A5073343596- Glycosylation and Glycoproteins Research
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Phagocytosis and Immune Regulation
- Toxin Mechanisms and Immunotoxins
- Cell Adhesion Molecules Research
- Growth Hormone and Insulin-like Growth Factors
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
European Molecular Biology Laboratory
2023
University of Bristol
2020-2021
The α1-acid glycoprotein (AGP) is an abundant blood plasma protein with important immunomodulatory functions coupled to endogenous and exogenous ligand-binding properties. Its affinity for many drug-like structures, however, means AGP can have a significant effect on the pharmokinetics pharmacodynamics of numerous small molecule therapeutics. Staurosporine, its hydroxylated forms UCN-01 UCN-02, are kinase inhibitors that been investigated at length as antitumour compounds. Despite their...
Abstract Thrombospondin type-1 domain-containing 7A (THSD7A) is a large extracellular protein that found in podocyte foot processes of the kidney glomerulus. It has been established as causative autoantigen membranous nephropathy. Amongst predicted 21 thrombospondin repeat domains its segment, highest frequency autoimmune response associated with two N-terminal domains. Here, we show antibodies against this THSD7A segment mice induce typical clinical and morphological signs The...