A new series of gold(I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands have been synthesized and characterized by mass spectrometry, NMR, X-ray diffraction. The compounds tested for their antiproliferative properties in human cancer cells nontumorigenic vitro, as well toxicity healthy tissues ex vivo. bis-carbene complex [Au(caffein-2-ylidene)2][BF4] (complex 4) appeared to be selective ovarian cell lines poorly toxic organs. To gain preliminary insights into actual...

A series of bimetallic titanium−ruthenium complexes general formula [(η5-C5H5)(μ-η5:κ1-C5H4(CR2)nPR′R′′)TiCl2](η6-p-cymene)RuCl2 (n = 0, 1, 2 or 4; R H Me; R′ H, Ph, Cy; R′′ Ph Cy) have been synthesized, including two novel compounds as well cationic derivatives [(η5-C5H5)(μ-η5:κ1-C5H4(CH2)nPPh2)TiCl2] [(η6-p-cymene)RuCl](BF4) 0 2). The solid state structure these was also established by X-ray crystallography. showed a cytotoxic effect on human ovarian cancer cells and were markedly more...

An unprecedented series of titanocene–gold bi- and trimetallic complexes the general formula [[(η5-C5H5)(μ-η5:κ1-C5H4(CH2)nPPh2)TiCl2]mAuClx]q+ (n = 0, 2, or 4; m 1, x q 0 1) have been prepared characterized spectroscopically. The luminescence spectroscopy photophysics one compounds, [[(η5-C5H5)(μ-η5:κ1-C5H4PPh2)TiCl2]2Au]PF6, investigated in 2MeTHF solution solid state at 77 298 K. Evidence for interfragment interactions based on comparison electronic band positions emission lifetimes,...

A series of new heterodinuclear luminescent complexes with two different organic ligands have been synthesized and characterized. Ru(II)(polypyridine) moiety a metal-based anticancer fragment (AuCl, (p-cymene)RuCl2, (p-cymene)OsCl2, (Cp*)RhCl2, or Au-thioglucose) are the general features these complexes. All bimetallic compounds evaluated for their antiproliferative properties in vitro human cancer cell lines. Only containing an Au(I) exhibit activity range cisplatin higher. The...

Methyl abstraction from neutral [Cp2ZrMe(ERR′)] complexes 1 (E = N, P; R, R′ alkyl, aryl) with either B(C6F5)3 or [Ph3C][B(C6F5)4] results in the formation of [Cp2Zr(ERR′)][X] 2 (X– MeB(C6F5)3–, B(C6F5)4–). The X-ray structure amido [Cp2Zr(NPh2)][MeB(C6F5)3] (2d) and [Cp2Zr(NtBuAr)][B(C6F5)4] (2e′, Ar 3,5-C6H3(CH3)2) is reported, showing a sterically dependent Zr/N−π interaction. Complexes catalyze hydrogenation electron-rich olefins alkynes under mild conditions (room temperature, 1.5 bar...

Abstract Invited for the cover of this issue is group Angela Casini at Department Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute Pharmacy, The Netherlands. image shows uptake gold N‐heterocyclic (NHC) complexes, bearing a fluorescent coumarin moiety, in cancer cells resulting anticancer effects.

New (C^N) cyclometallated Au(<sc>iii</sc>) complexes with cytotoxic properties shown to be potent inhibitors of the zinc finger protein PARP-1.

A new BODIPY-phosphane was synthesized and proved to be a versatile tool for imaging organometallic complexes. It also led easy access family of theranostics, featuring gold, ruthenium osmium The compounds' cytotoxicity tested on cancer cells, their cell uptake followed by fluorescence microscopy in vitro.

Gold phosphine complexes, such as auranofin, have been recognized for decades antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or anti-HIV treatments. However, mechanisms of action remain unclear. A challenging question is whether the gold complex a prodrug that administered an inactive precursor form rather atom remains attached ligand during treatment. In this study, we present two novel which compared auranofin and phosphonium analogue. The chosen...

Enamides have first been prepared by reaction of 5-methoxy-3-chromanone and 2-tetralone with primary amides under acidic conditions. The enantioselectivities observed in the asymmetric hydrogenation these enamides using ruthenium catalysts strongly depended on both starting ketone nature amide group.

