A5101941457- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- Genetic factors in colorectal cancer
- Computational Drug Discovery Methods
- Melanoma and MAPK Pathways
- Immunodeficiency and Autoimmune Disorders
- Bone Metabolism and Diseases
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- S100 Proteins and Annexins
- Hydrocarbon exploration and reservoir analysis
- dental development and anomalies
- Mining and Gasification Technologies
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Psoriasis: Treatment and Pathogenesis
- Paleontology and Stratigraphy of Fossils
- Phytase and its Applications
- CO2 Sequestration and Geologic Interactions
- Cancer and Skin Lesions
- Cell death mechanisms and regulation
- Glutathione Transferases and Polymorphisms
Eötvös Loránd University
2025
Országos Idegsebészeti Tudományos Intézet
2023-2024
National Institute of Oncology
2012-2024
National Institute of Criminology
2020
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2013-2016
Abstract Stromatolites can be traced back to ∼3.5 billion years. They were widespread in the shorelines of ancient oceans and seas. However, they are uncommon nowadays, basic information is lacking about how these unique carbonate structures developed. Here we study unusually thick (3–5 cm) biofilms 79.2 °C outflow from Köröm thermal well (Hungary) demonstrate that its microbial mat – architecture similar fossilized microdigitate stromatolites. Our observations reveal vertically oriented...
Osteopontin is a proinflammatory cytokine and plays pathogenetic role in multiple sclerosis its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. functions are modulated thrombin cleavage generating N- C-terminal fragment, whose individual roles only partly known. Published data difficult to compare since they have been obtained with heterogeneous approaches. Interestingly, of osteopontin unmasks cryptic domain...
Abstract Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production resorption, which crucial homeostasis. OC hyperactivation plays a role exaggerated resorption of diseases such as osteoporosis, rheumatoid arthritis, osteolytic tumor metastases. This work stems from finding that OCs can express B7h (ICOS-Ligand), is ligand ICOS T cell costimulatory molecule. Because recent reports have shown that, endothelial, dendritic, cells, triggering modulates several activities...
EZH2 (Enhancer of zeste homolog 2) promotes tumor growth and survival through numerous mechanisms is a promising target for novel therapeutic approaches. We aimed to characterize the expression in tumors young head-and-neck squamous cell cancer (HNSCC) patients comparison with general HNSCC patient population. used formalin-fixed, paraffin-embedded tissue blocks from 68 random (≤39 years, median age: 36 years; diagnosed between 2000 2018), which were compared samples 58 age- gender-matched...
Introduction: The aim of our study was to correlate Maspin expression, a serine protease with possible antiangiogenic and antiproliferative effects, angiogenesis realize synthesis the literature data regarding novel patented compounds used in colorectal cancer (CRC). Keywords: Angiogenesis, cancer, Maspin, tumor stage
The implementation of targeted therapies revolutionized oncology. As the number new oncogenic driver mutations, which provide molecular targets for prediction effective and selective therapies, is increasing, fast reliable methods by pathology labs very important. Here we report our results with TruSeq Custom Amplicon assay performed on formalin-fixed paraffin-embedded material. oligo capture probes hotspot regions 10 well-known oncogenes linked to clinical diagnosis treatment lung...
Background. The dual role of GCs has been observed in breast cancer; however, due to many concomitant factors, GR action cancer biology is still ambiguous. In this study, we aimed unravel the context-dependent cancer. Methods. expression was characterized multiple cohorts: (1) 24,256 specimens on RNA level, 220 samples protein level and correlated with clinicopathological data; (2) oestrogen receptor (ER)-positive -negative cell lines were used test for presence ER ligand, effect GRβ isoform...
Background: Chemotherapeutic agents are often mutagenic. Induction of mutation associated neo-epitopes is one the mechanisms by which chemotherapy thought to increase number tumor-infiltrating lymphocytes. It not known, however, whether treatment with various chemotherapeutic different mutagenic capacity induce a significantly stromal lymphocytes (StrTIL) in residual cancer.Methods: One hundred and twenty breast carcinoma cases disease that were treated three types pre-operative regimens...
Gorlin-Goltz syndrome (GGS) or nevoid basal cell carcinoma is a rare tumour-overgrowth associated with multiple developmental anomalies and wide variety of tumours. Here, we describe case man aged 23 years GGS bilateral giant tumours adjacent to both adrenals that raised the suspicion malignancy on imaging. Histological analysis surgically resected revealed perivascular epitheloid (PEComas) were independent adrenals. Exome sequencing patient's blood sample novel germline heterozygous...
The V600E mutation is the most common (~90%) activating of BRAF gene. mutations have been frequently investigated in melanoma, colorectal cancer and papillary thyroid carcinoma. importance detection has rising by routine use Braf inhibitor therapy. We evaluated usefulness mutation-specific monoclonal antibody (VE1) metastatic melanoma patients. To confirm results immunohistochemistry (IHC), we used COBAS 4800 V600 test PCR amplification followed Sanger sequencing.36 105 patients wild-type...