minimum observations. High‐quality situ observations over 7000 11,000 meteorological stations across globe obtained to calculate...
Abstract We present a new version of the Met Office Hadley Centre/Climatic Research Unit global surface temperature data set, HadCRUT5. HadCRUT5 presents monthly average near‐surface anomalies, relative to 1961–1990 period, on regular 5° latitude by longitude grid from 1850 2018. is combination sea‐surface (SST) measurements over ocean ships and buoys air weather stations land surface. These have been sourced updated compilations adjustments applied mitigate impact changes in SST measurement...
RasGRP, a guanyl nucleotide–releasing protein for the small guanosine triphosphatase Ras, was characterized. Besides catalytic domain, RasGRP has an atypical pair of “EF hands” that bind calcium and diacylglycerol (DAG)-binding domain. activated Ras caused transformation in fibroblasts. A DAG analog sustained activation Ras-Erk signaling changes cell morphology. Signaling associated with partitioning into membrane fraction. Sustained ligand-induced were absent when DAG-binding domain...
Using Chandra X-ray observations of 9 nearby, luminous ellipticals with good optical velocity dispersion measurements, we show that a tight correlation exists between the Bondi accretion rates calculated from data and estimated black hole masses, power emerging these systems in relativistic jets. The jet powers, inferred energies timescales required to inflate cavities observed surrounding emitting gas, can be related by law model. A significant fraction (2.2^{+1.0}_{-0.7} per cent, for...
In this study, we demonstrate that: ( i ) injection of an adenovirus (Ad) vector containing the brain-derived neurotrophic factor (BDNF) gene (Ad.BDNF) into vitreous chamber adult rats results in selective transgene expression by Müller cells; ii vitro , cells infected with Ad.BDNF secrete BDNF that enhances neuronal survival; iii vivo Ad-mediated functional cells, temporarily extends survival axotomized retinal ganglion (RGCs); 16 days after axotomy, injured retinas treated showed a...
We present the second update to a data set of gridded land-based temperature and precipitation extremes indices: HadEX3. This consists 17 12 indices derived from daily, in situ observations recommended by World Meteorological Organization (WMO) Expert Team on Climate Change Detection Indices (ETCCDI). These have been calculated at around 7,000 locations for 17,000 precipitation. The annual (and monthly) interpolated 1.875°×1.25° longitude-latitude grid, covering 1901–2018. show changes these...
(Abridged) We report on a consistent and comprehensive spectral analysis of the X-ray emission 25 Black Hole Binaries. All publicly available observations black hole binaries in RXTE archive were analysed. Three different types model fitted to investigate changes occurring during an outburst. For population, as well each binary outburst from binary, we construct two diagnostic diagrams. The Hardness Intensity/Luminosity Diagram (HID/HLD) is most useful when studying single binary. However,...
Abstract High-resolution spectra of Galactic black holes (GBHs) reveal the presence highly ionized absorbers. In one GBH, accreting close to Eddington limit for more than a decade, powerful accretion disc wind is observed be present in softer X-ray states and it has been suggested that can carry away enough mass energy quench radio jet. Here we report these winds, which may have outflow rates order inner rate or higher, are ubiquitous component jet-free soft all GBHs. We furthermore...
A large number of recent studies have aimed at understanding short-duration rainfall extremes, due to their impacts on flash floods, landslides and debris flows potential for these worsen with global warming. This has been led in a concerted international effort by the INTENSE Crosscutting Project GEWEX (Global Energy Water Exchanges) Hydroclimatology Panel. Here, we summarize main findings so far suggest future directions research, including: benefits convection-permitting climate...
Mr. President,—I need not tell you, Sir, nor the Fellows of this Society, that study human mind is a subject which has occupied attention greatest philosophers every age; I remind you how long was enveloped in shades mysticism, bewildered mazes metaphysical subtilty, amid dogmata conflicting systems. It to Locke we are so much indebted for dispelling mysticism schoolmen. Unshackled from tyranny ancient names, and regardless alike Aristotle his categories, discarded syllogism, instituted...
Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We have previously reported glycosylphosphatidylinositol-anchored form of ceruloplasmin expressed in the mammalian CNS. To better understand role homeostasis CNS, we generated gene-deficient (<i>Cp</i><sup>−/−</sup>) mouse. Adult<i>Cp</i><sup>−/−</sup> mice showed increased deposition several regions CNS such as cerebellum and brainstem. Increased lipid peroxidation was also seen some regions....
