A5021872239- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Lymphatic System and Diseases
- Vasculitis and related conditions
- Spondyloarthritis Studies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Nigella sativa pharmacological applications
- Pomegranate: compositions and health benefits
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Mast cells and histamine
- Peripheral Neuropathies and Disorders
- interferon and immune responses
- Chemotherapy-induced organ toxicity mitigation
- Chronic Lymphocytic Leukemia Research
- Hepatitis Viruses Studies and Epidemiology
- Gastroesophageal reflux and treatments
- Inflammatory Myopathies and Dermatomyositis
- Helicobacter pylori-related gastroenterology studies
Karadeniz Technical University
2020-2024
Ankara University
2018-2023
Center for Rheumatology
2021
Sağlık Bilimleri Üniversitesi
2021
The purpose of this study was to determine hepatitis B virus (HBV) screening rates in patients receiving anti-tumor necrosis factor (TNF)-α therapy and the frequency HBV reactivation with resolved infection (hepatitis surface antigen [HBsAg] negative, core antibody [Anti-HBc] positive).Data from 1834 who underwent anti-TNF-α Rheumatology, Gastroenterology Dermatology Departments our hospital between 2010 2020 were retrospectively analyzed. Within 6 months before initial therapy, performing a...
Background/Objective Interleukin (IL) 35 is a member of the IL-12 family. Studies show that IL-35 an important anti-inflammatory cytokine and suppresses effector T-cell activity. In this study, we aimed to evaluate serum levels in systemic sclerosis (SSc) patients its potential relation with clinical findings. Methods We conducted cross-sectional analysis 70 SSc 29 healthy volunteers single center 5 months' period. Extension skin fibrosis was evaluated by using modified Rodnan score. Disease...
The aims of this study were to compare the frequency Helicobacter pylori between patients with rheumatoid arthritis (RA) and without methotrexate (MTX)-related gastrointestinal system (GIS) intolerance, demonstrate associated factors such intolerance.The data 9756 RA who presented January 2011 December 2020 evaluated. Methotrexate-related GIS intolerance was defined as discontinuation MTX owing dyspeptic symptoms despite supportive measures detected in 1742 (31.3%) among 5572 users. A total...
Calprotectin is an inflammatory biomarker which assesses disease activity in rheumatoid arthritis (RA). The objective of this study was to test whether serum calprotectin associated with clinical and ultrasonographic patients RA, analyse its predicting value for evaluation despite normal C-Reactive protein (CRP) levels.We included 80 RA 30 healthy subjects. Patients were examined clinically by ultrasound, (US7 score) along laboratory parameters (calprotectin, CRP, erythrocyte sedimentation...
Behçet syndrome (BS) is a multisystemic chronic vasculitic disease. Among previous studies, although there are some that showed increased risk of subclinical atherosclerosis in BS, also others the opposite. The objective this study to evaluate BS by using cutoff value for intima-media thickness 2013 European Society Cardiology/European Hypertension guideline.We conducted cross-sectional analysis 100 patients and 30 healthy volunteers at single center 4-month period. All ultrasound scans were...
Familial mediterranean fever (FMF) is a genetic autoinflammatory disease typically diagnosed in childhood. In this study, we aimed to investigate the demographic, clinical, and characteristics of patients aged 18 years older who were with FMF. Patients FMF between 2014 2022 at Karadeniz Technical University Faculty Medicine Hospital included study. divided into 2 groups based on age onset. Group I adult-onset (ages 18-40), while group II comprised late onset 40 above). Subsequently,...
Purpose: Rosmarinic acid (RA) is a natural phenolic compound with antioxidant and anti-inflammatory effects. Quercetin (QCT) powerful that prevents oxidative damage cell death by clearing oxygen radicals. It also has In this study, it was aimed to compare the effects of RA QCT against liver small bowel may occur due methotrexate (MTX) use. Materials Methods: The study conducted on model MTX-induced intestine in 40 Spraque Dawley male rats. were administered separately combination...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease usually involving small vessels and progressing with necrotizing inflammation. Treatment requires long-term use of immunosuppressive agents to inhibit activity. Serious infections (SIs) are common complication in AAV.The aim this study was identify the risk factors for serious which required hospitalization patients AAV.In retrospective cohort study., we included 84 admitted Ankara University...
