A5056627862- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Peroxisome Proliferator-Activated Receptors
- Complement system in diseases
- Pharmacological Receptor Mechanisms and Effects
- Blood transfusion and management
- Bone health and osteoporosis research
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Impact on Reproduction
- COVID-19 and Mental Health
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Oral and gingival health research
- HIV/AIDS drug development and treatment
- X-ray Diffraction in Crystallography
- Hemostasis and retained surgical items
- Peptidase Inhibition and Analysis
- Vitamin D Research Studies
- COVID-19 epidemiological studies
- Atrial Fibrillation Management and Outcomes
- Vitamin K Research Studies
- Parathyroid Disorders and Treatments
Albert Einstein College of Medicine
2020-2024
Rhode Island Hospital
2011-2023
Providence College
1995-2023
Brown University
2008-2022
Stony Brook University
2015-2019
Royal College of Surgeons in Ireland
2017
Belfast City Hospital
2014
University of Ulster
2014
University of Ottawa
2011
NHS Blood and Transplant
2011
Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) occur naturally in marijuana (Cannabis) may be formulated, individually or combination pharmaceuticals such as Marinol Sativex. Although it is known that these hydrophobic compounds can transported blood by albumin lipoproteins, the intracellular carrier has not been identified. Recent reports suggest CBD THC elevate levels of endocannabinoid anandamide (AEA) when administered to humans, suggesting phytocannabinoids target cellular proteins...
The efficacy of convalescent plasma (CP) for the treatment coronavirus disease 2019 (COVID-19) remains unclear. In a matched cohort analysis hospitalized patients with severe COVID-19, impact CP on in-hospital mortality was evaluated using univariate and multivariate Cox proportional-hazards models, time to hospital discharge assessed stratified log-rank analysis. total, 64 who received median 7 days after symptom onset were compared control group 177 patients. incidence 12.5% 15.8% in...
Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for 2019 (COVID-19). We compared the mortality and clinical outcome of patients COVID-19 who received 200 mL CCP spike protein IgG titer ≥ 1:2430 (median 1:47,385) within 72 hours admission propensity score-matched controls cared at medical center in Bronx, between April 13 May 4, 2020. Matching criteria were age, sex, body mass index, race, ethnicity,...
Abstract Background The efficacy of convalescent plasma (CP) for the treatment COVID-19 remains unclear. Methods A matched cohort analysis hospitalized patients with severe COVID-19. impact CP on all cause in-hospital mortality was evaluated using univariate and multivariate Cox proportional-hazards models, time to hospital discharge assessed a stratified log-rank analysis. Results 64 who received median 7 days after symptom onset were compared control group 177 patients. Overall 14.9%....
Abstract Novel coronavirus disease 2019 (COVID‐19) is a highly infectious, rapidly spreading viral that typically presents with greater severity in patients underlying medical conditions or those who are immunosuppressed. We present novel case series of three kidney transplant recipients COVID‐19 recovered after receiving convalescent plasma (CCP) therapy. Physicians should be aware this potentially useful treatment option. Larger clinical registries and randomized trials conducted to...
Abstract The causes of coagulopathy associated with coronavirus disease 2019 (COVID-19) are poorly understood. We aimed to investigate the relationship between von Willebrand factor (VWF) biomarkers, intravascular hemolysis, coagulation, and organ damage in COVID-19 patients study their association severity mortality. conducted a retrospective 181 hospitalized randomly selected balanced distribution survivors nonsurvivors. Patients who died had significantly lower ADAMTS13 (a disintegrin...
ABSTRACT The causes of coagulopathy associated with COVID-19 disease are poorly understood. We aimed to investigate the relationship between markers endothelial activation, intravascular hemolysis, coagulation, and organ damage in patients study their association severity mortality. conducted a retrospective 181 hospitalized randomly selected equal distribution survivors non-survivors. Patients who died had significantly lower ADAMTS13 activity, higher LDH, schistocytes von Willebrand Factor...
Abstract The increasing use of medical marijuana highlights the importance developing a better understanding cannabinoid metabolism. Phytocannabinoids, including ∆ 9 -tetrahydrocannabinol (THC), are metabolized and inactivated by cytochrome P450 enzymes primarily within liver. lipophilic nature cannabinoids necessitates mechanism(s) to facilitate their intracellular transport metabolic enzymes. Here, we test central hypothesis that liver-type fatty acid binding protein (FABP1) mediates...
BACKGROUND: In the SToP platelet dose study, World Health Organization (WHO) bleeding grade was assigned using adjudication. This study describes challenges associated with adjudicating events and compares adjudicated bedside results for grade. STUDY DESIGN AND METHODS: To categorize bleeding, following information provided to adjudicators: daily assessments, interventions stop or control blood counts, transfused components. Each assessment sent two adjudicators who independently a anatomic...
Fatty acid binding protein 5 (FABP5) is a promising target for development of inhibitors to help control pain and inflammation. In this work, computer-based docking (DOCK6 program) was employed screen ∼2 M commercially available compounds FABP5 based on an X-ray structure complexed with the small molecule inhibitor SBFI-26 previously identified by our group (also through virtual screening). The goal discovery additional chemotypes. resulted in purchase 78 candidates, which led identification...
Abstract Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients COVID-19 who received 200mL CCP a Spike protein IgG titer ≥1:2,430 (median 1:47,385) within 72 hours admission to propensity score-matched controls cared at medical center in Bronx, between April 13 May 4, 2020. Matching criteria were age, sex, body mass...
Abstract Lipocalin‐type prostaglandin D synthase (L‐PGDS; EC:5.3.99.2) is an enzyme with dual functional roles as a 2 ‐synthesizing and extracellular transporter for diverse lipophilic compounds in the cerebrospinal fluid (CSF). Transport of hydrophobic endocannabinoids mediated by serum albumin blood intracellularly fatty acid binding proteins, but no analogous transport mechanism has yet been described CSF. L‐PGDS reported to promiscuously bind wide variety ligands among most abundant...
SARS-CoV-2 (COVID-19) infection is associated with acute ischemic stroke (AIS), which may be due to a prothrombotic state. Early reports have suggested high rates of reocclusion following mechanical thrombectomy (MT) poor radiographic and clinical outcomes. We report our early experience using intra-procedural antithrombotics address reocclusion. identified 6 patients that experienced after MT for COVID-19-associated AIS through retrospective chart review abstracting their basic...
Abstract Systemic inflammation and coagulopathy are characteristic hallmarks of COVID19. “COVID coagulopathy” manifests mainly as a prothrombotic state affecting both large small blood vessels, presenting arterial, venous, microangiopathic thrombotic events with von Willebrand factor (VWF) soluble thrombomodulin increased in hospitalized patients. The causes poorly understood. Aim: To investigate the relationship between biomarkers, intravascular hemolysis, coagulation, organ damage COVID19...
<h3>Objectives</h3> Measure bone turnover markers (BTM) CTx, P1NP and bone-specific alkaline phosphatase (BsALP) in a severe asthma population using systemic corticosteroids (SCS). Assess mineral density (BMD) change regional clinics. <h3>Background</h3> Severe often requires regular SCS use. cause several adverse effects including reduced metabolism; resorption is increased formation decreased resulting osteoporosis. DXA scans monitor BMD the hip spine every 3–5 years. decrease treated with...
Journal of the American Society Nephrology 33(11S):p 93-94, November 2022. | DOI: 10.1681/ASN.20223311S193d