A5039601101- Renal Diseases and Glomerulopathies
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Mechanical and Optical Resonators
- Force Microscopy Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Muscle and Compartmental Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Medical Imaging and Pathology Studies
- Nutritional Studies and Diet
- MRI in cancer diagnosis
- Plant and Biological Electrophysiology Studies
- Near-Field Optical Microscopy
- Cardiovascular Health and Disease Prevention
- Iron Metabolism and Disorders
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Renal and related cancers
- Erythropoietin and Anemia Treatment
University Medical Center Hamburg-Eppendorf
2021-2025
Universität Hamburg
2021-2025
University Hospital Heidelberg
2024
University Medical Center
2024
Sorbonne Université
2024
Inserm
2024
Aarhus University
2024
Heidelberg University
2024
Johns Hopkins University
2024
Howard Hughes Medical Institute
2018-2021
Minimal change disease and primary focal segmental glomerulosclerosis in adults, along with idiopathic nephrotic syndrome children, are immune-mediated podocytopathies that lead to syndrome. Autoantibodies targeting nephrin have been found patients minimal disease, but their clinical pathophysiological roles unclear.
Conflict of interestFEH, TBH and NMT report a pending patent regarding the measurement anti-
Hair cells, the sensory receptors of inner ear, respond to mechanical forces originating from sounds and accelerations. An essential feature each hair cell is an array filamentous tip links, consisting proteins protocadherin 15 (PCDH15) cadherin 23 (CDH23), whose tension thought directly gate cell's transduction channels. These links are considered far too stiff represent gating springs that convert bundle displacement into capable opening channels, no mechanism has been suggested through...
Adeno-associated virus (AAV) is a promising in vivo gene delivery platform showing advantages delivering therapeutic molecules to difficult or undruggable cells. However, natural AAV serotypes have insufficient transduction specificity and efficiency kidney Here, we developed an evolution-directed selection protocol for renal glomeruli identified what believe be new vector termed AAV2-GEC that specifically efficiently targets the glomerular endothelial cells (GEC) after systemic...
Effective management of chronic kidney disease (CKD), a major health problem worldwide, requires accurate and timely diagnosis, prognosis progression, assessment therapeutic efficacy, and, ideally, prediction drug response. Multiple biomarkers algorithms for evaluating specific aspects CKD have been proposed in the literature, many which are based on small number samples. Based evidence presented relevant studies, comprehensive overview different applicable clinical implementation is...
Autoantibodies against the podocyte protein nephrin were recently identified in a pediatric cohort primarily comprising steroid-sensitive (SSNS) and steroid-dependent (SDNS) nephrotic syndrome (NS). However, their prevalence across all NS subtypes, particularly steroid-resistant (SRNS), relation to therapy response remain need be determined advance pathophysiological understanding refine treatment strategies. A multicenter study measuring anti-nephrin autoantibodies samples from children...
Abstract Recent studies have identified autoantibodies targeting the podocyte protein nephrin in patients with primary podocytopathies such as minimal change disease (MCD), focal segmental glomerulosclerosis (pFSGS), post-transplant recurrent FSGS (rFSGS) and childhood idiopathic nephrotic syndrome (INS). These antibodies bind directly influence downstream signaling immense effect on podocytes’ cellular structure function, substantially changing our understanding of antibody-mediated...
The 14th International Podocyte Conference took place in Philadelphia, Pennsylvania, USA from May 23 to 26, 2023. It commenced with an early-career researchers' meeting on 23, providing young scientists a platform present and discuss their research findings. Throughout the main conference, 29 speakers across 9 sessions shared insights podocyte biology, glomerular medicine, novel technologic advancements, translational approaches. Additionally, event featured 3 keynote lectures addressing...
Abstract In a high-speed single-molecule experiment with force probe, protein is tethered between two substrates that are manipulated to exert on the system. To avoid nonspecific interactions and nearby substrates, usually attached through long, flexible linkers. This approach precludes measurements of mechanical properties high spatial temporal resolution, for rapidly exerted forces dissipated into Because mammalian hearing operates at frequencies reaching tens hundreds kilohertz, processes...
Abstract Thrombospondin type-1 domain-containing 7A (THSD7A) is a large extracellular protein that found in podocyte foot processes of the kidney glomerulus. It has been established as causative autoantigen membranous nephropathy. Amongst predicted 21 thrombospondin repeat domains its segment, highest frequency autoimmune response associated with two N-terminal domains. Here, we show antibodies against this THSD7A segment mice induce typical clinical and morphological signs The...
Hair cells, the sensory receptors of inner ear, respond to mechanical forces originating from sounds and accelerations. An essential feature each hair cell is an array filamentous tip links, consisting proteins protocadherin 15 (PCDH15) cadherin 23 (CDH23), whose tension thought directly gate cell's transduction channels. These links are considered far too stiff represent gating springs that convert hair-bundle displacement into capable opening channels, no mechanism has been suggested...
Abstract In a high-speed single-molecule experiment, protein is tethered between two substrates that are manipulated to exert force on the system. To avoid nonspecific interactions and nearby substrates, usually attached through long, flexible linkers. This approach precludes measurements of mechanical properties with high spatial temporal resolution, for rapidly exerted forces dissipated into Because mammalian hearing operates at frequencies reaching tens hundreds kilohertz, processes occur...
Die immense Bedeutung des Bluthochdrucks erwächst nicht nur aus der Häufigkeit Erkrankung, sondern besonders dem mit Erkrankung einhergehenden erhöhten kardiovaskulären Risiko. Bis zu 10 Millionen Todesfälle pro Jahr gehen weltweit auf Blutdruck zurück. Diese Übersicht über die möglichen Ursachen, Diagnostik und leitliniengerechte Therapie soll helfen, Versorgung von Patienten arterieller Hypertonie verbessern.