A5055435558- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Ocular Diseases and Behçet’s Syndrome
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Tuberculosis Research and Epidemiology
- Inflammatory Myopathies and Dermatomyositis
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- interferon and immune responses
- Dermatological and COVID-19 studies
- Kawasaki Disease and Coronary Complications
- Cardiovascular Issues in Pregnancy
- Antibiotic Use and Resistance
- Paraoxonase enzyme and polymorphisms
- Social Media in Health Education
- Biosimilars and Bioanalytical Methods
- Pregnancy and Medication Impact
- IgG4-Related and Inflammatory Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Dokuz Eylül University
2018-2025
Izmir Kâtip Çelebi University
2024
İzmir University of Economics
2023-2024
Kastamonu University
2021-2023
Aims: We aimed to evaluate the effect of comorbidities on first tumor necrosis factor inhibitor (TNFi) treatment response and retention in patients with rheumatoid arthritis (RA). Methods: The study included adult RA (with M05 M06 ICD codes) registered TURKBIO database receiving their TNFi treatment. Data demographic, clinical, laboratory features, disease activity scores, other follow-up parameters (at beginning months 6 12) were collected. Log-Rank test Kaplan-Meier curve used determine...
Abstract Clinical data on the use of tumour necrosis factor inhibitors (TNFi) in late-onset ankylosing spondylitis (LoAS) are limited. The present study aimed to evaluate efficacy, safety, and treatment adherence associated with initial TNFi therapy biologic naive patients diagnosed LoAS. Patients whose age onset was ≥ 45 years < were classified as having LoAS YoAS, respectively, based symptom onset. There 2573 YoAS 281 Baseline disease activity measures similar between groups. No...
Metabolic syndrome (MetS) is one of the preventable risk factors for cardiovascular disease (CVD). The aim this study was to investigate effect MetS on CVD and cumulative organ damage in a multi-center, large cohort patients with Takayasu arteritis (TAK).This cross-sectional involving 192 consecutive TAK from seven tertiary rheumatology centers Turkey. Clinical data fulfilling 1990 American College Rheumatology classification criteria were collected medical records. They evaluated CVD,...
This study aimed to examine fetomaternal outcomes in pregnant women a large Turkish Takayasu arteritis (TAK) cohort and evaluate the effects of pregnancy on disease those patients.This is involving 296 pregnancies 112 TAK patients from 8 tertiary rheumatology centers Turkey. Pregnancies were divided into 2 groups as pre-d (before onset) post-d (after onset). In addition, further subgroups according complications (FMC) development status. Finally, grouped with without history after onset.In...
Behçet's disease is a systemic vasculitis affecting both arteries and veins, as well caus- ing recurrent inflammatory multiorgan disease. Vascular involvement associated with increased mortality morbidity. Matrix metalloproteinases are released at sites of inflammation degrade various components the extracellular matrix. Increased levels metalloproteinase-9 metal- loproteinase-2 have been previously reported in disease.In this cross-sectional study, metalloproteinase-2 metalloproteinase-3...
<h3>Background:</h3> Although biological therapies are frequently used in rheumatology practice, some potential side effects increase anxiety levels patients. Information from various sources may positively or negatively affect this level of and the decision to approve drug [1]. <h3>Objectives:</h3> In our study, we aimed determine effect information about therapy on patients' treatment decisions levels; expectations regard. <h3>Methods:</h3> 91 patients aged 18-65 years using for rheumatic...
We aimed to investigate the effects of coronavirus disease 2019 (COVID-19) pandemic on course and treatment patients with inflammatory rheumatic musculoskeletal (iRMD) using biologic or targeted synthetic modifying drugs (b/tsDMARDs).The study was carried out in two stages: first stage we investigated delay b/tsDMARD 3 months pandemic; second stage, all who decided continue after interruption 12-month period.A total 521 were included study. The iRMD diagnosis listed as spondyloarthritis...
<h3>Background</h3> The first symptoms of ankylosing spondylitis (AS) patients usually begin prior to 45 years, but can occur later in life. <h3>Objectives</h3> purpose this study is evaluate the efficacy and safety anti-TNFα treatment late-onset AS (LoAS) comparison those with adult onset (AoAS). <h3>Methods</h3> We studied TURKBIO registry between dates January 2011 November 2018. All fulfilled modified New York criteria for <sup>1</sup> were classified into 2 groups based on their age at...
A 56-year-old man presented with a 3-month history of cough, chest pain and dyspnea. He denied having fever, sputum or haemoptysis. His medical was unremarkable he never smoked. Cardiac examination normal, radiography showed bilateral opacity in the upper zones (Fig.1a). CT lungs revealed apical fibrosis honeycomb appearance (Fig.1b). Laboratory test results, which included complete blood count, biochemical tests, assays acute phase reactants angiotensin-converting enzyme, were within normal...
<h3>Background</h3> IgG4-related disease is a recently recognised inflammatory of unkown etiology, often seen in men over the age 50 and may affect many organs systems with elevated serum IgG4 levels typical histopathological features. <h3>Objectives</h3> The aim this study to determine demographic clinical characteristics patients disease. <h3>Methods</h3> Patients diagnosed as having Ig-G4-related by their findings imaging features and/or increased concentrations (> 135 mg/dl) from two...
