A5001056234- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organometallic Complex Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- Supramolecular Chemistry and Complexes
- Ion Transport and Channel Regulation
- Nanocluster Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Selenium in Biological Systems
- Orthopaedic implants and arthroplasty
- ATP Synthase and ATPases Research
- Asymmetric Hydrogenation and Catalysis
- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- PARP inhibition in cancer therapy
- Supramolecular Self-Assembly in Materials
- Click Chemistry and Applications
- Chromium effects and bioremediation
- Enzyme function and inhibition
- RNA and protein synthesis mechanisms
- Membrane-based Ion Separation Techniques
Cardiff University
2016-2020
London Biofoundry
2020
City University of New York
2019
University of Puerto Rico at Río Piedras
2019
Brooklyn College
2019
Imperial College London
2016-2019
University of York
2017
Centre National de la Recherche Scientifique
2010-2016
Université de Bourgogne
2010-2016
Institut de Chimie
2010-2016
Abstract The current measurement techniques described in the literature for determination of carbonyl index (CI) polyolefins such as polyethylene and polypropylene were compared contrasted. These all found to be inconsistent or inaccurate not capable differentiating significant changes peak evolution throughout accelerated ageing. As a consequence these findings, methodology, specified area under band (SAUB) is presented here more accurately represent CI general means reporting. increased...
In the supramolecular chemistry field, coordination-driven self-assembly has provided basis for tremendous growth across many subdisciplines, spanning from fundamental investigations regarding design and synthesis of new architectures to defining different practical applications. Within this framework, coordination complexes (SCCs), defined as large chemical entities formed smaller precursor building blocks ionic metal nodes organic multidentate ligands, resulting in intricate well-defined...
A series of bimetallic titanium−ruthenium complexes general formula [(η5-C5H5)(μ-η5:κ1-C5H4(CR2)nPR′R′′)TiCl2](η6-p-cymene)RuCl2 (n = 0, 1, 2 or 4; R H Me; R′ H, Ph, Cy; R′′ Ph Cy) have been synthesized, including two novel compounds as well cationic derivatives [(η5-C5H5)(μ-η5:κ1-C5H4(CH2)nPPh2)TiCl2] [(η6-p-cymene)RuCl](BF4) 0 2). The solid state structure these was also established by X-ray crystallography. showed a cytotoxic effect on human ovarian cancer cells and were markedly more...
An unprecedented series of titanocene–gold bi- and trimetallic complexes the general formula [[(η5-C5H5)(μ-η5:κ1-C5H4(CH2)nPPh2)TiCl2]mAuClx]q+ (n = 0, 2, or 4; m 1, x q 0 1) have been prepared characterized spectroscopically. The luminescence spectroscopy photophysics one compounds, [[(η5-C5H5)(μ-η5:κ1-C5H4PPh2)TiCl2]2Au]PF6, investigated in 2MeTHF solution solid state at 77 298 K. Evidence for interfragment interactions based on comparison electronic band positions emission lifetimes,...
A series of new heterodinuclear luminescent complexes with two different organic ligands have been synthesized and characterized. Ru(II)(polypyridine) moiety a metal-based anticancer fragment (AuCl, (p-cymene)RuCl2, (p-cymene)OsCl2, (Cp*)RhCl2, or Au-thioglucose) are the general features these complexes. All bimetallic compounds evaluated for their antiproliferative properties in vitro human cancer cell lines. Only containing an Au(I) exhibit activity range cisplatin higher. The...
With the aim of exploiting use organometallic species for efficient modification proteins through C-atom transfer, gold-mediated cysteine arylation a reductive elimination process occurring from reaction cyclometalated Au
The mechanism of inhibition water and glycerol permeation <italic>via</italic> human aquaglyceroporin-3 (AQP3) by gold(<sc>iii</sc>) complexes has been described, for the first time, using molecular dynamics (MD), combined with density functional theory (DFT) electrochemical studies.
Cisplatin occupies a crucial role in the treatment of various malignant tumors. However, its efficacy and applicability are heavily restricted by severe systemic toxicities drug resistance. Our study exploits active targeting supramolecular metallacages to enhance activity cisplatin cancer cells while reducing toxicity. Thus, Pd2L4 cages (L = ligand) have been conjugated four integrin ligands with different binding affinity selectivity. Cage formation encapsulation was proven NMR...