Abstract The targeting of higher‐order DNA structures has been thoroughly developed with G‐quadruplex but not other like branched (also known as junctions). Because these alternative architectures might be high biological relevance, we implemented a high‐throughput version the FRET melting assay that enabled us to map interactions candidate four different (duplex‐ and quadruplex DNA, three‐ four‐way junctions) in rapid reliable manner. We also introduce novel index, BONDS (branched...

A new family of cationic Ti complexes 4′ with a pendant phosphine general formula [CpCpPTiOAr][BPh4] (Cp = η5-C5H5; CpP η5-C5H4(CMe2)PR2) has been prepared in four steps from 6,6-dimethylfulvene. These were designed to behave as based frustrated Lewis pairs (FLPs). The key synthetic step is reduction–oxidation sequence [CpCpPTiClOAr] 3 using lithium phosphide salts the reductants and ferricinium tetraphenylborate oxidant. Four have structurally characterized by X-ray diffraction show...

Au(<sc>i</sc>)–Homobimetallic-BODIPY-based therapeutic agents displaying both antiproliferative and anti-inflammatory properties have been synthesized, characterized, tracked <italic>in vitro</italic> in the submicromolar range.

Abstract Three new gold(I)–coumarin‐based trackable therapeutic complexes and two non‐trackable analogues have been synthesised fully characterised. They all display anti‐proliferative properties on several types of cancer cell lines, including those colon, breast, prostate. Two displayed significant anti‐inflammatory effects; one pro‐inflammatory behaviour; this highlights the impact position fluorophore caffeine scaffold. Additionally, three coumarin derivatives could be visualised in...

1,4-Hydrosilylation of dienes catalyzed by late transition metals constitutes a straightforward access to allylsilanes. However, when unsymmetric are used, it generally leads mixture regioisomers (tail or head products) via Z-specific 1,4-addition. Here we describe the first catalytic anti-1,4-hydrosilylation using cheap and stable Cp2TiF2 complex as catalyst. It affords E-allylsilanes in good excellent yields with an unprecedented regio- diastereoselectivity. Dehydrogenative double...

Four new red BODIPY–gold(<sc>i</sc>) theranostic compounds were synthesized.

Abstract Neutral phosphidozirconocene complexes [Cp 2 Zr(PR )Me] (Cp=cyclopentadienyl; 1a : R=cyclohexyl (Cy); 1b R=mesityl (Mes); 1c R= t Bu) undergo insertion into the Zr−P bond by non‐enolisable carbonyl building blocks (O=CR′R′′), such as benzophenone, aldehydes, paraformaldehyde or CO , to give Zr(OCR′R′′PR ( 3 – 7 ). Depending on steric bulk around P, react with B(C 6 F 5 ) O‐bridged cationic zirconocene dimers that display typical frustrated Lewis pair (FLP)/ambiphilic ligand...

Catalytic allyltitanation reactions were accomplished from dienes and aldehydes with only 5% of titanocene complexes at the expense employing stoichiometric amounts PMHS.

Titanium complexes outshine other catalysts: have been found to catalyze 1,4-hydrophosphination of dienes, which is thought proceed through an allyl intermediate (see scheme). Unprecedented regioselectivities (1,4- vs. 1,2-) are reached by using [TiCp2(PMe3)2] or a titanocene complex bearing pendant phosphine tether as catalysts. Detailed facts importance specialist readers published "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset. They made available...

An efficient and highly convergent synthesis of the monomeric counterpart antitumor-antibiotic marine natural product marinomycin A was achieved by using optically active titanium complexes to control configuration stereogenic centers, a stereo- regioselective cross-metathesis generate (E)-configured C20−C21 double bond, Horner−Wadsworth−Emmons olefination followed Pd-catalyzed Stille cross-coupling construct tetraene moiety.

Abstract Ten metal‐based complexes and associated ligands have been synthesized characterized. One of the metal is a coumarin‐phosphine derivative, which displays tunable fluorescence properties. The quenched in case free ligand ruthenium osmium complexes, whereas it strong for gold phosphonium derivatives. These trends were rationalized by theoretical calculations, revealed non‐radiative channels involving dark state that lower energy than emissive responsible quenching fluorescence. For Ru...