A5033983296- Occupational and environmental lung diseases
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Aluminum toxicity and tolerance in plants and animals
- Breast Cancer Treatment Studies
- Occupational exposure and asthma
- NF-κB Signaling Pathways
- Biomarkers in Disease Mechanisms
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
University of Fribourg
2015-2023
The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for diagnosis of malignant mesothelioma (MM). MM a very aggressive tumor strongly linked to asbestos exposure with no existing cure so far. mechanisms regulation, well its distinct function in are still poorly understood.We searched transcription factors binding CALB2 promoter modulating expression. For this, DNA-binding assays followed by peptide shotgun-mass...
Mesothelial cells are susceptible to asbestos fiber-induced cytotoxicity and on longer time scales transformation; the resulting mesothelioma is a highly aggressive neoplasm that considered as incurable at present Zucali et al. (Cancer Treatment Reviews 37:543-558, 2011). Only few murine cell culture models of immortalized mesothelial lines exist date. We generated SV40-immortalized derived from wild-type (WT) neurofibromatosis 2 (merlin) heterozygote (Nf2+/-) mice, both commonly used...
// Janine Wörthmüller 1 , Walter Blum 1, 2 Laszlo Pecze Valérie Salicio and Beat Schwaller Unit of Anatomy, Section Medicine, University Fribourg, 1700 Switzerland Genetica AG, 8001 Zurich, Correspondence to: Schwaller, email: beat.schwaller@unifr.ch Keywords: calretinin; malignant mesothelioma; FAK signaling; EMT Received: August 19, 2018 Accepted: October 25, Published: November 20, ABSTRACT Calretinin (CR) is used as a positive marker for human mesothelioma (MM) essential cell...
Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent a tumor suppressive function in several cancers of origin. Here we report, based on experimental results and human breast cancer (BC) patients’ gene expression data, MAGI1 highly expressed acts as suppressor estrogen receptor (ER)+/HER2− but not HER2+ or triple negative (TNBC). Within the ER+/HER2− subset, high associates...
Malignant mesothelioma (MM) is an aggressive asbestos-linked neoplasm, characterized by dysregulation of signaling pathways. Due to intrinsic or acquired chemoresistance, MM treatment options remain limited. Calretinin a Ca2+-binding protein expressed during tumorigenesis that activates the FAK pathway, promoting invasion and epithelial-to-mesenchymal transition. Constitutive calretinin downregulation decreases cells’ growth survival, impairs tumor formation in vivo. In order evaluate early...
Calretinin (CR; CALB2) belonging to the family of EF-hand Ca2+-binding proteins (CaBP) is widely used as a positive marker for identification human malignant mesothelioma (MM) and functionally was suggested play critical role during carcinogenesis this highly aggressive asbestos-associated neoplasm. Increasing evidence suggests that CR not only acts prototypical Ca2+ buffer protein, i.e., limiting amplitude signals but also sensor. No studies have yet investigated whether other closely...
MAGI1 acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer (BC), and its loss correlates with more aggressive phenotype. To identify the pathways events affected by loss, we deleted gene ER+ MCF7 BC cell line performed RNA sequencing functional experiments vitro. Transcriptome analyses revealed sets biological processes related to signaling, cycle, DNA damage responses loss. Upon exposure TNF-α/IFN-γ, KO cells entered deeper level of quiescence/senescence compared...
Calretinin is the most widespread positive marker for immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a blood-based biomarker. Functionally, evidence has accumulated that calretinin might be implicated in MM tumorigenesis. We aimed identify (CR; Calb2) murine reactive mesothelial cells granuloma from asbestos-exposed NF2+/− mice, line heterozygous tumor suppressor merlin (NF2), used mouse model. Additionally, we sought ascertain presence cell...