<h3>Background:</h3> Scleroderma is a connective tissue disease that characterized by fibrosis of the skin.The modified Rodnan Skin Score (mRSS) measure generally used to assess skin thickness in patients with scleroderma.Data on effectiveness mRSS training courses differ literature. <h3>Objectives:</h3> The objective our study was evaluate course rheumatology fellows departments. <h3>Methods:</h3> included 6 from departments rheumatology.Participants were given 1-hour-long theoretical...
Background: Limited joint mobility (LJM) is a musculoskeletal disorder caused by flexion contractures of hand common complication in systemic sclerosis (SSc) patients. The distal parts the upper limb (hands and fingers) most involved site SSc. Objectives: In this study, we aimed to evaluate LJM SSc patients determine relationship between clinical features disease. Methods: A total 113 (>18 years old) diagnosed with diffuse cutaneous (DcSSc) limited (LcSSc) 104 healthy controls were...
<h3>Background</h3> Enthesitis in patients with psoriatic arthritis (PsA) can be a therapeutic challenge. <h3>Objectives</h3> To explore the impact of tumor necrosis factor inhibitors (TNFi) on enthesitis PsA EuroSpA collaboration network <sup>[1]</sup>. <h3>Methods</h3> Prospectively collected data from biologic-naïve ≥18 years at diagnosis, who initiated TNFi between 2010-2020 and had available baseline (defined as tenderness any enthesis included Maastricht Ankylosing Spondylitis Score...
Primary Sjogren's Syndrome(pSS) is a chronic autoimmune disease and focal lymphocytic infiltration of the exocrine glands key pathological feature (1). Polycythemia vera(PV) myeloproliferative disorder characterized by JAK-2 mutations increased red blood cell mass(2,3). Autoimmune diseases hematological malignancies can often be observed together. Patients with SS are at higher risk developing lymphoproliferative mainly low-grade B-cell lymphomas predominantly marginal zone lymphoma....
<h3>Background</h3> Biosimilar infliximab (CT-P13) has been used to treat patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic (PsA) in Turkey since 2013. <h3>Objectives</h3> The aim of this study was examine its efficacy, drug survival compare it the original reference (inf) inflammatory rheumatic diseases based on database from TURKBIO registry. <h3>Methods</h3> All RA, SpA, PsA, other receiving CT-P13 inf registered between dates <sup>June 2013</sup> January...
Ö Z Amaç: D vitamini eksikliği lipid metabolizması üzerine olumsuz etki oluşturmakta ve kardiyovasküler riski artırmaktadır.Paraoksonaz-1 (PON1) enzim aktivitesi, yüksek dansiteli lipoprotein (HDL) aktivitesini belirleyen faktörlerden birisidir.Bu araştırmada, vitamin düzeyi ile PON1 aktivitesi arasında ilişkili olup olmadığının incelenmesi
Background: The frequency of comorbidities has increased in spondyloarthritis patients compared to the general population. effect on tumour necrosis factor alpha inhibitor (TNFi) drug retention and treatment response not been well evaluated. Objectives: purpose this study assess impact first TNFi survival with axial (axSpA) registered TURKBIO database. Methods: In study, comorbidities, disease activity scores at baseline month 6 were recorded AxSpA iniating between 2011 2019. Kaplan Meier...
Background: Axial spondyloarthritis (axSpA) is a chronic, inflammatory disease that primarily affects the axial skeleton. Secukinumab human monoclonal antibody binds to protein interleukin (IL)-17A. Although some studies showed obesity had negative effect on efficacy of tumor necrosis factor alpha inhibitor (TNFα -i) treatment in AS patients (1), no data available for secukinumab. Objectives: To evaluate response and drug survival secukinumab with axSpA. Methods: We performed an...
Background: Vogt-Koyanagi-Harada Disease (VKHD) is a systemic autoimmune disease characterized by bilateral granulomatous panuveitis associated with symptoms, including neurological, dermatological and audiovestibular systems. Due to its nature, it may accompany other conditions. However, there considerably limited number of reports on the association VKHD rheumatologic diseases. Objectives: To investigate relationship between inflammatory rheumatological Methods: Patients who had uveitis...
Background: Currently, biologic treatments are used effectively in patients with psoriatic arthritis (PsA). Objectives: The aim of this study was to evaluate and compare long-term drug survival the first including adalimumab, certolizumab, etanercept, golimumab, infliximab, secukinumab ustekinumab PsA. Methods: PsA patients, electronically registered at each visit TURKBIO database between 2011 2019 were included study. PASW 18.0 for Windows statistical analysis. Drug rates calculated by...
Background: Studies indicate that patients with rheumatoid arthritis (RA) are at increased risk of developing several comorbid disorders. Comorbidities affect treatment decisions, the effectiveness treatment, quality life, RA prognosis, and survival rate [1]. Objectives: The aim this study to investigate impact comorbidity on first TNF inhibitor persistence in RA. Methods: In TURKBIO database, an ICD 10-diagnosis (M05 or M06) who started therapy between January 2011 June 2019 were enrolled....