A5048659524- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- SARS-CoV-2 and COVID-19 Research
- Dermatologic Treatments and Research
- Dermatological and COVID-19 studies
- Atherosclerosis and Cardiovascular Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intestinal and Peritoneal Adhesions
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Muscle and Compartmental Disorders
- Psychosomatic Disorders and Their Treatments
- Genital Health and Disease
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Biosimilars and Bioanalytical Methods
- Lymphadenopathy Diagnosis and Analysis
- Pregnancy and Medication Impact
- Psoriasis: Treatment and Pathogenesis
Ümraniye Eğitim ve Araştırma Hastanesi
2016-2023
University of Health Sciences
2022-2023
Sağlık Bilimleri Üniversitesi
2017-2022
Istanbul University
2010-2022
University of Health Science
2022
Center for Rheumatology
2014-2016
Yıldız Technical University
2014
Fatih University
2014
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2008
Associations between autoantibodies and clinical features have been described in systemic lupus erythematosus (SLE). Herein, we aimed to define autoantibody clusters their correlations a large cohort of patients with SLE.We analyzed 852 SLE who attended our clinic. Seven were selected for cluster analysis: anti-DNA, anti-Sm, anti-RNP, anticardiolipin (aCL) immunoglobulin (Ig)G or IgM, anticoagulant (LAC), anti-Ro, anti-La. Two-step clustering Kaplan-Meier survival analyses used.Five...
Patients with systemic lupus erythematosus (SLE) have increased rates of cardiovascular disease (CVD) that are one the major causes mortality. The aim this study was to determine frequencies metabolic syndrome (MetS) and CVD in SLE patients investigate link between these clinical features SLE.A total 311 were consecutively assessed for cumulative organ damage (SDI/SLICC scores), history MetS as defined by National Cholesterol Educational Program Adult Treatment Panel III (NCEP ATP III)....
The course of novel coronavirus disease 2019 (COVID-19) has been special concern in patients with inflammatory rheumatic diseases (IRDs) due to the immune dysregulation that may be associated these and medications used for IRDs, affect innate responses.In this cohort study, we aimed report characteristics variables COVID-19 outcome among Turkish IRDs.Between April June, 2020, 167 adult IRD were registered from 31 centers 14 cities Turkey. Disease was classified 4 categories; (i) outpatient...
Aim To assess subclinical atherosclerosis and the role of inflammatory mediators, vascular endothelial cell activation markers adipocytokines in systemic lupus erythematosus (SLE) presence or absence metabolic syndrome (MetS). Methods We studied 66 premenopausal female SLE patients (20 with MetS) 28 healthy controls (HCs) without history cardiovascular disease (CVD). Subclinical was screened by measuring carotid intima media thickness (CIMT). Serum levels high sensitivity C-reactive protein...
Abstract Physicians are challenged by the recognition and treatment of older patients with rheumatoid arthritis (RA). The aim this case-control study was to evaluate retention safety conventional disease-modifying anti-rheumatic drugs in RA. In observational study, we assessed RA (≥65 years) who were diagnosed 3 different rheumatology centers from Turkey. Patients divided as those aged ≥65 years (elderly [ERA]) <65 (young [YRA]) at time DMARD initiation. Mann-Whitney U test used for...
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory of unknown etiology and pathogenesis, which can affect all organs. The most commonly involved organs are the pancreas, hepatobiliary system, salivary glands, orbits lymph nodes. Rarely, thyroid, pituitary, aorta, lung kidney may also be involved; mesenteric involvement rare. association IgG4-RD with some rheumatological diseases observed; while there data in literature about rheumatoid arthritis Sjögren syndrome, but...
This study aimed to investigate the prevalence of malnutrition according Global Leadership Initiative on Malnutrition (GLIM) criteria in community-dwelling older adults Turkey.Malnutrition was assessed based GLIM criteria, and Mini-Nutritional Assessment-Short Form used for screening. The severity determined as severe or moderate phenotypic GLIM.Five hundred sixty-nine (69% female, mean age 74.42±6.58 years) participated this study. educational statuses participants were follows: 17.2%,...
Patients being treated with anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents were reported to have better prognosis related COVID-19. We evaluated the factors affecting frequency, clinical course, and outcome of COVID-19 in patients anti-TNF-alpha agents.Patients rheumatoid diseases chronic inflammatory bowel retrospectively. The laboratory data routine visits, frequency COVID-19, pneumonia, hospitalization and/or intensive care unit (ICU) follow-up and, mortality recorded....
