A5024624714- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Adsorption and biosorption for pollutant removal
- Quinazolinone synthesis and applications
- Extraction and Separation Processes
- Surfactants and Colloidal Systems
- Chemical Synthesis and Analysis
- Cancer Mechanisms and Therapy
- Advanced Polymer Synthesis and Characterization
- Chemical Synthesis and Characterization
- Multicomponent Synthesis of Heterocycles
- Nanomaterials for catalytic reactions
- Synthesis of heterocyclic compounds
- biodegradable polymer synthesis and properties
- HER2/EGFR in Cancer Research
- Synthesis and Reactions of Organic Compounds
- Cancer therapeutics and mechanisms
- Crystallography and molecular interactions
- Environmental Chemistry and Analysis
- Metal complexes synthesis and properties
- Natural Antidiabetic Agents Studies
Suez Canal University
2013-2025
University of Zurich
2005
A series of methyl 2-[3-(3-phenyl-quinoxalin-2-ylsulfanyl)propanamido]alkanoates and their corresponding hydrazides N-alkyl 3-((3-phenylquinoxalin-2-yl)sulfanyl)propanamides were prepared on the basis chemoselective Michael reaction acrylic acid with parent substrate 3-phenylquinoxaline-2(1H)-thione. The thione was produced by a convenient novel thiation method from 3-phenylquinoxalin-2(1H)-one. chemical structures newly synthesized compounds confirmed elemental analyses, 1H 13C NMR....
Aflatoxin B1 (AF) is an unavoidable environmental pollutant that contaminates food, feed, and grains, which seriously threatens human animal health. Arabic gum (AG) has recently evoked much attention owing to its promising therapeutic potential. Thus, the current study was conducted look into possible mechanisms beyond ameliorative activity of AG against AF-inflicted hepatic injury. Male Wistar rats were assigned four groups: Control, (7.5 g/kg b.w/day, orally), AF (200 µg/kg b.w), plus...
The parent 2-(4-benzyl-1-oxophthalazin-2(1H)-yl)-acetohydrazide (4) has twenty-nine compounds. starting material for their corresponding mono, dipeptides and reactions with active methylene compounds were produced by chemoselective N-alkylation of 4-Benzyl-2H-phthalazin-1-one (2) ethyl chloroacetate to afford (4-benzyl-1-oxo-1H-phthalazin-2-yl) methyl acetate (3). ester 3 was hydrazinolyzed give hydrazide 4, then azide 5 coupled amino acid hydrochloride and/or amines produce several...
Seventeen 3-alkylaminoquinoxaline-2(1H)-thiones and 3-alkyloxyquinoxaline-2(1H)-thiones were prepared by a novel thionation protocol from the readily available quinoxaline-2,3-dione in excellent overall yields. This starts with chlorination of dione using thionyl chloride to give 2,3-dichloroquinoxaline followed reaction equimolar amounts N-nucleophiles (primary amines secondary amines) or O-nucleophiles (phenols alcohols) principally afford 2-alkanamino-3-chloroquinoxalines...
One of the most dangerous types breast cancer that can spread from its original location to neighboring tissues is invasive cancer. Cathepsins, a group proteolytic enzymes, has been thoroughly investigated in relation progression and shown be crucial for invasion metastasis cells. A series new N-alkyl-2-(2-undecyl-1H-benzimidazol-1-yl) acetamides were prepared 2-(2-undecyl-1H-benzimidazol-1-yl)ethanhydrazide via azide coupling method with variety amines. The compounds designed inhibit...
In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)alkanoates 6a–c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)alkanamides 9–10(a–h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11–12(a–e) were via azide coupling. Hydrazones 13–15 condensation 7a,b 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular...
The parent ester methyl-3-[2-(4-oxo-3-phenyl-3,4-dihydro-phthalazin-1-yloxy)-acetylamino] has 18 compounds. starting material for alkanoates, their corresponding hydrazides, hydrazones, and dipeptides were produced by chemoselective O-alkylation of 2-phenyl-2,3-dihydrophthalazine-1,4-dione with ethyl chloroacetate(4-oxo-3-phenyl-3,4-dihydro-phthalazin-1-yloxy) acetic acid methyl ester. was hydrazinolyzed, then azide coupled amino hydrochloride to produce several esters, hydrazinolyzed...
