A5010066144- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Axon Guidance and Neuronal Signaling
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Connective Tissue Growth Factor Research
- Cancer Cells and Metastasis
- Receptor Mechanisms and Signaling
- Erythrocyte Function and Pathophysiology
- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
- Nerve injury and regeneration
- RNA and protein synthesis mechanisms
- Biomedical Ethics and Regulation
- CAR-T cell therapy research
- Caveolin-1 and cellular processes
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Animal Genetics and Reproduction
- Cancer Research and Treatments
SUNY Upstate Medical University
2025
Kumamoto University
2018-2021
Abstract: Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to its dense stromal environment, which impedes treatment efficacy. Recent molecular and phenotypic analyses have enhanced our understanding of PDAC, driving the development targeted therapies. Emerging research highlights crucial role pancreatic tumor microbiome in PDAC initiation progression. However, specific mechanisms influencing microenvironment (TME) systemic immunity remain incompletely understood....
The lateral ventricle (LV) is flanked by the subventricular zone (SVZ), a neural stem cell (NSC) niche rich in extrinsic growth factors regulating NSC maintenance, proliferation, and neuronal differentiation. Dysregulation of SVZ causes LV expansion, condition known as hydrocephalus; however, underlying pathological mechanisms are unclear. We show that deficiency proteoglycan Tsukushi (TSK) ependymal cells at surface cerebrospinal fluid results hydrocephalus with neurodevelopmental...
Abstract Secreted proteoglycan molecule Tsukushi (TSK) regulates various developmental processes, such as early body patterning and neural plate formation by interacting with major signaling pathways like Wnt, BMP, Notch etc. In central nervous system, TSK inhibits Wnt to control chick retinal development. It also plays important roles for axon guidance anterior commissure in mouse brain. the present study, we investigated role of development proper functioning hippocampus. We found that...
Although ribosomes are generally known to be a translational machinery, some ribosomal proteins also have accessory functions involving early development and differentiation. Previously, we reported that ribosome incorporation into human dermal fibroblasts generated embryoid body-like cell clusters, altered cellular fate, differentiated cells of all 3 germ layers. However, the molecular phenomena induced by in remained unknown. Here, demonstrate breast cancer MCF7 leads ribosome-induced...
Previously we reported that, lactic acid bacteria (LAB) can induce human dermal fibroblast (HDF) cells to form multipotent cell clusters which are able transdifferentiate into three germ layer derived lineages. Later on, confirmed that ribosome is responsible for the LAB-induced transdifferentiation and ribosomes from diverse organisms mimic LAB effect on HDF cells. In our present study have shown upon incorporation of ribosomes, non-small lung cancer line A549 gastric tubular adenocarcinoma...
Abstract Specialized microenvironment, or neurogenic niche, in embryonic and postnatal mouse brain plays critical roles during neurogenesis throughout adulthood. The subventricular zone (SVZ) the dentate gyrus (DG) of hippocampus are two major niches where is directed by numerous regulatory factors. Now, we report Akhirin (AKH), a stem cell maintenance factor spinal cord, pivotal role SVZ DG. AKH showed specific distribution development niches. Loss led to abnormal ventricular DG along with...