Myelin-associated glycoprotein (MAG) may play a role in the cellular interactions leading to myelination. Using monoclonal antibodies and conventional antisera against MAG, we have isolated cDNA clone from an expression library prepared rat brain mRNA. The identity of was confirmed by exact match between its nucleotide sequence two peptide sequences 13 9 amino acids that obtained Edman degradation CNBr fragments MAG. hybridized size species mRNA approximately 3.5 kilobases length. These...
The bacteriorhodopsin gene has been identified in a 5.3-kilobase restriction endonuclease fragment isolated from Halobacterium halobium DNA, using cloned cDNA as the probe. Of 1229 nucleotides whose sequence was determined genomic fragment, 786 correspond to structural of bacteriorhodopsin, 360 are upstream initiator methionine codon, and 83 downstream COOH terminus. codes for precursor 13 amino acids at NH2 terminus, 248 that present mature protein an additional aspartic acid This...
S100 protein is a calcium-binding found predominantly in the vertebrate nervous system. Genomic and complementary DNA probes were used conjunction with panel of rodent-human somatic cell hybrids to assign gene for β subunit distal half long arm human chromosome 21. This was identified as candidate sequence which, when expressed trisomic state, may underlie neurologic disturbances Down syndrome.
We analyse those objects in the Brightest 55 sample of clusters galaxies which have a short central cooling time and temperature drop. Such are likely to require some form heating. Where clear radio bubbles observed these clusters, their energy injection is compared X-ray rate. Of 20 requiring heating, at least 14 bubbles, implying duty cycle for bubbling activity 70 per cent. The average distance out can offset cooling, rheat, given by rheat/rcool= 0.86 ± 0.11 where rcool defined as radius...
Several cDNA clones coding for the high molecular weight (alpha) subunit of voltage-sensitive Na channel have been selected by immunoscreening a rat brain library constructed in expression vector lambda gt11. As will be reported elsewhere, amino acid sequence translated from DNA shows considerable homology to that Electrophorus electricus electroplax channel. inserts hybridized with low-abundance 9-kilobase RNA species brain, muscle, and heart. Sucrose-gradient fractionation poly(A) yielded...
Ceruloplasmin is a copper-containing ferroxidase that essential for normal iron homeostasis. Whereas ceruloplasmin in plasma produced and secreted by hepatocytes, the brain glycosylphosphatidylinositol (GPI)-anchored form of expressed on surface astrocytes. By using cDNA cloning approach, we have now determined GPI-anchored generated alternative RNA splicing. The splicing occurs downstream exon 18 replaces C-terminal 5 amino acids with an 30 signal GPI anchor addition. RNase protection...
Sodium channels encoded by the rat IIA cDNA clone [Auld, V. J., Goldin, A. L., Krafte, D. S., Marshall, Dunn, Catterall, W. A., Lester, H. Davidson, N. & R. J. (1988) Neuron 1, 449-461] differ at seven amino acid residues from those II [Noda, M., Ikeda, T., Kayano, Suzuki, H., Takeshima, Kurasaki, Takahashi, Numa, S. (1986) Nature (London) 320, 188-192]. When expressed in Xenopus oocytes, display a current-voltage relationship that is shifted 20-25 mV depolarizing direction relative to...
The effects of riluzole, a novel neuroprotective drug with anticonvulsant and anti-ischemic properties, were studied on currents carried by cloned rat brain IIA sodium channel alpha subunits expressed in Xenopus oocytes. (i) When the oocytes held at strongly hyperpolarized potentials to close channels riluzole was added external solution, current elicited test depolarizing pulses reduced within few minutes recovered upon washout riluzole. Although reduced, did not shift peak current-voltage...
Editors note: For easy download the posted pdf of State Climate for 2012 is a very low-resolution file. A high-resolution copy report available by clicking here. Please be patient as it may take few minutes file to download.
Anti-peptide antibodies that distinguish between the rat brain sodium channel subtypes referred to as RI and RII were prepared used determine their relative expression in nerve muscle tissues. Sodium channels purified from are approximately 18% 80% RII. In brain, subtype is preferentially expressed with RI/RII ratios ranging 0.07 hippocampus 0.17 cerebral cortex. The more caudal areas of central nervous system values 0.98 for medulla oblongata 2.2 spinal cord. Expression additional...
Abstract. HadISDH.2.0.0 is the first gridded, multi-variable humidity and temperature in situ observations-only climate-data product that homogenised annually updated. It provides physically consistent estimates for specific humidity, vapour pressure, relative dew point temperature, wet bulb depression temperature. a monthly mean gridded (5° by 5°) with uncertainty account spatio-temporal sampling, climatology calculation, homogenisation irreducible random measurement effects. tool long-term...