A5077094281- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cutaneous Melanoma Detection and Management
- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Soft tissue tumor case studies
- Genetic and rare skin diseases.
- Tumors and Oncological Cases
- Cutaneous lymphoproliferative disorders research
- Neurofibromatosis and Schwannoma Cases
- Histiocytic Disorders and Treatments
- Herpesvirus Infections and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vascular Malformations and Hemangiomas
- Autoimmune Bullous Skin Diseases
- Melanoma and MAPK Pathways
- Oral Health Pathology and Treatment
- Genital Health and Disease
- Helicobacter pylori-related gastroenterology studies
- Viral-associated cancers and disorders
- Urologic and reproductive health conditions
- Nail Diseases and Treatments
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
University of Ljubljana
2016-2025
Ljubljana University Medical Centre
1997-2020
University Medical Center
2020
Institut za Reumatologiju
2016-2020
St Thomas' Hospital
2007-2018
In-Q-Tel
2015
St. John's University
2009
College of Nursing in Celje
2008
Institute of Oncology Ljubljana
1997-2006
Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation potential for malignant transformation aggressive behaviour. We present the genomic analysis of 75 samples from 57 representative patients including 15 cylindromas, 17 spiradenomas, 2 cylindroma-spiradenoma hybrid tumors, 24 low- high-grade spiradenocarcinoma cases, together morphologically benign precursor regions these cancers. reveal somatic or germline alterations CYLD gene in 15/15...
The authors report a small series of sebaceous carcinoma developing in nevus sebaceus Jadassohn (also known as organoid nevus) and analyze similar cases reported the literature. All our patients were females (age range 57-71 years; median 60 years) who had on scalp, face, or nuchal area, rest which was recognized clinically and/or histologically. carcinomas manifested unquestionable architectural (asymmetry, invasive growth) cytological features (cellular nuclear pleomorphism, plentiful...
Anogenital warts and laryngeal papillomas are two most important benign tumors etiologically linked with HPV. In the study, which included both largest number of papilloma tissue specimens (152 from 152 patients) to date prospectively collected histologically confirmed anogenital obtained genders (422 315 patients), HPV DNA was detected in 413/422 (97.9%) 139/152 (91.4%) papillomas. HPV-6 and/or HPV-11 were 291/315 (92.4%) patients 138/152 (90.8%) papillomas, indicating that great majority...
The aim of this randomized controlled trial was to evaluate the safety and efficacy neodymium: yttrium aluminum garnet laser treatment lichen sclerosus (LS) by comparing it with topical corticosteroid treatment.A total 40 female patients vulvar LS were 1:1 into a study (laser) group control (topical corticosteroids) group. received three treatments. Blinded evaluators evaluated biopsies graded improvement on clinical photographs at baseline 3 months. Patients intensity symptoms 0 10 visual...
Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-RSCNs) are an emerging category of rare soft tissue tumors recently recognized by the World Health Organization Classification Soft Tissue and Bone Tumours. NTRK-RSCNs mostly affect superficial tissues extremities trunk, they can occur across a broad age range. These exhibit wide morphologic spectrum, often mimicking other mesenchymal tumors. Recognition is crucial for targeted therapy in selected cases, given...
We report 18 cases of cutaneous angiosarcoma with predominant or exclusive epithelioid morphology. Both sexes were similarly affected. Patients' ages ranged from 2 to 97 years, median 77.5 years; pediatric patients. In elderly patients scalp facial lesions and arising within irradiated breast skin predominated. Limb seen in younger Microscopically, the tumors composed packed polygonal cells focal evidence endothelial differentiation. Diverging phenotypes included syncytial growth large clear...
Clear cell sarcoma is a unique soft tissue tumor with distinct microscopic features that include nested or fascicular pattern of spindle cells accompanied by larger wreath-like giant scattered throughout. It harbors EWSR1-ATF1 gene fusion secondary to t(12;22)(q13;q12) translocation. Recently, it was reported clear can occur in the skin and mimic broad spectrum entities, including melanoma. Here, we describe 3 new cases skin, all which were confirmed molecularly. The patients, 12-year-old...
Fibro-osseous pseudotumor (FP) of the digit is a rare, non-neoplastic heterotopic ossifying lesion involving subcutaneous tissues digits. To date, there are only few published series in literature. Our study 17 cases, retrieved from authors' referral archives, shows that condition chiefly affects young to middle-aged adults (median = 34 years), with slight female predominance and involves fingers (n 8) toes 8). One identical was identified on forehead 1). Lesional size ranges 0.8 5.6 cm....
Secretory carcinoma of the skin is a rare adnexal carcinoma, which morphologically and immunohistochemically identical to secretory breast associated with presence t (12;15) translocation, resulting in ETV6-NTRK3 gene fusion. Nineteen cases primary cutaneous have been previously published literature. In this study, we describe 6 new skin. The study group consisted 5 female patients 1 male patient, ranging age from 57 98 years (mean: 74.2, median: 74). Locations included axilla (2), neck,...
Although infection with Helicobacter pylori in children mostly induces asymptomatic chronic gastritis, the clinical outcome of H is generally unpredictable. To identify risk subgroup infected who can progress toward serious gastrointestinal disease, we assessed prevalence virulence genes cagA, vacA, and iceA from southeastern Europe correlated their presence severity histological changes stomach.A total 165 (age range 4-18 years, mean 13 years) were studied for a 6-year period. Virulence...
Aims Epithelioid malignant peripheral nerve sheath tumour (E‐ MPNST ) is a distinctive variant of characterized by the predominance epithelioid cells, diffuse S100 positivity and infrequent association with neurofibromatosis type 1. The aim this study was to further delineate clinicopathological features cutaneous E‐ , correlate them disease outcome discuss differential diagnosis. Methods results We analysed 11 s (six males, five females, median age 49 years, size 1.6 cm). Tumours showed...
Summary It has been shown for hepatitis C virus ( HCV ) infection that host mi RNA s contribute to the replication of viral genome. However, clinical impact these and many other cellular on in humans is still largely unclear. We therefore analysed expression miR‐122 , miR‐126 miR‐181a miR‐136 ‐infected patients. The study included liver biopsies 65 patients infected with different genotypes (gt 1, gt 1a, 1b, 3 4) nine noninfected individuals. Expression analysis miRNAs was performed by qPCR...
Molluscum contagiosum (MC) manifests as small, umbilicated papules caused by the molluscum virus (MCV). The extent of clinical misdiagnosis MC is unknown. Combined clinical, histopathological, and virological evaluation 203 consecutive patients with diagnosis treated at a university hospital during 5-year period showed correct in 188 (92.6%) patients. All 15 clinically misdiagnosed lesions were histopathologically virologically confirmed either common or anogenital warts different human...