A5042221260- Agricultural and Food Sciences
- Brucella: diagnosis, epidemiology, treatment
- Escherichia coli research studies
- Growth and nutrition in plants
- Immunotherapy and Immune Responses
- Soil Management and Crop Yield
- Nitrogen and Sulfur Effects on Brassica
- Phytase and its Applications
- Peanut Plant Research Studies
- Pleural and Pulmonary Diseases
- Soybean genetics and cultivation
- Banana Cultivation and Research
- Crop Yield and Soil Fertility
- Weed Control and Herbicide Applications
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Systemic Sclerosis and Related Diseases
- Insect Resistance and Genetics
- Agroforestry and silvopastoral systems
- Cassava research and cyanide
- Plant Disease Management Techniques
- Plant Micronutrient Interactions and Effects
- Bacteriophages and microbial interactions
Aix-Marseille Université
2008-2022
Inserm
2008-2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022
Université de Montpellier
2020
Systèmes d’élevage méditerranéens et tropicaux
2020
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2020
Pontifícia Universidade Católica do Paraná
2014-2020
Pulmonary Vascular Research Institute
2016
Centre National de la Recherche Scientifique
2008-2012
Centre d’Immunologie de Marseille-Luminy
2008-2012
Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after inoculation in intestinal loops, dendritic cells from ileal Peyer's patches become infected constitute cell target this pathogen. In vitro, we found replicates hinders their functional activation. addition, identified new protein Btp1, which down-modulates maturation by interfering with TLR2 signaling pathway. These results control function,...
Bacteria of the Brucella genus are facultative intracellular class III pathogens. These bacteria able to control trafficking their vacuole, presumably by use yet unknown translocated effectors. To identify such effectors, we used a high-throughput yeast two-hybrid screen interactions between putative human phagosomal proteins and predicted spp. proteins. We identified specific interaction small GTPase Rab2 protein named RicA. This was confirmed GST-pull-down with GDP-bound form Rab2. A...
The intracellular pathogen Brucella abortus survives and replicates inside host cells within an endoplasmic reticulum (ER)-derived replicative organelle named the "Brucella-containing vacuole" (BCV). Here, we developed a subcellular fractionation method to isolate BCVs characterize for first time protein composition of its niche. After identification BCV membrane proteins by 2 dimensional (2D) gel electrophoresis mass spectrometry, focused on two eukaryotic proteins:...
Endothelial colony-forming cells (ECFC) constitute an endothelial progenitor fraction with a promising interest for the treatment of ischaemic cardiovascular diseases. As soluble CD146 (sCD146) is new factor promoting angiogenesis, we examined whether sCD146 priming could improve therapeutic potential ECFC and defined involved mechanism. We investigated effects on regenerative properties in vivo . In mouse model hindlimb ischaemia, homing radiolabelled to tissue was assessed by SPECT-CT...
// Elisa Roca 1, 2, 3 , Romaric Lacroix 4 Coralie Judicone 5 Sophie Laroumagne 2 Stéphane Robert 1 Sylvie Cointe Alexandre Muller Elise Kaspi 6, 7 Patrice Roll Alain R. Brisson 8 Claudio Tantucci Philippe Astoul 9, * Françoise Dignat-George 4, VRCM, UMR-S1076, Aix-Marseille Université, INSERM, Faculté de Pharmacie, Marseille, France Division of Thoracic Oncology, Pleural Diseases, and Interventional Pulmonology, Hôpital Nord, AP-HM, Cattedra di Malattie dell'Apparato Respiratorio, Università...
Bacterial cyclic glucans are glucose polymers that concentrate within the periplasm of alpha-proteobacteria. These molecules necessary to maintain homeostasis cell envelope by contributing osmolarity Gram negative bacteria. Here, we demonstrate Brucella β 1,2 potent activators human and mouse dendritic cells. Dendritic cells activation requires TLR4, MyD88 TRIF, but not CD14. The showed neither toxicity nor immunogenicity compared LPS triggered antigen-specific CD8+ T responses in vivo. also...
