A5005413904- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Memory and Neural Mechanisms
- Forensic Toxicology and Drug Analysis
- Music Therapy and Health
- Receptor Mechanisms and Signaling
- Multiple Sclerosis Research Studies
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Dementia and Cognitive Impairment Research
- Biochemical effects in animals
- Attention Deficit Hyperactivity Disorder
- Neuroscience, Education and Cognitive Function
- COVID-19 and Mental Health
- Thyroid Disorders and Treatments
- Coconut Research and Applications
- Optimism, Hope, and Well-being
Universidad de Zaragoza
2018-2024
Universitat de València
2012-2022
Sapienza University of Rome
2022
Creative Research Enterprises (United States)
2022
Jackson and Tull (United States)
2022
Universitat Jaume I
2018-2019
Universidad Europea
2016-2018
Instituto de Agroquímica y Tecnología de Alimentos
2018
Universidad Europea
2017
Background: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder (mainly in women), and new therapies are needed. In this way, ketone bodies a direct source of cellular energy can be obtained from coconut oil, postulating that oil could non-pharmacological alternative AD patients. Objective: The aim study to detect changes main cognitive functions patients with after following enriched Mediterranean diet, determine whether there differences function stage or sex....
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, ultimately death. There no known cure, the clinical benefit two drugs approved treat ALS remains unclear. Novel disease-modifying therapeutics that are able modulate disease course desperately needed. Our objective was evaluate efficacy tolerability Elysium Health's candidate drug EH301 in...
To evaluate the effectiveness of implementation a short protocol music therapy as tool to reduce stress and improve emotional state in patients with mild Alzheimer's disease.A sample 25 received based on application session lasting 60 min. Before after therapy, patient saliva was collected quantify level salivary cortisol using Enzyme-Linked ImmunoSorbent Assay (ELISA) immunoassay technique questionnaire completed measure anxiety depression (Hospital Anxiety Depression Scale).The results...
A novel approach to reduce the incidence of substance use disorders is promote resilience stress using environmental resources such as physical exercise. In present study we test hypothesis that Voluntary Wheel Running (VWR) during adolescence blocks negative consequences induced by intermittent repeated social defeat (IRSD). Four groups adolescent male C57BL/6 mice were employed in experiment; two exposed VWR (1 h, 3 days/week) from postnatal day (PND) 21 until first (PND 47), while...
Introduction. Multiple sclerosis (MS) is a neurodegenerative disease that, despite mainly affecting women, more severe in men and causes motor, cognitive emotional alterations. The objective of this study was to determine the possible relationship between Materials Methods. This descriptive, observational cross-sectional study, with 67 patients MS (20 47 women), who were given following questionnaires: Expanded Disability Status Scale (EDSS), Two-Minute Walk Test (2MWT), Berg Balance Scale,...
Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice rewarding effects cocaine in conditioned place preference (CPP) paradigm. According "inoculation stress" hypothesis, a brief period maternal separation (MS) can provide protection against negative IRSD. The aim present study was assess whether exposure episode MS prevents subsequent short-term IRSD on depression- and anxiety-like behaviors explore its long-term CPP mice. Four groups male C57BL/6 were...
Exposure to social defeat stress increases the rewarding effects of psychostimulants in animal models, but its effect on 3,4-methylenedioxymethylamphetamine (MDMA) reward has received little attention. In present study, we evaluated influence MDMA adolescent [postnatal day (PND) 29-40] and adult (PND 50-61) male mice using conditioned place preference paradigm. Experimental were exposed an agonistic encounter before each session conditioning with 1.25 or 10 mg/kg MDMA. The corticosterone...
Some 3,4-methylenedioxymethamphetamine (MDMA) users become dependent as a result of chronic consumption. A greater understanding the neurobiological basis rewarding effects MDMA could contribute to developing effective pharmacotherapies for MDMA-related problems. The present study evaluated role N-methyl-D-aspartate (NMDA) glutamate receptors (NMDARs) in acquisition and reinstatement conditioned place preference (CPP) induced by MDMA. Adolescent male mice were with 1 or 10 mg/kg pretreated 5...
Exposure to social stress alters the response drugs of abuse experimental animals. Changes in glutamatergic system seem play a role effects defeat on rewarding properties cocaine and amphetamine. The aim present study was evaluate involvement N-methyl-D-aspartate (NMDA) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors conditioned place preference induced by 3,4-methylenedioxymethamphetamine (MDMA). Our hypothesis that changes these could mediate MDMA reward....
Background: Alzheimer's disease is the most common neurodegenerative disorder in our society, mainly characterized by loss of cognitive function. However, other symptoms such as anxiety and depression have been described patients. The process mediated alterations synaptic extrasynaptic activity neurotransmitter glutamate, which are linked to a hypometabolism glucose main source brain energy. In that respect, Ketogenic diet (KD) has proposed non-pharmacological treatment serving an...
The understanding of how the immune system works, as well its relationship with stress level, seems to be important at start Alzheimer's disease (AD). To analyze this, immunoglobulin A (IgA) and cortisol in saliva were measured using ELISA patients mild AD healthy volunteers, production both biomarkers was compared correlated. In participants without AD, IgA higher when lower, opposite happened quantification being a suitable method determine it.
The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced cocaine in mice. phenomenon of resilience understood as ability subjects to overcome negative effects focus increasing interest. Our aim characterize behavior resilient animals with respect RSD on CPP cocaine. To this end, 25 male C57BL/6 mice were exposed during late adolescence, while other 15 did not undergo (controls)....
(1) Background: Multiple sclerosis (MS) is pathogenically characterized by high oxidative stress and symptomatically progressive muscle loss increased body fat associated with the presence of depression. Epigallocatechin gallate (EGCG) (particularly present in green tea) ketone bodies (in particular beta-hydroxybutyrate (BHB)), whose main source coconut oil, have shown emotional benefits loss. The aim this study was to assess impact EGCG oil on cortisol activity related depression MS...