A5075108256- Veterinary Pharmacology and Anesthesia
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Maternal Mental Health During Pregnancy and Postpartum
- Pain Management and Opioid Use
- Hormonal Regulation and Hypertension
- Maternal and Perinatal Health Interventions
- Pharmacology and Obesity Treatment
- Veterinary Equine Medical Research
- Drug-Induced Hepatotoxicity and Protection
- Adrenal Hormones and Disorders
- Pharmacogenetics and Drug Metabolism
- Bariatric Surgery and Outcomes
- Cholesterol and Lipid Metabolism
- Prenatal Substance Exposure Effects
- Malaria Research and Control
- Pediatric Pain Management Techniques
- Breastfeeding Practices and Influences
- Gastrointestinal motility and disorders
- Infectious Encephalopathies and Encephalitis
- Maternal and fetal healthcare
- Anesthesia and Pain Management
- Pharmacological Effects and Assays
Machida Endoscope (Japan)
2019-2023
Turku University Hospital
2016
University of Turku
2013-2016
University of Eastern Finland
2007-2008
Low 25-hydroxyvitamin D levels correlate with the prevalence of diabetes; however, mechanisms remain uncertain. Here, we show that nutritional deprivation–responsive regulate vitamin metabolism. Both fasting and diabetes suppressed hepatic cytochrome P450 (CYP) 2R1, main 25-hydroxylase responsible for first bioactivation step. Overexpression coactivator peroxisome proliferator–activated receptor γ 1-α (PGC-1α), induced physiologically by pathologically in diabetes, resulted dramatic...
A new inhibitor for human sirtuin type proteins 1 and 2 (SIRT1 SIRT2) was discovered through virtual database screening in search of scaffolds. series compounds synthesized based on the hit compound (3-[[3-(4-tert-butylphenyl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-(trifluoromethyl)phenyl]thiourea). The most potent nearly as reference (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide).
Growing evidence supports the use of (2<i>R-trans</i>)-<i>N</i>-(2-(1,3,4,7,12<i>b</i>-hexahydro-2′-oxo-spiro(2<i>H</i>-benzofuro(2,3-<i>a</i>)quinolizine-2,4′-imidazolidin)-3′-yl)ethyl) methanesulfonamide (MK-467), a peripherally acting α<sub>2</sub>-adrenoceptor antagonist, in conjunction with sedative-anesthetic agent dexmedetomidine animals to avoid hemodynamic compromise. We evaluated possible effects different doses MK-467 on plasma concentrations eight beagle dogs. Both drugs were...
Liver X receptors (LXRs) are expressed in placenta and may be associated with pre-eclampsia (PE). Oxysterols act as agonists for LXRs. We recently proposed a new blood pressure-regulating circuit oxysterol 4β-hydroxycholesterol (4βHC) acting hypotensive factor via This study investigated the association between maternal plasma 4βHC, pressure (BP) indices, placental expression of LXR target genes, patient characteristics using data from Finnish Genetics Pre-Eclampsia Consortium (FINNPEC)...
We investigated the influence of peripherally acting α2 -adrenoceptor antagonist MK-467 on sedative and antinociceptive actions plasma drug concentrations medetomidine, an agonist that is used in veterinary medicine as a analgesic agent. Eight healthy beagle dogs received intravenous medetomidine (10 μg/kg) or with (250 randomized crossover design. A standardized nociceptive pressure stimulus was applied to nail bed hindlimb. Times for withdrawal limb head lift were measured, sedation...
ObjectiveTo study the effects of oromucosal detomidine gel administered sublingually to calves prior disbudding, and compare its efficacy with intravenously (IV) detomidine.Study designRandomised, prospective clinical study.AnimalsTwenty dairy aged 12.4 ± 4.4days (mean SD), weight 50.5 9.0 kg.MethodsDetomidine at 80 μg kg−1 was ten (GEL) 30 control IV (V. jugularis). Meloxicam (0.5 mg kg−1) local anaesthetic (lidocaine 3 were before heat cauterization horn buds. Heart rate (HR), body...
Both effective analgesia and early breastfeeding play an important role in maternal neonatal well-being after Caesarean delivery. We studied controlled-release oxycodone tablet treatment for postoperative pain management determined the excretion of into breast milk.
Regardless of progress in treatment coronary artery disease (CAD), there is still a significant residual risk death patients with CAD, highlighting the need for additional stratification markers. Our previous study provided evidence novel blood pressure-regulating mechanism involving 4β-hydroxycholesterol (4βHC), an agonist liver X receptors, as hypotensive factor. The aim was to determine role 4βHC prognostic factor CAD.
Abstract Oxycodone is an opioid analgesic with several pharmacologically active metabolites and relatively narrow therapeutic index. Cytochrome P450 (CYP) 3A4 CYP2D6 play major roles in the metabolism of oxycodone its metabolites. Thus, inhibition induction these enzymes may result substantial changes exposure both In this study, a physiologically based pharmacokinetic (PBPK) model was built using GastroPlus™ software for oxycodone, two primary (noroxycodone, oxymorphone) one secondary...
While a drug treatment is unavailable, the global incidence of Dengue virus (DENV) infections and its associated severe manifestations continues to rise. We report construction first physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model that predicts viremia levels in relevant target organs on preclinical data with broad spectrum antiviral soraphen A (SorA), an inhibitor host cell acetyl-CoA-carboxylase. SorA was highly effective against DENV vitro (EC50 = 4.7 nM) showed vivo...
Cardiac bypass surgery patients have early postoperative interventions that elicit breakthrough pain. We evaluated the use of intranasal fentanyl for pain management in these patients. Multimodal analgesia (paracetamol 1 g three times a day, oxycodone 2–3 mg boluses with patient-controlled intravenous pump) was used 16 (age 49–70 years, weight 59–129 kg) after cardiac surgery. Intranasal 100 µg or 200 to manage on first and third mornings randomised order. Blood samples were collected up 3 h...
Opioids are used for pain relief during the first stage of labor. Oxycodone can cause maternal hypotension that may modify utero- and fetoplacental circulatory physiology. We hypothesized intravenous (i.v.) oxycodone has no detrimental effect on hemodynamics early labor.Twenty-two parturients requiring labor were randomized in a double-blinded placebo-controlled study. By Doppler ultrasonography, both uterine artery (Ut) umbilical vein (UV) volume blood flows (Q), Ut pulsatility index (PI),...
The pharmacokinetic profile of fat-soluble vitamins A, E, K1, and D3 co-administered with liquid paraffin or water in an experimental rat model was investigated. Animals received a solution the four orally through probe, followed 10 minutes later by administration either product dissolved (Emuliquen Simple®) (control). Vitamin formulations were 20, 50, 0.30 0.10 mg/kg for D3, respectively. Blood samples collected before dosing at 0.17, 1, 2, 4, 8, 24 hours post-dosing. concentrations...