O objetivo deste trabalho foi avaliar a resposta da canola fontes e doses de nitrogênio aplicadas na semeadura. experimento conduzido em Latossolo Vermelho distroférrico típico, com textura muito argilosa. Utilizou-se delineamento experimental blocos ao acaso, arranjo fatorial 7x2, sete N superfície semeadura (0, 20, 40, 60, 80, 100 120 kg ha-1), duas (sulfato amônio ureia) quatro repetições. realizado o híbrido Hyola 61, por dois anos, foram avaliadas as seguintes variáveis: altura planta,...
Systemic sclerosis (SSc) is an autoimmune disorder characterized by excessive fibrosis, immune dysfunction, and vascular damage, in which the expression of many growth factors deregulated. CD146 was recently described as a major actor SSc. Since also exists circulating soluble form (sCD146) that acts factor numerous angiogenic- inflammation-related pathologies, we sought to identify mechanisms underlying generation sCD146 characterize regulation functions different variants identified SSc.We...
No Rio Grande do Sul são poucos os fragmentos de Floresta Ombrófila Mista em estado natural. Isso, por si só, justifica a importância estudar esses locais visando à compreensão da sua dinâmica interna e relação com o ambiente entorno. O objetivo deste trabalho foi caracterizar crescimento acúmulo biomassa um remanescente Mista, localizado na Nacional Passo Fundo (FLONA). experimento realizado no Município Mato Castelhano, RS, utilizando método área fixa. Foram instaladas 10 parcelas 30 x m...
The aim of this work was to evaluate the effect yield and morphological components maize crop according different levels defoliation in phenological stages crop. experimental design a randomized block with 7 treatments 4 replicates. were: control without (SD), removal two leaves (2L-V4) four (4L-V4) V4 stage , lower third (LT-VT), middle (MT-VT), upper (UT-VT) total (SF-VT) VT stage. Plant height spike insertion, number grains, rows, grains per one thousand grain mass were assessed. Plants...
The aim of this study was to evaluate the environmental effect different sowing times on productivity and quality hybrid canola grains Hyola 60, 61, 401 432 sown dates 05/12/08, 05/31/08, 06/21/08 08/02/08, with a test 04/18/08 61 hybrids.The experimental design consisted randomized blocks in factorial 4 x local environment characterized by air temperature, relative humidity rainfall.With these data, we computed actual (ETR) reference (ETo) evapotranspiration.The soil moisture evaluated...
En Guyane, les questions environnementales et le besoin croissant en énergie produits alimentaires liés à la croissance démographique exercent une pression accrue sur ressources naturelles par changement d’affectation des sols qu’ils engendrent. Des agriculteurs testent cependant pratiques faible impact conciliant objectifs de production respect l’environnement. Une prospection dans systèmes agricoles guyanais, basée enquêtes terrain, a permis description ces ; parmi celles-ci, dynamique du...
<b>Background:</b> Pleural biomarkers are needed for the diagnosis of malignant pleural effusion at an early stage before true carcinomatosis. Tumor cells produce microparticles, and, therefore, we hypothesized that tumor-derived microparticles could be present in liquid and help to identify patients with effusions by a non-invasive method. <b>Methods:</b> Fifty benign (n=11) or (n=39) were included this study. Among them, 39 consecutive histologically shown primary metastatic cancer...
O objetivo do presente trabalho foi avaliar a eficácia da utilização de diferentes princípios ativos no controle químico ferrugem asiática em lavouras oeste paranaense. experimento conduzido na estação experimental MBF Pesquisas Agronômicas município Maripá, período novembro 2020 abril 2021. delineamento utilizado blocos casualisados contendo 5 tratamentos com 4 repetições, os foram compostos por uma testemunha absoluta e quatro químicos ativos. As aplicações fungicida iniciaram aos 45 dias...