A5022530132- Sulfur Compounds in Biology
- Sirtuins and Resveratrol in Medicine
- Amino Acid Enzymes and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Redox biology and oxidative stress
- Metabolism and Genetic Disorders
- Neurogenetic and Muscular Disorders Research
- Bioactive natural compounds
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Skin Protection and Aging
- Folate and B Vitamins Research
- Toxin Mechanisms and Immunotoxins
- Phytochemicals and Antioxidant Activities
- Ultrasound and Hyperthermia Applications
Universitat de València
2016-2025
Parc Científic de la Universitat de València
2013-2015
Institut d'Investigacions Biomèdiques de Barcelona
2001-2003
Universidad Cardenal Herrera CEU
2002
Zambon (Italy)
2001
Zambon (Spain)
2001
Universidad Complutense de Madrid
1986
University of Amsterdam
1985
Heinrich Heine University Düsseldorf
1981
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; cell proliferation death. The intracellular thiol redox state (controlled by one endogenous effectors involved regulating mitochondrial permeability transition pore complex and, consequence, oxidation can be a causal factor mitochondrion-based mechanism that leads to...
Mitochondrial damage may be a major cause of cellular aging. So far, this hypothesis had only been tested using isolated mitochondria. The aim study was to investigate the involvement mitochondria in aging whole liver cells and not only. Using flow cytometry, we found that age is associated with decrease mitochondrial membrane potential (30%), an increase size, peroxide generation (23%). Intracellular levels were also increased. number per cell inner mass did change. Gluconeogenesis from...
1. Ethanol induces a decrease in GSH (reduced glutathione) concentration is isolated hepatocytes. Maximal effects appear at 20 mM-ethanol. The concentration-dependence of this paralleled by the activity alcohol dehydrogenase. 2. Pyrazole, specific inhibitor dehydrogenase, prevents ethanol-induced depletion. 3. Acetaldehyde, above 0.05 mM, also promotes 4. Disulfiram (0.05 mM), an aldehyde potentiates fall caused acetaldehyde. 5. findings support hypothesis that acetaldehyde responsible for...
The aim of this study is to evaluate possible harmful effects high doses t-pterostilbene (t-PTER) and quercetin (QUER) in Swiss mice. Mice were fed during 28 days at 0, 30, 300, 3000 mg/kg body weight/day t-PTER, QUER, or a mixture both, t-PTER + which are equivalent 5, 50, 500 times, respectively, the estimated mean human intake these polyphenols (25 mg/day). Daily oral administration both them did not cause mortality experimental period. There no differences food water consumption on sex....
Natural polyphenols are organic chemicals which contain phenol units in their structures. They show antitumor properties. However, a key problem is short half-life and low bioavailability under vivo conditions. Still, definitively demonstrating the human benefits of isolated polyphenolic compounds (alone or combination) using modern scientific methodology has proved challenging. The most common discrepancy between experimental clinical observations use nonphysiologically relevant...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, ultimately death. There no known cure, the clinical benefit two drugs approved treat ALS remains unclear. Novel disease-modifying therapeutics that are able modulate disease course desperately needed. Our objective was evaluate efficacy tolerability Elysium Health's candidate drug EH301 in...
Inhibition of cancer growth by resveratrol (trans-3,5,4'trihydroxystilbene; RESV), a phytoalexin present in many plant species, is limited its low bioavailability. Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene; PTER) and quercetin (3,3',4',5,6-pentahydroxyflavone; QUER), two structurally related naturally occurring small polyphenols, show longer half-life vivo. In vitro highly malignant B16 melanoma F10 cells (B16M-F10) inhibited (56%) short-time exposure (60 min/day) to PTER (40 μM) QUER...