A5100452983- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Fungal Infections and Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- FOXO transcription factor regulation
- Ovarian cancer diagnosis and treatment
- Magnesium Alloys: Properties and Applications
- Antifungal resistance and susceptibility
- Occupational and environmental lung diseases
- Angiogenesis and VEGF in Cancer
- Bone Tumor Diagnosis and Treatments
- Corrosion Behavior and Inhibition
- Analytical Chemistry and Chromatography
- Ultrasound and Hyperthermia Applications
Central Hospital of Zibo
2025
Fudan University Shanghai Cancer Center
2009-2024
Shanghai Medical College of Fudan University
2009-2023
Third People's Hospital of Hefei
2023
Xian Yang Central Hospital
2023
Kunming Medical University
2022-2023
First Affiliated Hospital of Kunming Medical University
2022-2023
Shandong First Medical University
2022
Guangdong Provincial People's Hospital
2022
Jinan Central Hospital
2022
Mg-3wt%Al anodes with Sn, Ga and In were prepared by melting heat-treatment in electric resistance furnace. The electrochemical discharge behavior of these 3.5wt% NaCl solutions was studied potentiodynamic polarization impedance spectroscopy (EIS). microstructures the corroded surfaces investigated scanning electron microscopy (SEM) energy dispersive spectrometer (EDS). Finally, Mg-air batteries based on Mg-3Al-1Sn (AS31), Mg-3Al-1Ga (AG31), Mg-3Al-1In (AI31) alloys battery properties...
// Haiyong Wang 1, 2, * , Chenyue Zhang 3, Litao Xu 3 Kun Zang Zhouyu Ning Feng Jiang 4 Huiying Chi 5 Xiaoyan Zhu Zhiqiang Meng 1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 200032, China 2 Radiation Shandong Hospital & Institute, Jinan, 250117, Medical College, University, Zhucheng TCM, 262200, Geriatric Institute Chinese Medicine, Longhua Hospital, Traditional 200031, These authors contributed equally to this work Correspondence to: Zhu, e-mail:...
Human breast cancers include cancer stem cell populations as well non-tumorigenic cells. Breast cells possess self-renewal capability and thus are the root cause of recurrence metastasis malignant tumors. Hypoxia is a fundamental pathological feature solid tumor tissues exerts wide range effects on biological behavior However, there little information role hypoxia in modulating stemness In present study, we cultured MDA-MB-231 hypoxic gas mixture to simulate environment determine how...
Sorafenib, an antiangiogenic agent, can promote tumor invasion and metastasis. The phosphatidylinositol 3-kinase (PI3K)/Akt/Snail-dependent pathway plays important role in Yet, little is known concerning the of PI3K/Akt/Snail-dependent sorafenib‑induced metastasis hepatic carcinoma (HCC). A human HCC orthotopic xenograft model was established, sorafenib (30 mg/kg/day) administered orally. Tumor growth intrahepatic were assessed, immunohistochemistry applied to analyze activation pathway....
Wilms tumor 1-associated protein (WTAP) has been validated to be a crucial regulator in the tumorigenesis and advancement of diverse malignancies. This study intended probe impacts WTAP on colorectal cancer (CRC) progression from perspective N6-methyladenosine (m6A) modification. The differential expression patterns clinical CRC samples cultured cell lines were via qRT-PCR western blot. Cell function tests conducted with colony formation, transwell, CCK-8. MeRIP-qPCR was identify...
Sorafenib mainly exerts its anti-hepatoma effect by inhibiting tumor angiogenesis. However, curative is limited. Thus, application of drugs which could augment anti-angiogenic necessary. Bufalin has been reported to possess anticancer properties. In the present study, we investigated synergistic sorafenib combined with bufalin. The enhanced combination treatment was firstly assessed in nude mice bearing human HCC intradermal tumors. addition, found that proliferation significantly inhibited...
Cancer stem cells (CSCs) are important in cancer, as these possess enhanced tumor-forming capabilities and resistant to current anticancer therapies. Agents with the ability suppress CSCs likely provide novel opportunities for combating tumor proliferation metastasis. The present study aimed evaluate effects of bufalin on pancreatic vivo vitro. Using a serum‑free suspension culture, spheres were enriched gemcitabine‑resistant human cancer cell line, which had higher percentage CSCs, western...
