A5101456133- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Alzheimer's disease research and treatments
- Acupuncture Treatment Research Studies
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Traditional Chinese Medicine Studies
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Healthcare and Venom Research
- Scoliosis diagnosis and treatment
- Medicinal Plants and Neuroprotection
- Surfactants and Colloidal Systems
- Neurological Disease Mechanisms and Treatments
- Pesticide Exposure and Toxicity
- Nuclear Physics and Applications
- Pelvic and Acetabular Injuries
- Petroleum Processing and Analysis
- Metabolomics and Mass Spectrometry Studies
- Cleft Lip and Palate Research
- Phytochemistry and Biological Activities
- dental development and anomalies
- Cardiovascular Function and Risk Factors
University of Minnesota
2020-2024
Shandong University
2024
Sinopec (China)
2007-2024
Southwest University of Science and Technology
2024
Mayo Clinic
2023
Xuzhou Medical College
2020-2023
Ningbo Dahongying University
2020
University of South China
2007-2018
First Affiliated Hospital of University of South China
2007-2018
Hubei University of Chinese Medicine
2009-2017
Cypermethrin, one kind of pyrethroid pesticides, has been shown to act as endocrine-disrupting chemicals (EDCs). The purpose this study was explore the roles Sertoli cell apoptosis through mitochondrial pathway associated with calcium (Ca2+) in cypermethrin-induced male reproductive toxicology. mouse cells TM4 were cultured 0 μM, 10 20 40 μM and 80 cypermethrin. We used flow cytometry, Fluo-4 AM, western blot JC-1 Assay Kit examine apoptosis, intracellular Ca2+, expressions apoptotic...
Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases. It a chronic inflammatory process characterised by airway obstruction and progressive inflammation, associated with difficulty breathing insensitivity to corticosteroid therapy. Although there some preliminary evidence suggest beneficial effect acupuncture on COPD, its mechanism action has not been investigated. Our aim was examine anti-inflammatory effects in rat model COPD induced exposure cigarette smoke...
Osteosarcoma (OS), a common and primary malignant bone tumor, is characterized by highly aggressive potency. Baicalein, bioactive flavone isolated from Scutellaria baicalensis Georgi, has been shown to inhibit the progression of numerous tumors, including OS. However, mechanisms which baicalein protects against OS are still largely unknown. The results present study showed that administration significantly inhibited proliferation, migration invasion promoted apoptosis in MG‑63 Saos‑2 cells....
Cypermethrin, an extensively used pyrethroid pesticide, is regarded as one of many endocrine-disrupting chemicals (EDCs) with anti-androgenic activity to damage male reproductive systems. We previously found cypermethrin-induced apoptosis in mouse Sertoli cells TM4. hypothesized TM4 by the endoplasmic reticulum (ER) pathway. This study aimed explore roles ER pathway cells. The were treated cypermethrin for 24 h at various concentrations (0 µM, 10 20 40 and 80 µM). Flow cytometry was test...
Aberrant insulin signaling has been considered one of the risk factors for development Alzheimer's disease (AD) and drawn considerable attention from research community to further study its role in AD pathophysiology. Herein, we describe an insulin-based novel positron emission tomography (PET) probe, [68Ga]Ga-NOTA-insulin, noninvasively AD. The developed PET probe [68Ga]Ga-NOTA-insulin showed a significantly higher uptake (0.396 ± 0.055 SUV) mouse brain compared normal (0.140 0.027 at 5 min...
Background: A strong body of evidence suggests that cerebrovascular pathologies augment the onset and progression Alzheimer’s disease (AD). One distinctive aspect this dysfunction is degeneration brain pericytes—often overlooked supporting cells blood-brain barrier endothelium. Objective: The current study investigates influence pericytes on gene protein expressions in endothelium, which expected to facilitate identification pathophysiological pathways are triggered by pericyte loss lead AD....
The blood-brain barrier (BBB) is instrumental in clearing toxic metabolites from the brain, such as amyloid-β (Aβ) peptides, and delivering essential nutrients to like insulin. In Alzheimer's disease (AD) increased Aβ levels are paralleled by decreased insulin levels, which accompanied signaling deficits at BBB. Thus, we investigated impact of insulin-like growth factor receptor (IGF1R IR) on trafficking Following intravenous infusion an IGF1R/IR kinase inhibitor (AG1024) wild-type mice, BBB
In this study, gemini ammonium sulfobetaine (GAS) is designed and synthesized using isophorone diisocyanate connecting the sulfobetaines (AS) to obtain a viscoelastic surfactant exhibiting better viscosification salt resistance. AS prepared monomers of erucic acid, N-dimethyl-1,3-propanediamine, 3-chloro-2-hydroxypropanesulfonic acid sodium. The properties GAS its proppant suspension as well gel-breaking mechanisms are investigated. critical micelle concentration 2.1 × 10-7 mol mL-1....
Blood-brain barrier (BBB) dysfunction is prevalent in Alzheimer’s disease and other neurological disorders. Restoring normal BBB function through RNA therapy a potential avenue for addressing cerebrovascular changes these disorders that may lead to cognitive decline. Although lipid nanoparticles have been traditionally used as drug carriers RNA, bicelles emerging better alternative because of their higher cellular uptake superior transfection capabilities. Cationic composed DPPC/DC7PC/DOTAP...
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease in clinical practice. It mainly due to cardiovascular hypoplasia during embryonic development. The study aimed find etiology TOF.Through mRNA expression profile analysis GSE35776 dataset, differentially expressed genes (DEGs) were found, and functional protein-protein interaction (PPI) network then performed on DEGs. Likewise, hub clusters DEGs analyzed using PPI network. Differentially miRNAs from GSE35490...
Abstract Background Decreased brain insulin levels exacerbate cognitive decline in AD. Insulin the is derived from systemic circulation via blood‐brain barrier (BBB). We hypothesize that type II diabetes (T2D) sequelae and Aβ peptide exposure disrupt signaling at BBB inhibit delivery to brain. Further, we propose defects contribute accumulation AD Methods The following studies were performed wild‐type (WT) mice on regular chow (RC) diet, WT high fat (HF) diet (manifest resistance), APP/PS1...
In the previous study, we identified bone morphogenetic protein 4 (BMP4) responsible for non-syndromic cleft lip with or without palate (NSCL/P). We aimed to elucidate effects and mechanisms of BMP4 on epithelial-mesenchymal transition (EMT) through Smad1 signaling pathway be involved in NSCL/P.The human oral epidermoid carcinoma cells (KBs) were transfected plasmids small interfering RNA (siRNA) build models. The migration was evaluated by transwell assay. Western blotting quantitative...