A5018457351- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Signaling Pathways in Disease
- Calpain Protease Function and Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Biochemical and biochemical processes
- Ginkgo biloba and Cashew Applications
- Immune Response and Inflammation
- Medicinal Plants and Neuroprotection
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2020-2024
Institute of Physiologically Active Compounds
2018-2020
Cardiff University
2020
Abstract Previous studies of the alpha-synuclein null mutant mice on C57Bl6 genetic background have revealed reduced number dopaminergic neurons in their substantia nigra pars compacta (SNpc). However, presence genomes studied mouse lines additional modifications that affect expression genes located a close proximity to alpha-synuclein-encoding Snca gene makes these data open various interpretations. To unambiguously demonstrate absence is primary cause observed deficit neurons, we employed...
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...
Aggregated forms of α-synuclein are core components pathohistological inclusions known as Lewy bodies in substantia nigra (SN) neurons patients with Parkinson's disease (PD). The role selective loss SN dopaminergic (DNs) PD is studied mice knocked out the gene. new mouse strain delta flox KO a constitutive knockout gene models end point vivo deletion conditional and has no foreign sequence modified genomic locus, thus differing from all other strains. effect neurotoxin...
S.
Aim . To study the expression of glial fibrillary acidic protein (GFAP) and ionized calcium-binding adapter molecule 1 (Iba1) in cerebral cingulate retrosplenial cortex mice on Day 5 after intraperitoneal (i.p.) administration bacterial lipopolysaccharide (LPS) at dose with no nervous tissue inflammation provoked. Materials methods The work was performed 10 female C57BL/6 aged 90 ± 3 days. At same time for 4 days, animals group were intraperitoneally injected saline (0.9% NaCl), 2 E. coli...
Целью данных исследований явилось изучение влияния гимантана (N-(2-адамантил)-гексаметиленимина гидрохлорида) на уровень провоспалительных цитокинов IL-1β, IL-6, интерферона-γ (ИФН-γ) и фактора некроза опухоли-α (ФНО-α) в нигрокаудатном комплексе мышей ранней поздней клинической фазе экспериментального паркинсонического синдрома (ПС), для выяснения его антипаркинсонического эффекта. Методы исследования: Раннюю позднюю клиническую фазу ПС создавали у линии C57BL/6J внутрибрюшинным введением...
Использование экспериментальных моделей на животных является чрезвычайно ценным методом изучения патогенеза заболеваний человека и используется для разработки их эффективной терапии. В отличие от изолированных in vitro, использование в качестве модельной системы оказалось более продуктивным мультифакториальных или болезней, влияющих несколько систем организма. Данный метод особенно актуален отношении использования vivo понимания патофизиологических механизмов расстройств центральной нервной...
In the present study we analyzed uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from dorsal striatum mice with constitutive inactivation all three synuclein-coding genes wild type mice. Synuclein deficiency substantially compromised this neurotransmitter whereas had no effect on synaptosomal uptake.
Целью данной работы являлась оценка выживаемости популяции зрелых дофаминергических (ДА-ергических) нейронов чёрной субстанции двух альфа-синуклеин нокаутных линий мышей Abel-KO и ΔFlox-KO, а также бессинуклеиновых животных abg-КО в условиях МФТП-токсического моделирования паркинсонического синдрома. Методы исследования: Водный раствор нейротоксина МФТП вводили 3-месячным мышам внутрибрюшинно дозе 30 мг/кг ежедневно течение 5 дней по субхроническому протоколу. Через 21 день после последней...
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...