In this paper, a facile solvothermal synthesis method was developed to prepare monodisperse magnetites anchored onto multi-walled carbon nanotubes (MWNTs). The pristine MWNTs were treated with mixture of concentrated sulfuric and nitric acids. oxidized (o-MWNTs) had abundant carboxylic groups on the surface, which have strong ability chelate metal ions like Fe3+. obtained MWNTs–Fe3O4 nanomaterials allowed π–π stacking fluorescein isothiocyanate (FITC) monitor inside living cancer cells by...
Hemorrhagic transformation, especially symptomatic intracranial hemorrhage (sICH), is a common complication after mechanical embolectomy. This study explored grading scale based on clinical and radiological parameters to predict sICH embolectomy.Demographic data were retrospectively collected from patients with acute ischemic stroke treated embolectomy at West China Hospital. Clinical factors associated identified used develop the "STBA" scale. score was then validated using an independent...
Biliary tract cancer (BTC) is an aggressive malignancy with few options for advanced-stage treatment. The combination of PD-1/PD-L1 inhibitors famitinib, a receptor tyrosine kinase (RTK) inhibitor, has demonstrated improved clinical outcomes in several trials. We herein reported case gallbladder (GBC) patient liver metastases, previously resistant to traditional chemotherapy. Remarkably, the achieved complete response (CR) long-lasting survival benefit exceeding 3 years. This was using novel...
// Qiwen Chen 1,2,* , Zhouyu Ning 1,* Lei Wang 3,* Haifeng Ying 4,* Shu Dong Chenyue Zhang Xiaoheng Shen 4 Yuanbiao Guo Hao 1 Xiaoyan Zhu Yehua Weidong Shi Yongqiang Hua Kun Junhua Lin Litao Xu Lianyu Lanyun Feng Xiumei Jing Xie Bo Sun 5 Yaqin 6 Wenchao Gu Mei Kang 2 Zheng Tang Zhujun 7 Zhen Luming Liu Jinming Yu Zhaoshen Li 3 and Zhiqiang Meng Department of Integrative Oncology Oncology, Fudan University, Shanghai Cancer Center, Medical College, Shanghai, China Institute Clinical...
A multitargeting drug delivery system based on micelles modified with urokinase-type plasminogen activator-sensitive activated cell-penetrating peptides (uPA-ACPP) for the treatment of brain glioma is first developed. Compared conventional polyethylene glycol-poly(lactic acid) nanoparticles, smaller size, higher loading are more suitable tumor under action uPA-sensitive ACPP. As a service to our authors and readers, this journal provides supporting information supplied by authors. Such...
Cryptococcus neoformans sequence type 5 (ST5) lineage could infect immunocompetent hosts and cause a significant medical burden. We sought to identify characteristics prognostic risk factors of ST5 lineage-associated cryptococcosis.Multilocus typing antifungal susceptibility testing were conducted for isolates. The clinical laboratory cryptococcosis patients investigated. multivariable logistic regression identified variables independently associated with 30-day mortality in without HIV.The...
Abstract Advanced biliary tract cancer (BTC) and pancreatic ductal adenocarcinoma (PDAC) have poor prognoses limited treatment options. Here, we conducted this first-in-class phase II study to evaluate the efficacy safety of SHR-1701, a bifunctional fusion protein targeting programmed death-ligand 1 (PD-L1) transforming growth factor-beta (TGF-β), combined with famitinib, multi-targeted receptor tyrosine kinase inhibitor, in patients advanced BTC or PDAC who failed previous standard (trial...
Background Primary Ewing’s sarcoma of sphenoid sinus, observed in children and adolescents, is an extremely rare malignancy. Such rarity makes the imaging features treatment strategies for sinus unclear. This study aimed to offer guidance treating this very disease by describing a patient with primary reviewing available data literature. Case description A case treated multidisciplinary approaches, including tumor resection, radiotherapy, chemotherapy, antiangiogenic therapy, was presented...
To analyze radiological characteristics of Muller-Weiss disease, evaluate the clinical value imaging examination in diagnosis disease.The data 26 patients with disease were collected from September 2015 to August 2020, including 7 males and 19 females, aged 43 68 years old an average (52.7±4.6) old. In X-ray observed shape position navicular bone. The talar-first metatarsal angle(TFM) was measured on weight-bearing anteroposterior radiograph. arch angle between mid-axis talus first...