A5052201729- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Dermatological and COVID-19 studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Lysosomal Storage Disorders Research
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Metabolism and Genetic Disorders
- Carbohydrate Chemistry and Synthesis
- Immunodeficiency and Autoimmune Disorders
- Ocular Diseases and Behçet’s Syndrome
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Bone and Joint Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- interferon and immune responses
- Spine and Intervertebral Disc Pathology
- Trypanosoma species research and implications
- Autoimmune Bullous Skin Diseases
Dokuz Eylül University
2019-2025
Izmir University
2024-2025
Izmir Bozyaka Eğitim ve Araştırma Hastanesi
2023-2024
Center for Rheumatology
2022
Istanbul University
2016-2019
Abstract Clinical data on the use of tumour necrosis factor inhibitors (TNFi) in late-onset ankylosing spondylitis (LoAS) are limited. The present study aimed to evaluate efficacy, safety, and treatment adherence associated with initial TNFi therapy biologic naive patients diagnosed LoAS. Patients whose age onset was ≥ 45 years < were classified as having LoAS YoAS, respectively, based symptom onset. There 2573 YoAS 281 Baseline disease activity measures similar between groups. No...
Objectives: Systemic sclerosis (SSc) patients exhibit a heightened vulnerability to sarcopenia, condition characterized by the loss of muscle mass and strength. This study aims determine prevalence sarcopenia in with SSc investigate associated factors contributing this condition. Methods: Eighty were included study, their demographic clinical characteristics, body composition bioelectrical impedance analysis, SARC-F score, chair-stand test performance, 4 m walking speed recorded. Results:...
Aims: We aimed to evaluate the effect of comorbidities on first tumor necrosis factor inhibitor (TNFi) treatment response and retention in patients with rheumatoid arthritis (RA). Methods: The study included adult RA (with M05 M06 ICD codes) registered TURKBIO database receiving their TNFi treatment. Data demographic, clinical, laboratory features, disease activity scores, other follow-up parameters (at beginning months 6 12) were collected. Log-Rank test Kaplan-Meier curve used determine...
The course of novel coronavirus disease 2019 (COVID-19) has been special concern in patients with inflammatory rheumatic diseases (IRDs) due to the immune dysregulation that may be associated these and medications used for IRDs, affect innate responses.In this cohort study, we aimed report characteristics variables COVID-19 outcome among Turkish IRDs.Between April June, 2020, 167 adult IRD were registered from 31 centers 14 cities Turkey. Disease was classified 4 categories; (i) outpatient...
The aim of this study was to evaluate the impact obesity on treatment response secukinumab and drug survival rate in patients with ankylosing spondylitis (AS).
ABSTRACT Objectives To evaluate the impact of familial Mediterranean fever (FMF) features on clinical course and outcomes coronavirus disease 2019 (COVID-19) FMF after COVID-19. Methods Consecutive patients with COVID-19 were enrolled from three referral hospitals. Clinical detailed information obtained patient interviews medical records. Results Seventy-three included in study. 94.5% had symptoms We found 24.7% hospitalization, 12.3% respiratory support, 4.1% intensive care unit admission,...
Vasculitis may rarely be seen in the course of myeloproliferative neoplasms (MPN). In vasculitis associated with hematological diseases, mostly small- and medium-vessel involvement is expected, aortitis very rare. It not exactly known whether large-vessel MPN a paraneoplastic phenomenon or coincidental. We aimed to present an uncommon case diagnosed chronic myeloid leukemia Takayasu arteritis concurrently.
<h3>Background:</h3> The present study is centered on the retrospective analysis of spondyloarthritis (SpA) patients who underwent abdominal computed tomography (CT) scans for various reasons, including malignancy screening, acute abdomen suspicion, or nephrolithiasis diagnosis. It noteworthy that in some cases, radiologists may not provide a comprehensive report structural alterations SIJ while conducting CT SpA patients. <h3>Objectives:</h3> Our primary objective to scrutinize these...
Uveitis may occur in the course of systemic inflammatory rheumatic diseases (IRD), or it be first clinical manifestation these diseases. The aim this study was to determine incidence IRD patients whose initial non-infectious uveitis.
Abstract Background: It is imperative to closely monitor patients for adverse effects of immunosuppressive (IS) agents, widely used in treating glomerulonephritis (GN). Our study aimed investigate the occurrence any drug-related events with primary GN, explicitly focusing on IS. Methods: The present analyzed 162 adult GN treated IS drugs. scrutinized demographic and clinical profiles patients, laboratory findings, side associated We further investigated frequency nature infections,...
Over the years, there has been a change in profile of patients with chronic hepatitis C (CHC). In recent more CHC have presented to clinics at cirrhotic stage, decompensated liver disease, and hepatocellular carcinoma. The aim this study was investigate changing epidemiological, clinical, virological characteristics patients.A total 313 were included study. classified into group 1 (1996-2001) 2 (2011-2016). Epidemiological, differences investigated between two periods.Overall, 44.7% (n =...
An 18-year-old man presented with generalized body ache, muscle cramps, weight loss, and painful twitching in his lower extremities.His symptoms aggravated physical exertion.There was an increased sweating on limbs trunk.His medical history notable for lichen planus.He a nonsmoker did not use illicit drugs.Family insignificant.On examination, fasciculations extremities were observed (Video 1).Consciousness, mental state, tone, power, reflexes, senses, cerebellar signs, cranial nerves...
Vedolizumab is a novel anti-inflammatory molecule that currently being used in the treatment of refractory inflammatory bowel disease. The mode action inhibiting binding activated T lymphocytes to adhesion 1 intestinal mucosal cells. Due its local effect, systemic immunosuppression not expected, and this may have negative effect on extra-intestinal symptoms disease, particularly spondyloarthritis. Currently, there limited data regarding vedolizumab spondyloarthritis symptoms. We aimed...
We aimed to investigate the effects of coronavirus disease 2019 (COVID-19) pandemic on course and treatment patients with inflammatory rheumatic musculoskeletal (iRMD) using biologic or targeted synthetic modifying drugs (b/tsDMARDs).The study was carried out in two stages: first stage we investigated delay b/tsDMARD 3 months pandemic; second stage, all who decided continue after interruption 12-month period.A total 521 were included study. The iRMD diagnosis listed as spondyloarthritis...
Ochronotic arthropathy (OcA) refers to excessive homogentisic acid (HGA) deposition in the musculoskeletal system. Our current understanding of OcA is limited, as there are less than a thousand alkaptonuria (AKU) cases reported literature. Herein, we investigated rheumatological manifestations group adult AKU patients.Adult patients with symptoms suggestive were included. Patients underwent detailed assessment. Laboratory testing, including autoantibodies and radiological investigations such...
Patients with inflammatory rheumatic diseases faced several challenges during the COVID-19 pandemic. Uncertainties such as lack of evidence regarding use immunosuppressive (IS) therapies and deferred patient care because limited health resources affected negatively on many aspects treatment decisions routine follow-up patients. In this study, we aimed to investigate prevalence severity SARS-CoV-2 infection, impact pandemic delays in clinical follow-up, changes IS treatment, vaccination...