A5049932518- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Microtubule and mitosis dynamics
- Prostate Cancer Treatment and Research
- Colorectal Cancer Treatments and Studies
- Chemical Reactions and Isotopes
- Genetic factors in colorectal cancer
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- FOXO transcription factor regulation
- Metamaterials and Metasurfaces Applications
- Advanced Antenna and Metasurface Technologies
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- International Science and Diplomacy
- Circular RNAs in diseases
- RNA modifications and cancer
- Antenna Design and Analysis
- GDF15 and Related Biomarkers
- Digestive system and related health
- Multiple and Secondary Primary Cancers
- Cancer-related Molecular Pathways
- Biomarkers in Disease Mechanisms
Institute of Molecular Biology and Genetics
2017-2024
National Academy of Sciences of Ukraine
2022-2023
Institute of Cell Biology
2018
Aim.To detect expression of EMT-related genes in prostate tumor samples and analyze a possible correlation between the gene level clinical characteristics cancer different groups.Methods.Expression 19 was analyzed 37 frozen tissues at stages Gleason scores, paired conventionally normal 20 adenomas, using quantitative PCR.Results.We have found that nine were expressed differently benign malignant tumors, namely AR (isoform 1), 2), PTEN, VIM, MMP9, KRT18, PCA3, HOTAIR SCHLAP1.When compared, we...
The study aimed to identify the clinically relevant gene variants in colon adenocarcinoma samples of Ukrainian patients using NGS Comprehensive Cancer Panel (CCP) implement them conveniently clinical practice. Methods. We have studied 20 with colorectal adenocarcinomas various differentiation grades. To variants, CCP data were filtered Franklin by Genoox database. Results. A total 79 variant alterations (SNVs, INDELs) found 28 409 genes. largest number mutations was 3 genes, APC, TP53, and...
• TTP expression level differs in different breast cancer subtypes. HER2-enriched samples have the highest of expression. Temozolomid and doxorubicin influence TTPs methylation status.
aurora kinases a and B play crucial role in the regulation of mitosis, while c controls meiotic division.these proteins showed controversial behavior upon development epithelial tumors.Our aim was to examine if there are any differences expression Aurora genes malignant non-malignant tumors non-tumor tissues; compare their with clinical characteristics patients other prostate cancer-associated genes.Quantitative rt-Pcr used determine a-c 33 adenocarcinomas (t), paired conventionally normal...
Keywords: Circular RNA (circRNA), binding proteins (RBPs), backsplicing model, lariat the circulating cell-free RNA, cancer-related circRNA
The present study aimed to investigate the dynamic changes in peripheral blood leucocyte subpopulations, cytokine and miRNA levels, computed tomography (CT) scores patients with severe coronavirus disease 2019 (COVID-19) (n=14) age-matched non-COVID-19 volunteers (n=17), which were included as a reference control group. All data collected on day of patient admission (day 0) 7th, 14th 28th days follow-up while CT lungs was performed weeks 2, 8, 24 48. On 0, lymphopenia leucopenia detected...
Background.Prostate cancer is one of the most common type diagnosed worldwide and in Ukraine particularly.Today problem its early detection unsolved.The use epigenetic markers, namely, tumor suppressor genes methylation, a promising tool to assess risks disease diagnosis.Along with that, we investigate fundamental features prostate cancer, such as expression specific oncogenes.The aim this study was examine methylated unmethylated status PTEN, GDF15, NKX3.1, RASSF, CDH1 KRT18 urine patients...
Hyperbolic metasurfaces exhibit a lot of unique properties including negative refraction, hyperlensing, surface waves manipulation and optical sensing. In this work, we provide the practical guide hyperbolic engineering. First, retrieve conductivity metasurface consisting gold nanodisks from reflectance spectrum. Then, analyze dependence resonant wavelengths spectral width regime on period size nanodisks. The results obtained may be used to design based nanoparticles for any relevant purpose demand.
The All-Ukrainian Conference on Molecular and Cell Biology with international participation was held as an online event the Zoom platform, from 15th to 17th of June 2022. purpose this encourage Ukrainian scientists, give opportunity colleagues abroad demonstrate their support Ukraine, keep scientific process ongoing even in background war. Scientists every career stage could take part any way convenient them. Seven sections bioscience were available at Conference, namely: Microbiology...
Keywords: gene promoter methylation, tumor suppressor genes, noninvasive diagnostics, prostate cancer