Encapsulation of semiconductor materials in zeolites is one the important types composites that have been used as photocatalysts degradation several organic dyes. The high surface area and uniform porous structure zeolite particles prevent coagulation catalyst ensure its stability dispersion. strong polarised electrostatic field can decrease energy consumption needed to facilitate electrons transfer from valence band conduction band. So, this paper, ethylenediaminetetraacetic acid disodium...
Diabetes mellitus (DM) is a category of metabolic illness characterized by high blood sugar levels and insufficient pancreatic insulin production or activity within the body. The most common type diabetes II diabetes, which condition resistance islet β-cell failure, resulting in hyperglycemia. goal this study was to examine anti-diabetic implications zinc oxide nanoparticles (ZnO NPs) and/or pyrazolopyrimidine diabetic rats. Rats with weight 150 ± 20 g were used. Animals divided into five...
Aflatoxin B1 (AFB1) is a common environmental pollutant that poses major hazard to both humans and animals. Acacia senegal (Gum) well-known for having antioxidant anti-inflammatory bioactive compounds. Our study aimed scout the nephroprotective effects of gum against AFB1-induced renal damage. Four groups rats were designed: Control, Gum (7.5 mg/kg), AFB1 (200 µg/kg b.w) AFB1-Gum, co-treated with AFB1. Gas chromatography-mass spectrometry (GC/MS) analysis was done determine phytochemical...
Breast cancer is the most predominant cause of death in women globally. The current study was performed to evaluate possible protective role wheat germ oil (WGO), powder (WGP), and vitamin E (Vit E) against breast carcinoma induced by environmental carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) Sprague Dawely albino rats. Eighty female rats were divided into eight groups, each ten All agents taken 21 days prior DMBA treatment. Group I served as normal control. II received Vit (100 mg/kg...
A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.
Novel semisynthetic coumarin derivatives were synthesized to be developed as chemotherapeutic anticancer agents through topoisomerase II, VEGFR2 inhibition that leads apoptotic cancer cell death. The amino acids and dipeptides prepared by the reaction of coumarin-3-carboxylic acid with methyl esters following N,N-dicyclohexylcarbodiimide (DCC) method 1-hydroxy-benzotriazole (HOBt), coupling reagents. compounds screened towards VEGFR2, IIα proteins highlight their binding affinities virtual...
A new and convenient synthesis of a variety methyl-2- (2-(4,5-dihydro-4-methyl-5-oxo-[1,2,4]triazolo [4,3-a]quinazolin-1-yl-thio) acetamido propanamido alkanoate 8a-h 9a-c, respectively has been developed via azide DCC coupling methods.Hydrazinolysis the ester 8a-g gave hydrazide 10a-g, which subsequently reacted with furfural to give hydrazone 11a-f.Compounds 8-11 might show non sedative H1-antihistamines activities.Compounds were characterized by elemental analysis, IR, mass 1 H NMR data.
We have designed a series of quinoxalinepeptidomimetic derivatives based on our previously reported scaffold in an attempt to find promising lead compound.
Abstract Utilization of the nano‐catalysts in synthesis applicable heterocycles is a key focus research green chemistry. The present work describes one‐pot, three‐component, simple, and efficient approach for new series N ‐bridged pyrido[1,2‐ ]pyrimidine candidates utilizing NiO‐NPs as catalyst. α‐Aminopyridine 1 was synthesized from one‐pot condensation 4‐chlorobenzaldehyde, chloroacetyl chloride, malononitrile presence ammonium acetate. condensed with variety aromatic or/heteroaromatic...
Methyl N-[2-(benzoylamino)benzoyl]-2-aminoalkanoates 4a-d were efficiently prepared by DCC coupling of 2-benzoylamino-benzoic acid 1 with amino methyl esters; or alternatively reaction esters 2-phenyl-4H-benzo [d][1,3]oxazin-4-one (2).Dipeptides 7a-k subsequently following the azide-coupling method from 4.
This study describes a promising one-pot synthesis of [2-(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetyl]-amino acid methyl esters 6a-h and dipeptides 10a-e, which were successfully synthesized starting from amino 5a-h, 9a-e azides 4, 8a,b, respectively. On the other hand, azide 4 underwent Curtius rearrangement to corresponding isocyanate, subsequently reacted with selected aliphatic amine and/or aniline derivatives give urea 11 12a,b. Reactions isocyanate secondary amines gave amide...