A5101719011- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Mechanical Circulatory Support Devices
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrochemical Analysis and Applications
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Nanocluster Synthesis and Applications
- Viral Infections and Vectors
- Intensive Care Unit Cognitive Disorders
- Mosquito-borne diseases and control
- DNA and Nucleic Acid Chemistry
- Molecular Sensors and Ion Detection
- Advanced Nanomaterials in Catalysis
- Insect symbiosis and bacterial influences
- Cardiac Ischemia and Reperfusion
- Immune Response and Inflammation
- Hemoglobin structure and function
- Transplantation: Methods and Outcomes
- Helicobacter pylori-related gastroenterology studies
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
Tianjin University
2021-2025
Wenzhou University
2022-2025
Shanghai Veterinary Research Institute
2018-2022
Chinese Academy of Agricultural Sciences
2018-2022
University of Jinan
2018-2021
Institute of Disaster Prevention
2021
Beijing Agricultural Machinery Research Institute
2021
Multiplexed detection of Alzheimer's disease (AD) core biomarkers is great significance to early diagnosis and personalized treatment AD patients. Herein, we construct a robust convenient surface-enhanced Raman scattering (SERS) biosensing platform for simultaneous Aβ(1–42) oligomers Tau protein using different dye-coded polyA aptamer-AuNPs (PAapt-AuNPs) conjugates. This strategy relies on the specific protein–aptamer binding-mediated aggregation AuNPs concomitant plasmonic coupling effect...
Tembusu virus, similar to other mosquito-borne flaviviruses such as WNV, JEV, and BAGV, can be transmitted without the presence of mosquito vectors. We demonstrate that envelope protein TMUV its amino acid (S) at position 156 is responsible for tissue tropism transmission in ducks. The mutation S156P results disruption N-linked glycosylation 154 E changes conformation “150 loop” protein, which induces limited virus replication lungs abrogates between Our findings provide new knowledge about among
ABSTRACT Background Among patients reliant on continuous‐flow (CF) mechanical circulatory support devices, bleeding is primarily caused by an acquired von Willebrand factor (vWF) deficiency, precipitated the high shear stress and diminished pulsatility inherent to these systems. However, despite its clinical significance, relationship between devices' flow modes development of vWF defects remains poorly investigated. Herein, we conducted molecular dynamic (MD) simulations in vivo validation...
A fluorescent assay for detection of OTA based on RCA–activated multisite-CHA dual concurrent strategy.
The goal of net zero carbon emission is a great concern to energy conservation and reduction. In aerospace other industrial fields, one main consumption forms the friction between motion pairs despite that caused by equipment mass cannot be ignored. Therefore, ultra-low density self-lubricating composites with interpenetrating network (IPN) structure-liquid lubricant coupling mechanism designed prepared in this work meet pressing requirement saving liquid situ locked into polyurethane...
In the present work, a simple, rapid, isothermal, and ultrasensitive homogeneous electrochemical biosensing platform for target Hg2+ detection was developed on basis of an exonuclease III (Exo III)-aided recycling amplification strategy. assay, label-free hairpin probe (HP1) ingeniously designed, containing protruding DNA fragment at 3'-termini as recognition unit Hg2+. Also, in loop region 5'-termini (Helper) could be used when secondary analog is introduced, but it caged stem HP1 without...
The self-assembly of plasmonic nanoparticles provides a powerful approach to generate surface-enhanced Raman scattering (SERS), which promotes the actual applications in chemical and biomolecular analyses. Herein, we developed facile SERS sensing strategy for an ATP assay with 3-D DNA nanomachine that walks by Exo III cleavage, leading formation AuNP aggregates, resulted enhancement electromagnetic field. Depending on target-activated can walk along track surface AuNPs self-assembled...
Uracil-DNA glycosylase (UDG) is a crucial damage repair enzyme that initiates the cellular base excision pathway maintains integrity of genome. Abnormal UDG activity may induce malfunction uracil directly related to range diseases including cancers, genotypic diseases, and human immunodeficiencies. In this work, simple, robust cost effective biosensing platform for ultrasensitive detection established based on combination repair-initiated primer generation rolling circular amplification...
MiRNA detection is realized by DNA three-way junction-actuated strand displacement and a fluorescence light-up Ag nanocluster probe.
A live attenuated duck Tembusu virus (TMUV) vaccine FX2010-180P (180P) was successfully utilized to prevent TMUV infections in ducks China. Compared with wild-type TMUV, 180P highly and lost transmissibility ducks. However, the mechanism of attenuation remains poorly understood. To explore key molecular basis attenuation, chimeric site mutant viruses background TMUV-FX2010 (FX) strain were rescued, replication, tissue tropism, characterized The results show that envelope (E) protein...
We have developed an SERS-based platform for the miRNA-21 assay with nucleic acid and Raman dye-modified AuNPs as capture substrates.
Background: The major concerns for patients who have acute lung injury (ALI) or respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 sepsis and undergone successful venovenous extracorporeal membrane oxygenation (VV ECMO) include a low survival rate an uncontrollable inflammatory response. This study aimed to introduce inflammation-related ALI/ARDS rat model supported by VV ECMO that is more suitable clinical application assess the immune response thereby further...