A5101989029- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Nutrition and Health in Aging
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Frailty in Older Adults
- Bone health and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Quality and Management
- Clinical practice guidelines implementation
- Infectious Diseases and Tuberculosis
- PI3K/AKT/mTOR signaling in cancer
- Esophageal Cancer Research and Treatment
- Medical Imaging and Pathology Studies
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Dysphagia Assessment and Management
- Neonatal Respiratory Health Research
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
Severance Hospital
2015-2023
Yonsei University
2015-2023
Gangnam Severance Hospital
2017-2018
Abstract Adequate preclinical model and establishment procedure are required to accelerate translational research in lung cancer. We streamlined a protocol for establishing patient-derived cells (PDC) identified effective targeted therapies novel resistance mechanisms using PDCs. generated 23 PDCs from 96 malignant effusions of 77 patients with advanced adenocarcinoma. Clinical experimental factors were reviewed identify determinants PDC establishment. characterized by driver mutations vitro...
Abstract Bone metastasis is known as a poor prognostic factor in colorectal cancer (CRC), but its clinical manifestations and outcomes are uncertain. CRC with bone was searched from January 2006 to April 2016. Of 11,551 patients, 321 (2.7%) patients had metastasis. Bone-only found only 8.7% of patients. Synchronous present 147 (45.8%) In metachronous metastasis, the median time diagnosis (TTB) 27.2 months. KRAS mutation status marginally significant affecting TTB (median TTB, wild-type or...
Purpose Metastatic biliary tract cancer (mBTC) has a dismal prognosis. In this study, an independent dataset of patients with mBTC was used to implement and validate routine clinico-laboratory parameter-based scoring model for risk group identification. Materials Methods From September 2006 February 2015, 482 were assigned randomly (ratio, 7:3) into investigational (n=340) validation datasets (n=142). The continuous variables dichotomized using normal range or the best cutoff values...
The treatment of Lung adenocarcinoma (LUAD) could benefit from the incorporation precision medicine. This study was to identify cancer-related genetic alterations by next generation sequencing (NGS) in resected LUAD samples Korean patients and determine their associations with clinical features. A total 201 tumors matched peripheral blood were analyzed using targeted via Illumina HiSeq 2500 platform 242 genes a median depth coverage greater than 500X. One hundred ninety-two amenable data...
Abstract Health outcomes of the elderly vary between rural and urban areas. Sarcopenia is diagnosed as loss muscle strength or impaired physical performance, namely “low function” low mass. Outcomes mass function are not equal. This study aimed to investigate prevalence mass, function, sarcopenia in populations determine whether regional differences were associated with each these components. Participants aged ≥ 69 years (n = 2354) recruited from three districts one district Korea. Low was...
IntroductionWhether patients with resectable colorectal liver metastases (CRLM) gain a survival benefit from perioperative chemotherapy remains controversial. The of including bevacizumab in also unclear.Material and MethodsSeventy-six CRLM were randomly assigned to either 6 cycles FOLFOX (folinic acid, 5-fluorouracil, oxaliplatin)/FOLFIRI irinotecan) before after surgery or 12 surgery. Progression-free (PFS) was estimated using the Kaplan-Meier method compared by log-rank test.ResultsThe...
Purpose: This study aimed to determine the prognostic value of new quantitative parameters 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally advanced and metastatic gallbladder cancer (GBC).Materials Methods: In total, 83 initially diagnosed GBC who underwent PET/CT at time initial diagnosis were retrospectively reviewed.The volume-based PET primary tumors lesions measured, maximum...
The prognostic value of a comprehensive geriatric assessment (CGA) for the management older small cell lung cancer (SCLC) patients remains to be established.A retrospective cohort enrolled 21 SCLC over 65 years from March 2018 2019 at Yonsei Cancer Center. CGA included following instruments: frailty, body mass index, sarcopenia (circumference arm and calf, Timed Up Go test, grip strength), comorbidity, polypharmacy, activities daily living (ADL), Instrumental ADL, nutrition, depression,...
The direct impact of hospital accreditation on patients’ clinical outcomes is unclear. purpose this study was to evaluate whether mortality within 30 days hospitalization for acute myocardial infarction (AMI), ischemic stroke (IS), and hemorrhagic (HS) differed before after accreditation. This targeted patients who had been hospitalized the three diseases at general hospitals newly accredited by government in 2014. Thirty-day rates years were compared. Mortality lower than (7.34% vs. 6.15%...
Hospital accreditation programs are used worldwide to improve the quality of care and patient safety. It is great help in improving structure hospitals, but there mixed research results on clinical outcome patients. The purpose this study was compare levels core indicators after receiving inpatient services from accredited nonaccredited hospitals patients with acute myocardial infarction (AMI). For all AMI admitted general Korea 2010 2017, their 30-day mortality readmissions length stay were...
Kaposi’s sarcoma (KS) is an unusual multifocal neoplastic angioproliferative disorder. We herein report a case of classic KS that occurred in patient receiving hemodialysis for 7 years. The had history chronic renal failure due to glomerulonephritis 20 Multiple reddened violaceous patches, plaques, and nodules were found on the right knee. Biopsy revealed positivity human herpesvirus 8 (KS-associated herpesvirus) consistent with KS. Pazopanib, multitarget tyrosine kinase inhibitor, effective...
Lemierre syndrome is characterized by anaerobic bacterial infection in the head and neck clinical or radiological evidence of internal jugular vein thrombophlebitis. The most common pathogens are Fusobacterium species, particularly necrophorum . Septic emboli resulting from infected thrombophlebitis leads to metastatic infections involving lung, liver, kidney, bone central nervous system. accurate diagnosis treatment important because it may be associated with a high mortality rate if...
3528 Background: Whether patients with resectable colorectal cancer liver metastases (CRLM) gain a survival benefit or not from neoadjuvant chemotherapy remains controversial. The addition of bevacizumab to also unclear. Methods: 76 CRLM were randomly assigned either six cycles FOLFOX FOLFIRI before and after surgery twelve surgery. primary objective was detect DFS. analysis by intention treat DFS estimated the Kaplan-Meier method compared log-rank test. This trial registered...
Abstract Background The prognostic value of a comprehensive geriatric assessment (CGA) for the management older cancer patients remains to be established. This study investigated association each CGA variable with overall survival (OS) in small cell lung (SCLC) patients. Methods A retrospective cohort enrolled 21 SCLC over 65 years from March 2018 2019 at Yonsei Cancer Center. was performed before treatment and included following instruments: Frailty, circumference arm/calf, body mass index...