Purpose Radiotherapy is a cornerstone of breast cancer (BRCA) treatment. Accurately predicting tumor radiosensitivity critical for optimizing therapeutic outcomes and personalizing treatment strategies. DNA repair pathways are key determinants radiotherapy response. Thus, we aimed to develop novel repair-related model identify potential targets enhancing efficacy. Methods A retrospective study was conducted using data from 942 BRCA patients TCGA database. model, comprising index, developed...

<title>Abstract</title> Background Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumours arose from esophagus. ESCC highly lethal due to late onset symptoms and therefore, there an urgent need deepen molecular understanding this disease identify potential prognostic biomarkers further guide treatment. As a type non-coding RNAs, competing endogenous RNA (ceRNA) reveals novel mechanism interaction between RNAs in various cancers. However, ceRNA regulatory...

Kallistatin, which protects organs and cells against inflammation, fibrosis oxidative stress, is mainly synthesized secreted in liver. However, its relationship to human liver disease remains unclear. The purpose of this study was explore the between serum kallistatin clinical evidence both cirrhosis hepatocellular carcinoma (HCC), determine if levels could be used as a diagnostic indicator hepatic health status, especially (LC). Our cohort consisted 115 patients with clinically proven (LF),...

Abstract Currently, immunotherapy has entered the clinical diagnosis and treatment guidelines for colon cancer, but existing markers cannot predict effectiveness of well. This study utilized TCGA-COAD queue to perform differential gene analysis on high low-mutation burden samples, screen differentially expressed genes (DEGs). To explore new molecular or predictive models by using DEGs NMF classification prognostic model construction. Through systematic bioinformatics analysis, cohort was...

Yes-associated protein (YAP), a key player of the Hippo pathway, has been identified to have more and important roles in tumorigenesis may be an biomarker for cancer therapy. YAP is bladder cell migration, metastasis, drug resistance; however, its function stem cells remains unknown.The aim this work was examine expression role cells.We that level significantly enriched compared noncancer population. Moreover, effect on self-renewal examined by siRNA silencing approach. In addition, we...

Abstract Background Endometrial cancer (EC) is the most frequent malignancy of female genital tract worldwide. Our study aimed to construct an effective protein prognostic signature predict prognosis and immunotherapy responsiveness in patients with endometrial carcinoma. Methods Protein expression data, RNA profile data mutation were obtained from The Cancer Proteome Atlas (TCPA) Genome (TCGA). Prognosis-related proteins EC screened by univariate Cox regression analysis. Least absolute...

Follicular thyroid carcinoma (FTC) is the second most common cancer of and easily develops into distant metastasis. PD-L1 known to be associated with carcinogenesis progression carcinoma. Our study aimed investigate biological functions identify miRNAs that were responsible for modulating activity PD-L1.A total 72 patients FTC at The Second Affiliated Hospital Fujian Medical University enrolled in this retrospective study. Immunohistochemical (IHC) assay was used measure expression FTC....

// Jianqing Lin 1 , Deqiang Fu Yijun Dai Jianguang and Tianwen Xu Department of Medical Oncology, The Second Affiliated Hospital Fujian University, Quanzhou, Fujian, China Correspondence to: Xu, email: xutianwen53@126.com Keywords: ESCC, Mcl-1, A-1210477 Received: January 10, 2017&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Accepted: March 21, Published: June 28, 2017 ABSTRACT Esophageal squamous cell carcinoma (ESCC) has a high morbidity in China, accounting for 90% all esophageal cases. Hence,...

Circular RNAs (circRNAs), including circ_0000033, were shown to be abnormally expressed in breast cancer (BC) and play an important regulatory function the development of this cancer. This study aimed investigate action mechanism circ_0000033 BC carcinogenesis. Specifically, levels genes proteins analyzed using quantitative real-time PCR (qRT-PCR) western blotting. Circ_0000033 was highly tissues cells. Properties cells with modified expression characterized vitro colony formation assay, EdU...

Esophageal carcinoma is one of the most prevalent cancers with high rate mortality worldwide. Intravenous and oral-based chemotherapeutic regimens were employed; however all current treatment modalities are largely unsuccessful. Therefore main aim this work was to demonstrate antitumor efficacy docetaxel (DTX)-loaded trimethyl chitosan (TMC-DTX) against EC9701 esophageal squamous cancer cells. We showed a superior anti-proliferative activity for TMC-DTX cells upon incubation 24, 48, 72 h....

