A5087506744- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Central Venous Catheters and Hemodialysis
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Effects of Exercise
- Pericarditis and Cardiac Tamponade
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Social and Educational Sciences
- Acute Ischemic Stroke Management
- Myasthenia Gravis and Thymoma
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Language, Discourse, Communication Strategies
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
Copenhagen University Hospital
2019-2024
Gentofte Hospital
2021-2024
University of Copenhagen
2021-2024
Guidelines recommend prioritizing treatment with antiarrhythmic drugs before referral of patients atrial fibrillation to ablation, delaying a potential subsequent ablation. However, ablation may affect outcomes. We sought investigate the impact duration from diagnosis on risk recurrence and adverse events.
Abstract Aims Overweight is associated with increased risk of atrial fibrillation (AF), but the impact overweight and AF recurrence after ablation less clear. Despite this, an increasing number ablations are carried out in patients. We investigated body mass index (BMI) on rates ablation. Methods results Through Danish nationwide registers, all patients undergoing first-time between 2010 2018 were identified. Exposure interest was BMI. The primary outcome recurrent AF, defined from either...
Abstract Aims Catheter ablation (CA) is a well-established treatment option for atrial fibrillation (AF), where sedation and analgesia are pivotal patient comfort lesion formation. The impact of anaesthesia type on AF recurrence rates remains uncertain. This study aimed to examine depending conscious (CS) vs. general (GA) during CA. Methods results Utilizing nationwide data from the Danish healthcare registries, we conducted this cohort involving adults (≥18 years) undergoing first-time CA...
The treatment of atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) can be challenging since AF aggravates symptoms and increases the risk stroke. Which factors contribute to development stroke HCM remains unknown. aim this study was determine incidence patients identify factors.
The temporal relationship between cirrhotic cardiomyopathy, progression of liver disease, and survival remains unknown. Our aim was to investigate the development structural functional cardiac changes over time with cirrhosis outcome. Sixty-three outpatients (Child class: A = 9, B 46, C 8) 14 healthy controls were included in this 2-yr longitudinal study. Advanced characteristics such as MRI extracellular volume (ECV) quantification, speckle tracking echocardiography, biomarkers assessed at...
The elderly population with atrial fibrillation (AF) is growing. There limited evidence to suggest AF ablation as an effective treatment for the elderly.
To investigated the prognosis of most prevalent cancers (breast-, gastrointestinal-, and lung cancer), according to cancer status (i.e., active-, non-active-, history of-, no following first-time acute coronary syndrome (ACS).Danish nationwide registers were used identify patients with ACS from 2000-2018. Patients stratified type status. Hazard ratios (HR) estimated by adjusted Cox regression models for 1year all-cause mortality reported. Further absolute risks cardiovascular versus...
Cancer is a well-known risk factor of venous thromboembolism (VTE). Some cancers are believed to be more thrombogenic. The purpose this study was investigate the characteristics patients with incident gastrointestinal (GI) and their associated 1-year timing thromboembolic events mortality. This retrospective cohort study. Through Danish nationwide registries, all first-time GI cancer diagnosis from 2008 2018 were identified. Incident VTE identified within follow-up after using Aalen-Johansen...
Expected 1-year survival is essential to risk stratification of patients with heart failure (HF); however, little known about the prognosis HF and cancer. Thus, objective was investigate following new-onset stratified by cancer status in breast, gastrointestinal, or lung cancer.All Danish from 2000 2018 were included. Cancer categorized as history (no cancer-related contact within 5 years diagnosis), non-active (curative intended procedure administered) active Standardized all-cause...
BackgroundPulmonary embolism (PE) is described as a prognostic factor in patients with cancer however, the impact of PE remains unknown. This study investigated, 1-year prognosis following breast-, gastrointestinal-, or lung stratified by status.MethodsAll Danish first-time from 2008 to 2018 were included. Cancer status was categorized no cancer, history non-active and active cancer. Unadjusted age-stratified risk death estimated using Kaplan-Meier estimator. Cause reported Aalen-Johansen...