Background/aim: High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as proinflammatory molecule. The serum HMGB- levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, Behcet's disease (BD) patients and healthy controls (HC) studied. Also, its association with activity scores clinical findings evaluated. Materials methods: Ninety BD 50 age-sex matched HC included the study. Disease assessed by Behcet Current Activity Form (BDCAF) Syndrome...
<h3>Background</h3> β−2 microglobulin (β2MG) is produced and secreted from T B lymphocytes. In autoimmune diseases, due to lymphocyte activation proliferation, serum β2MG level expected be higher than normal. a few studies, increased synovial fluid levels in rheumatoid arthritis (RA) were reported. <h3>Objectives</h3> The aim of this study was evaluate the concentration peripheral blood RA patients show its relationship with disease activity. <h3>Methods</h3> study, 121 50 sex age matched...
<h3>Background:</h3> Scleroderma is a connective tissue disease that characterized by fibrosis of the skin.The modified Rodnan Skin Score (mRSS) measure generally used to assess skin thickness in patients with scleroderma.Data on effectiveness mRSS training courses differ literature. <h3>Objectives:</h3> The objective our study was evaluate course rheumatology fellows departments. <h3>Methods:</h3> included 6 from departments rheumatology.Participants were given 1-hour-long theoretical...
Abstract Background Beta-2 microglobulin (β2M) is mainly released from activated lymphocytes. Increased serum β2M levels have been shown in autoimmune diseases. The aim of this study was to analyse the rheumatoid arthritis (RA) patients and evaluate its relationship with disease activity measures. Material Methods This cross-sectional included 137 RA patients, 102 ankylosing spondylitis (AS) 50 healthy controls (HC). To assess 28-joint Disease Activity Score-Erythrocyte Sedimentation Rate...
<h3>Background</h3> Familial Mediterranean Fever (FMF) is an autosomal recessive inherited autoinflammatory disease characterised with unpredictable attacks of fever, polyserositis and arthritis. The associated MEFV gene mutation causing dysfunction pyrin protein. This related abberant production proinflammatory cytokines, especially IL-1β IL-18. IL-33 a novel cytokine that belongs to interleukin (IL)−1 superfamily. When released from epithelial, endothelial fibroblasts, it binds its...
<h3>Background</h3> Interleukin (IL)−35 is a member of the IL-12 family. Studies show that IL-35 an important anti-inflammatory cytokine and suppresses effector T cell activity. Systemic sclerosis (SSc) chronic disease characterised by vascular damage, autoimmunity fibrosis. <h3>Objectives</h3> In this study, we aimed to evaluate serum level in SSc patients its potential relation with findings. <h3>Methods</h3> Fifty-five 25 healthy controls were included study. All diagnosed according 2013...
<h3>Background</h3> Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), eosinophil-to-lymphocyte (ELR), basophil-to-lymphocyte (BLR), and mean platelet volume (MPV) may potentially reflect inflammatory status in systemic autoimmune diseases. <h3>Objectives</h3> The aim of this study is to investigate the association NLR, MLR, ELR, BLR MPV with disease manifestations, activity severity patients sclerosis (SSc). <h3>Methods</h3> 59 SSc 50 healthy controls were included study....
Amaç: Skleroderma/Sistemik skleroz (SSk), fibrozis ile karakterize olan otoimmün bir bağ doku hastalığıdır.SSk ilişkili interstisyel akciğer hastalığı (SSk-İAH) önemli mortalite ve morbidite nedenlerinden birisidir.Prokalsitonin (PCT) bakteriyel enfeksiyonlar sepsisin tanısında takibinde kullanılan belirteçtir.Bakteriyel pnömoni hastalıklarının ayırıcı yer tutmaktadır.Bu çalışmada SSk-İAH hastalarının serum PCT
Objectives: Interleukin-33 (IL-33) is a novel cytokine which belongs to IL-1 superfamily.It shares structural homology and common signaling pathway with IL-1β whose excessive secretion results in Familial Mediterranean Fever (FMF).In this study, we aimed evaluate the serum IL-33 its decoy receptor sST2 levels patients FMF correlation disease activity. Materials Methods:In cross-sectional single-centered 76 30 age-and sex-matched healthy individuals were recruited.Disease activity was...
Amaç: Psöriatik artrit (PsA