Malignant mesothelioma (MM) is a relatively rare and highly lethal tumor with few treatment options. Thus, it important to identify prognostic markers that can help clinicians diagnose earlier assess disease activity more accurately. Alternative splicing (AS) events have been recognized as critical signatures for diagnosis in multiple cancers, including MM.We systematically examined the AS clinical information of 83 MM samples from TCGA database. Univariate Cox regression analysis was used...

We aimed to probe carcinogenic genes associated with colon adenocarcinoma (COAD) development.The gene expression profile of COAD were downloaded from TCGA. Differentially expressed (DEGs) identified; GO and KEGG pathway enrichment analyzed. Applying the up-mRNA-and-down-miRNA pairs down-mRNA-and-up-miRNA pairs, miRNA target network was generated. The important further analyzed towards influence on overall survival immune infiltration. In addition, essential miRNAs selected for validation...

To investigate the effect of metformin on proliferation and apoptosis HER-2-positive breast cancer cell line SKBR3 explore possible mechanism its action.SKBR3 cells were treated with different concentrations (20-120 μmol/L) metformin, changes in colony formation ability assessed using CCK-8 assay crystal violet staining, respectively. Flow cytometry was performed to analyze cycle changes. Real-time fluorescent quantitative PCR (qRT-PCR) used detect mRNA expressions YAP, TAZ, EGFR, CTGF,...

Background: The chemokine signaling pathway plays an essential role in the development, progression, and immune surveillance of lung squamous cell carcinoma (LUSC). Our study aimed to systematically analyze signaling-related genes (CSRGs) LUSC patients with stage I-III disease develop a prediction model predict prognosis therapeutic response. Methods: A total 610 from three independent cohorts were included our study. Least absolute shrinkage selection operator (LASSO) stepwise multivariate...

Our purpose is to verify that miR-146b-3p targets the downstream transcript TNFAIP2 in order reveal machinery underlying miR-146b-3p/TNFAIP2 axis regulating acute myeloid leukaemia (AML) differentiation. Bioinformatics analyses were performed using multiple databases and R packages. The CD11b+ CD14+ cell frequencies detected flow cytometry immunofluorescence staining. protein expression was evaluated western blotting, immunocytochemistry qRT-PCR conducted detect of miR-146b-3p. its...

This study aims to explore the impact of FTX, a once-prominent cryptocurrency platform that boasted over 1 million active users globally and held third-largest market share in trading volume, on stability entire United States. FTX's subsequent bankruptcy has reverberated through various assets, including major cryptocurrencies like Bitcoin Ethereum, directly influencing expansive pension industry within Considering this, our research endeavors conduct comprehensive examination how insolvency...

Background Bladder cancer (BLCA) is a prevalent urinary tract malignancy with high propensity for recurrence and chemoresistance. The molecular mechanisms underlying its progression response to therapy have not been fully elucidated. Methods We conducted multifaceted analysis, integrating immunohistochemical (IHC) staining, bioinformatics evaluation using TCGA CCLE databases, in vitro assays the BLCA cell lines 5637 T24. RAC3 expression was assessed relative clinical pathological features....

Purpose This study aimed to develop and validate a model for accurately assessing the risk of distant metastases in patients with gastric cancer (GC). Methods A total 301 (training cohort, n = 210; testing 91) GC were retrospectively collected. Relevant clinical predictors determined through application univariate multivariate logistic regression analyses. Then was established. Venous phase computed tomography (VPCT) images utilized extract radiomic features, relevant features selected using...

&lt;b&gt;&lt;i&gt;Summary&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Background: &lt;/i&gt;&lt;/b&gt;Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in southern China. In this study, we compared clinical efficacy and toxicity cisplatin with nolatrexed (LP) or 5-fluorouracil (FP) for NPC. &lt;b&gt;&lt;i&gt;Patients Methods: &lt;/i&gt;&lt;/b&gt;33 patients metastatic NPC were randomized to LP FP regimens. The regimen consisted continuous intravenous infusions 740...

Objective To assess the rationality of using CT for clinical staging in esophageal carcinoma.Methods 103 carcinoma patients with radical resection were selected,patients examined by before surgery.To compare on basis findings pathology.Results Lymph node enlargement mentioned 29 cases (28.2 ％) surgery,but 70 (68.0 pathology.The and pathology inconsistent (x2 =11.719,P =0.001).Although which positive could be later (Z =-3.04,P =0.002),there was no correlation between two methods =10.885,r...