Abstract Introduction Three randomised controlled trials (RCTs) have demonstrated that first-line cryoballoon pulmonary vein isolation decreases atrial tachycardia in patients with symptomatic paroxysmal fibrillation (PAF) compared antiarrhythmic drugs (AADs). The aim of this study was to develop a cost-effectiveness model (CEM) for cryoablation AADs the treatment PAF. used Danish healthcare perspective. Methods Individual patient-level data from Cryo-FIRST, STOP AF and EARLY-AF RCTs were...
Atrial fibrillation (AF) is a common arrhythmia associated with reduced quality of life that can lead to serious complications such as stroke and heart failure. Ablation safe effective treatment for AF but not offered equally all patients. The aim this study identify demographic groups more or less likely undergo ablation.
Electrical cardioversion (ECV) is a common procedure for terminating atrial fibrillation (AF). ECV associated with brady-arrhythmic events, however, the age-specific risks of clinically significant events are unknown.Using Danish nationwide registers, we identified patients AF at their first non-emergent between 2005 and 2018 estimated 30-day risk events. Moreover, factors increased brady-arrhythmias were identified. Absolute using logistic regression models fitted natural splines as well...
Abstract Introduction Cryoballoon ablation is a safe and efficient rhythm control strategy in atrial fibrillation (AF) patients. The impact of time from diagnosis to unclear. aim this study was examine the timing first‐time cryoballoon on AF recurrence nationwide cohort Methods Results From registers, all patients ≥18 years age who underwent Denmark 2012 2018 were included. stratified by timing: Early group (≤1 year after diagnosis), intermediate (1–3 late (≥3 diagnosis). By adjusted Cox...
Abstract Background Catheter ablation (CA) is a well-established treatment option for recurrent atrial fibrillation (AF), and has shown to outperform antiarrhythmic drugs in prevention of AF recurrences numerous studies. However, up 50% patients with persistent (peAF) will experience after first-time CA. Improving these involves, choosing the right procedure, optimizing timing using most effective strategy. This benefit not only patients, but also target recourse use healthcare system....
Abstract Background As demonstrated in three randomized clinical trials (RCTs), initial rhythm control with first-line pulmonary vein isolation (PVI) using cryoballoon ablation decreases atrial arrhythmia recurrence compared to antiarrhythmic drug (AAD) therapy patients symptomatic paroxysmal fibrillation (PAF). Purpose To assess the cost-effectiveness of cryoablation versus AADs a Danish healthcare setting. Methods Data from 703 participants PAF enrolled into Cryo-FIRST, STOP AF First and...
To describe the population of patients diagnosed with hypertrophic cardiomyopathy (HCM) in Denmark and determine temporal trends incidence patient characteristics over time. Nationwide retrospective cohort study. Danish nationwide administrative clinical registers databases. All aged ≥16 years HCM from 2005 to 2018. Time diagnosis, characteristics, comorbidities pharmacotherapy were identified tested for significance using Cochran-Armitage trend test. 3856 included (median age 68 (IQR...
Abstract Background and aims Trends in patient selection use of pharmacotherapy prior to catheter ablation (CA) for supraventricular tachycardia (SVT) are not well described. This study examined temporal trends patients undergoing first-time CA regular SVT, including atrioventricular nodal re-entry (AVNRT), accessory pathways (APs), ectopic atrial (EAT) on a nationwide scale Denmark the period 2001–2018. Methods results Using Danish Nationwide registers, 9959 treated with SVT between 2001...
Abstract Introduction Treatment with catheter ablation (CA) as rhythm control is increasingly used in atrial fibrillation (AF). Pulmonary vein isolation (PVI) alone less effective patients persistent AF (peAF) compared to paroxysmal (PAF). Strategies and methods optimize outcome for peAF still an ongoing challenge. Additional pulmonary (PVI plus) PVI has so far shown conflicting evidence yet be tested a large unselected, real-life population longtime follow-up. Purpose To examine recurrence...