Rheumatoid arthritis (RA) prevalence increases with age and old people are special patient population. The recognition of functional disability related to RA could be challenging in elderly patients because aging itself potential co-morbid disease may also cause disability. In this study, we aimed look at the correlation between activity patients. Elderly patients, ≥65 years their routine visits were included study. composite 'disease score' 28 joints (DAS-28) was used determine groups....
Monocytes play a central role in Covid-19 infection. Monocytopenia is especially observed patients with severe In our study, we aimed to investigate the effects of monocytopenia on survival presenting suspicion Covid-19.Patients diagnosed who received inpatient or outpatient treatment pandemic clinic Umraniye Training and Research Hospital between April 2020 July were included retrospective cohort study. Patients divided into two groups, non-severe. Demographic data, laboratory parameters,...
Aim: Alexithymia is a disorder associated with difficulty in recognizing and expressing feelings, which can lead to an increased susceptibility disease development that makes alexithymia possible risk factor for chronic kidney (CKD). This study was performed evaluate pre-dialysis CKD end-stage renal patients undergoing hemodialysis.Material Method: The conducted the Nephrology Outpatient Department Hemodialysis unit of Ümraniye Research Training Hospital. had have diagnosis CKD. Demographic...
Anti-cytokine treatments are used in the treatment of severe COVID-19. Other studies have shown statistical significance with TNF inhibitors but not other biological/targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARD).Compare rate acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection and course incidence COVID-19 patients who received b/tsDMARD control patients.Analytical cross-sectional SETTINGS: Tertiary care hospital PATIENTS AND METHODS: All applied to...
Abstract Background: There are few data on disease characteristics and outcome of coronavirus 2019 (COVID-19) among patients with inflammatory rheumatic diseases (IRDs). In this cohort study, we aimed to report the variables associated COVID-19 IRDs. Methods: Between April June, 2020, 167 adult IRD were registered from 31 centers in 14 cities Turkey. Disease was classified 4 categories; (i) outpatient management, (ii) hospitalization without oxygen requirement, (iii) (iv) intensive care unit...
The present study aims to assess the short- and long-term effects of tofacitinib (TOFA) therapy on efficacy, safety, drug retention rate patients with rheumatoid arthritis (RA) refractory conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and/or biological (bDMARDs).Thirty-five RA who received TOFA for at least 3 months in rheumatology outpatient clinic between December 2015 2020 were included study. prospectively follow-up results obtained 6th month 5th year are...
Background/Aim: Patients with rheumatic disease are at high risk of infection complications, and vaccines essential to prevent these diseases. Moreover, biologic disease-modifying/targeted synthetic anti-rheumatic drugs (b/tsDMARDs) have been shown reduce the immunogenicity vaccines, although their effectiveness, side effects, effects on activity not yet clear. In this study, we aimed investigate incidence post-vaccine exacerbation, COVID-19 despite vaccination in patients inflammatory...
In patients with coronavirus disease 2019 (COVID-19), acute kidney injury (AKI) may alter the clinical course and outcome of disease. this study, association AKI renin angiotensin system (RAS) inhibitor treatment its consequences were examined in COVID-19 admitted to our hospital during initial stages pandemic.A total 407 between 18 85 years age (202 male 205 female) Umraniye Research And Training Hospital May 2020 August a diagnosis included study. Patients categorized as follows: Group 1,...
symptom but this was similarly reported in both patient groups (15/24 vs 29/42), as were buttock (7/24 9/42), neck (9/24 11/42), knee (5/ 24 8/42), shoulder (5/24 and foot (6/24 7/42) pain. Crucially, eye inflammation (later diagnosed uveitis) a first for 39% (9/24) of uveitis patients. Importantly, hip pain (10/24 10/42; P<0.025) significantly more frequent, whereas headache (2/24 8/42; less, Conclusion: Our study suggests that HLA-B27 positive SpA patients with are typically younger at...
<h3>Background</h3> Rheumatoid arthritis (RA)9s prevalence increases with age. The average life expectancy is getting longer and global population becoming older. Physicians will be challenged the recognition treatment of RA patients who may have different physical conditions, comorbid diseases using multi-drugs. <h3>Objectives</h3> aim this study was to evaluate clinical characteristics modalities in elderly patients. <h3>Methods</h3> We assessed (≥65 years) diagnosed according 2010...
<h3>Background</h3> Antiphospholipid syndrome (APS) is an autoimmune disease characterized mainly by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid (aPL) antibodies. Significant mortality and has been reported patients with APS. <h3>Objectives</h3> To characterize a single center cohort APS (including non-criteria manifestations) to assess their survival rates, causes associations characteristics. <h3>Methods</h3> Records 240 were studied. Demographic...