A5033336054- Epigenetics and DNA Methylation
- Immune cells in cancer
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- RNA Interference and Gene Delivery
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
Translational Research in Oncology
2022
Hebrew University of Jerusalem
2011-2014
Weizmann Institute of Science
2012-2013
Abstract Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both animal models human diseases such as idiopathic fibrosis (IPF). IPF a detrimental interstitial disease, although two approved drugs limit functional decline, transplantation the only treatment that extends survival, highlighting need regenerative therapies. Methods Using our antibody-based...
NK cells rapidly kill tumor cells, virus infected and even self cells. This is mediated via killer receptors, among which NKp46 (NCR1 in mice) prominent. We have recently demonstrated that type 1 diabetes (T1D) accumulate the diseased pancreas they manifest a hyporesponsive phenotype. In addition, we found recognizes an unknown ligand expressed by beta derived from humans mice blocking of activity prevented development. Here investigated properties ligand. show mainly located insulin...
Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that EHMT2 methyltransferase regulates signaling the lung by controlling transcriptional activity of chromatin-bound β-catenin, through a non-histone substrate mouse lung. Inhibition induces transcriptional, morphologic, molecular changes consistent with alveolar type 2 (AT2) lineage commitment. Mechanistically, functions to support regenerative...
Abstract Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that G9a methyltransferase regulates signaling the lung by controlling transcriptional activity of chromatin-bound β-catenin, through a non-histone substrate. Inhibition induces transcriptional, morphologic, molecular changes consistent with alveolar type 2 (AT2) lineage commitment. Mechanistically, functions to support regenerative...