A5047629853- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Cellular Mechanics and Interactions
- Bacteriophages and microbial interactions
- Evolution and Genetic Dynamics
- Pluripotent Stem Cells Research
- Mathematical and Theoretical Epidemiology and Ecology Models
- Mathematical Biology Tumor Growth
- DNA and Biological Computing
- Diffusion and Search Dynamics
- Protein Structure and Dynamics
- Gene Regulatory Network Analysis
- Stochastic processes and statistical mechanics
- Elasticity and Material Modeling
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
institut Camille-Jordan
2024
Institut de Mathématiques de Toulouse
2020-2024
Université de Toulouse
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Université Toulouse III - Paul Sabatier
2020-2024
Université Claude Bernard Lyon 1
2024
Université Jean Monnet
2024
École Centrale de Lyon
2024
Institut National des Sciences Appliquées de Lyon
2024
Institut National des Sciences Appliquées de Toulouse
2022
Although cell-to-cell heterogeneity in gene and protein expression within cell populations has been widely documented, we know little about its biological functions. By studying progenitors of the posterior region bird embryos, found that levels transcription factors Sox2 Bra, respectively involved neural tube (NT) mesoderm specification, display a high degree heterogeneity. combining forced downregulation approaches with time-lapse imaging, demonstrate Sox2-to-Bra ratio guides progenitor’s...
A major challenge in biology is to understand how mechanical interactions and cellular behavior affect the shapes of tissues embryo morphology. The extension neural tube paraxial mesoderm, which form spinal cord musculoskeletal system, respectively, results elongated shape vertebrate embryonic body. Despite our understanding each these elongates independently others, morphogenetic consequences their simultaneous growth are still unclear. Our study investigates differential growth, tissue...
Abstract The study of how mechanical interactions and different cellular behaviors affect tissues embryo shaping has been remains an important challenge in biology. Axial extension is a morphogenetic process that results the acquisition elongated shape vertebrate embryonic body. Several adjacent are involved process, including form spinal cord musculoskeletal system: neural tube paraxial mesoderm, respectively. Although we have growing understanding each these elongates, still need to fully...
Understanding how individual behaviours contribute to collective actions is key in biological systems. In Myxococcus xanthus, a bacterial predator, swarming shifts rippling patterns due changes the local environment near prey colonies. Through high-resolution microscopy and theoretical analysis, we demonstrate that two properties drive this shift: cellular alignment guided by an extracellular matrix ability of cells reverse resolve congestion. A tunable refractory period reversal system...
The aim of this paper is to model the collective behavior Myxococcus xanthus bacteria better understand emerging patterns at level colony. We use image analysis and data treatment on experimental bacteria. develop two models whose main novelty polarity-based reversals. first based contact dynamics approach second one inspired by a molecular approach. compare we show numerical simulations in 2D. mathematical biological aspects each are discussed.
Abstract Although cell-to-cell heterogeneity in gene and protein expression within cell populations has been widely documented, we know little about its potential biological functions. We addressed this issue by studying progenitors that populate the posterior region of vertebrate embryos, a population known for capacity to self-renew or contribute formation neural tube paraxial mesoderm tissues. Posterior are characterized co-expression Sox2 Brachyury (Bra), two transcription factors...
We introduce two 2D mechanical models reproducing the evolution of viscous tissues in contact. Their main property is to model swirling cell motions while keeping segregated, as observed during vertebrate embryo elongation. Segregation encoded differently models: by passive or active segregation (based on a repulsion pressure). compute incompressible limits models, and obtain strictly segregated solutions. The thus obtained are compared. A striking feature persistence pressure at limit:...