The binding of Au(iii) complexes to the zinc finger domain anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex exposed two types fingers. Notably, cyclometallated Au-C^N identified as most selective candidate disrupt domain, forming distinct adducts compared coordination compound Auphen.
NaNO3 is used in oxidative Pd-catalyzed processes as a complementary co-catalyst to common oxidants, e.g., CuII salts, C-H bond activation and Wacker oxidation processes. NaNO2 (with air or O2) assist the sp3-C-H acetoxylation of substrates bearing an N-directing group. It has been proposed previously that redox couple operative. The role played by NOx anions examined this investigation. Evidence for anion interaction at PdII presented. Palladacyclic complexes containing are competent...
The nickel-dependent enzyme urease is a virulence factor for large number of critical human pathogens, making this potential target therapeutics the treatment resistant bacterial infections. In search novel inhibitors, five selected coordination and organometallic Au(III) compounds containing N∧N or C∧N C∧N∧N ligands were tested their inhibitory effects against Canavalia ensiformis (jack bean) urease. results showed potent inhibition with IC50 values in nanomolar range. 2.14 Å resolution...
Following our recent reports on the inhibition of water and glycerol channel aquaglyceroporin-3 (AQP3) by coordination complex [AuIII(1,10-phenanthroline)Cl2] (Auphen), a series six new Au(III) complexes featuring substituted 1,10-phenanthroline ligands (1–6) have been synthesized characterized. The speciation compounds studied in buffered solution UV–visible spectrophotometry showed that most remain stable for several hours. Quantum mechanics (QM) studies hydrolysis processes suggest they...
Within the framework of designing new self-assembled metallosupramolecular architectures for drug delivery, seven [Pd2L4]4+ metallacages (L = 2,6-bis(pyridine-3-ylethynyl)pyridine) featuring different groups in exo-position, selected to enhance cage solubility aqueous environment, were synthesized. Thus, carboxylic acids, sugars, and PEG tethered bispyridyl ligands directly or via disulfide bond formation, as well click chemistry. The respective cages characterized by methods, including NMR...
Gold compounds have been proven to be novel and versatile tools for biological applications, including as anticancer agents. Recently, we explored the potential of Au(III) complexes with bi-dentate N-donor ligands inhibitors membrane water glycerol channels aquaporins (AQPs), involved in different physiological pathophysiological pathways. Here, eight new featuring a pyridine-benzimidazole scaffold synthesized characterized via methods. The stability all aqueous solution their reactivity...
Polymer masked–unmasked protein therapy (PUMPT) uses conjugation of a biodegradable polymer, such as dextrin, hyaluronic acid, or poly(l-glutamic acid), to mask peptide's activity; subsequent locally triggered degradation the polymer at target site regenerates bioactivity in controllable fashion. Although concept PUMPT is well established, relationship between unmasking and reinstatement unclear. Here, we used dextrin–colistin conjugates study molecular structure (degree unmasking)...
The disulfide ligand (SC6H4CO2H-4)2 acts as a simple but versatile linker for range of group 8 transition metals through reaction the oxygen donors. This leads to homobimetallic ruthenium and osmium alkenyl compounds, [{M(CH═CHR)(CO)(PPh3)2(O2CC6H4S-4)}2] (M = Ru, Os; R C6H4Me-4). Additional metal-based functionality can be added use precursors incorporating rhenium bipyridine units (R (bpy)ReCl(CO)3). more robust diphosphine ligands in [{Ru(dppm)2(O2CC6H4S-4)}2]2+ (dppm...
The first example of an octadentate gadolinium unit based on DO3A (hydration number q=1) with a dithiocarbamate tether has been designed and attached to the surface gold nanoparticles (around 4.4 nm in diameter). In addition superior robustness this attachment, restricted rotation Gd complex nanoparticle leads dramatic increase relaxivity (r1 ) from 4.0 mm-1 s-1 unbound form 34.3 (at 10 MHz, 37 °C) 22±2 63.87 25 when immobilised surface. one-pot synthetic route provides straightforward...
A new gold(<sc>iii</sc>) complex bearing a 2-((2,2′-bipyridin)-5-yl)-1<italic>H</italic>-benzimidazol-4-carboxamide ligand has been synthesized and characterized for its biological properties <italic>in vitro</italic>.