A5089055689- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Pituitary Gland Disorders and Treatments
- Alzheimer's disease research and treatments
- Neuroendocrine Tumor Research Advances
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Calpain Protease Function and Regulation
- Prion Diseases and Protein Misfolding
- Cholinesterase and Neurodegenerative Diseases
- Neurological disorders and treatments
- Signaling Pathways in Disease
- Parathyroid Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Vitamin D Research Studies
Institute of Physiologically Active Compounds
2013-2020
Cardiff University
2015-2020
Pushchino State Institute of Natural Sciences
2013
The etiology and pathogenesis of Parkinson's disease (PD) are tightly linked to the gain-of-function α-synuclein. However, gradual accumulation α-synuclein aggregates in dopaminergic neurons substantia nigra pars compacta (SNpc) leads depletion functional pool soluble α-synuclein, therefore, creates loss-of-function conditions, particularly presynaptic terminals these neurons. Studies how this late-onset a protein involved many important steps neurotransmission contributes PD progression...
Dimebon has been tested as a potential modifier of Alzheimer's disease (AD), resulting in mixed clinical trial outcomes. Originally utilized an antihistamine, was later found to ameliorate AD symptoms initial human trials. Although subs
Abstract Pathological modification of α-synuclein is believed to be an important event in pathogenesis Parkinson’s disease and several other neurodegenerative diseases. In normal cells this protein has been linked many intracellular processes pathways. However, neither function neuronal certain types nor its exact role the well understood, which largely due limitations animal models used for studying protein. We produced validated novel mouse lines manipulating expression endogenous Snca...
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...
α-Synuclein is involved in many important molecular processes neuronal cells and their synapses, its malfunction has been linked to the development of Parkinson’s certain other neurodegenerative diseases. Animal models allowing tightly monitored conditional inactivation encoding gene, Snca, are indispensible for studies aimed at understanding normal function α-synuclein various populations role pathogenesis We have recently reported production several novel mouse lines manipulating...
In the present study we have used a transgenic mice overexpressing an amyloidogenic protein, gamma-synuclein, in nervous system to address effect of dimebon on proteinopathy progression. Neuroprotective chronic administration these at organismal level was confirmed by increased lifespan. Using histological and biochemical approaches demonstrated that reduced number amyloid inclusions spinal cord animals decreased content ubiquitinated proteins detergent-insoluble fractions. These effects are...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...
Lesion of the dopaminergic neurons nigrostriatal system is a key feature Parkinson's disease (PD). Alpha-synuclein protein that major component Lewy bodies, histopathological hallmarks PD, and involved in regulation dopamine (DA) neurotransmission. Previous studies knockout mice have shown inactivation alpha-synuclein gene can lead to reduction number DA substantia nigra (SN). SN are known be most affected PD patients whereas neighboring ventral tegmental area (VTA) much less susceptible...