A5076273011- Industrial Gas Emission Control
- Drug Solubulity and Delivery Systems
- Pharmacological Effects of Natural Compounds
- Catalytic C–H Functionalization Methods
- Inflammatory Bowel Disease
- Fluorine in Organic Chemistry
- Gas Sensing Nanomaterials and Sensors
- Andrographolide Research and Applications
- Sulfur-Based Synthesis Techniques
- Carbon Dioxide Capture Technologies
- Pharmaceutical Economics and Policy
- Electrochemical Analysis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Abdominal Surgery and Complications
- Rheumatoid Arthritis Research and Therapies
- Environmental remediation with nanomaterials
- Inorganic Fluorides and Related Compounds
- Medicinal Plants and Bioactive Compounds
- Biochemical Acid Research Studies
- Asymmetric Hydrogenation and Catalysis
- Curcumin's Biomedical Applications
- Electrochemical sensors and biosensors
- Gastrointestinal motility and disorders
- Mycobacterium research and diagnosis
- Pharmacovigilance and Adverse Drug Reactions
Sichuan Normal University
2018-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
University of Macau
2009-2022
Hunan University of Science and Technology
2015
WuFeng University
2003
Herein, we introduce a nickel-photocatalyzed cross-coupling reaction between enol silyl ethers and CF3-substituted alkyl bromides. This method provides streamlined approach for synthesizing wide array of structurally diverse β-CF3-substituted ketones, achieving favorable yields under mild conditions. The practicality this methodology is further underscored by its successful application in the late-stage functionalization various pharmaceuticals natural products.
A novel Ru-catalyzed radical-triggered trifunctionalization of hexenenitriles is presented, employing a strategy remote cyano group migration and meta-C(sp2)-H functionalization. Through migration, the alkenyl moiety undergoes difunctionalization to formation benzylic radical intermediate. This intermediate facilitates para-selective C-H bond addition relative C-Ru within Ru(III) complex, ultimately enabling trifunctionalization. methodology provides an efficient route diverse array...
Pyridines and cyclopropanes are important structural units in chemistry. Herein, we introduce a photoredox-catalyzed approach for the ring opening 1,3-oxypyridylation of aryl using 4-cyanopyridines carboxylic acids. This sequential process involves single-electron oxidation cyclopropane, leading to nucleophilic radical pyridylation at benzylic position. The redox-neutral reaction exhibits high regioselectivity under mild conditions, offering broad substrate scope wide applicability.
Selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed agents to treat depression. Considering growth in antidepressant prescription rates, SSRI-induced adverse events (AEs) need be comprehensively clarified.
<b>Background: </b>Ulcerative colitis (UC) is an immune-mediated inflammatory disease that can lead to persistent damage and even cancer without any intervention. Conventional treatments alleviate UC symptoms but are costly cause various side effects. Tauroursodeoxycholic acid (TUDCA), a secondary bile derivative, possesses anti-inflammatory cytoprotective properties for diseases, its potential therapeutic benefits in have not been fully explored. <b>Methods: </b>Mice were subjected...
Fluorinated motifs are commonly found in drugs and agrochemicals. The inclusion of fluorine‐containing drug candidates during lead optimization has become a valuable strategy pharmaceutical research development. Significant efforts have been dedicated to synthesizing molecules with trifluoromethyl (CF3−) group on stereogenic carbon. Herein, we disclose mild efficient nickel‐catalyzed reductive cross‐coupling between α‐trifluoromethyl alkyl bromides allylic sulfones, enabling the synthesis...
Tumor necrosis factor-α inhibitors (TNFis) are used for the treatment of inflammatory bowel disease (IBD). The aim this study was to evaluate association between neurological adverse events (AEs) and TNFi use.
Ustekinumab is a fully human interleukin-12/23 (p40) inhibitor used to treat immune-mediated diseases. However, the limitations of clinical trials and expanding target population necessitate an update on ustekinumab-associated adverse events (AEs). We conducted signal mining for ustekinumab-related AEs using United States Food Drug Administration Adverse Event Reporting System (FAERS).
Background: Crohn’s disease (CD) is an inflammatory bowel disease, cases of which have substantially increased in recent years. The classical formula Dajianzhong decoction (DD, Japanese: Daikenchuto) often used to treat CD, but few studies evaluated related therapeutic mechanisms. In this study, we investigated the potential targets and mechanisms DD for treating CD at molecular level through weighted gene co-expression network. Methods: main chemical components three herbs (Zanthoxylum...