A5043916697- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Uterine Myomas and Treatments
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Gynecological conditions and treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- COVID-19 and healthcare impacts
- Organ Transplantation Techniques and Outcomes
- Lymphoma Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Metabolism and Genetic Disorders
- Nonmelanoma Skin Cancer Studies
- Ovarian function and disorders
- Cancer survivorship and care
- Inflammatory Myopathies and Dermatomyositis
- Gastric Cancer Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- Assisted Reproductive Technology and Twin Pregnancy
The Royal Free Hospital
2014-2025
University College London
2014-2025
University of Southern California
2013-2024
LAC+USC Medical Center
2020-2023
Southern California University for Professional Studies
2022
Roland Hill (United Kingdom)
2014
Hyperammonemia is common in liver cirrhosis and causally associated with hepatic encephalopathy development. Little known about its hepatotoxic effects, which we aimed to characterize this study. In a mouse model of chronic hyperammonemia without preexisting disease, observed development fibrogenesis necroptotic cell death. also induced dysregulation main metabolic pathway, the urea cycle, as reflected by down-regulation cycle enzyme protein expression accumulation metabolites. Inhibition...
Abstract Purpose: High-grade serous ovarian carcinoma (HGSOC) is the most lethal epithelial cancer (EOC) and often diagnosed at late stage. In women with a known pelvic mass, surgery followed by pathologic assessment reliable way to diagnose EOC there are still no effective screening tools in asymptomatic women. current study, we developed cell-free DNA (cfDNA) methylation liquid biopsy for risk of early-stage HGSOC. Experimental Design: We performed reduced representation bisulfite...
Abstract Epithelial ovarian cancer (EOC) is a malignancy associated with considerable morbidity and high rates of mortality, primarily due to its frequent presentation in an advanced stage. High grade serous carcinoma (HGSOC) the most lethal gynecologic malignancy, 5-year survival rate 40% or less when diagnosed at late-stage. There currently no single effective screening tool for risk community-based assessment HGSOC. In women known pelvic mass, surgery followed pathological only definitive...
Abstract High-grade serous ovarian cancer (HGSC) is the most common and aggressive subtype of epithelial cancer. Importantly, germline mutations in BRCA1/2 give rise to HGSC. Because HGSC are diagnosed at stage III/IV, outcomes poor more effective therapies needed. Although immune checkpoint inhibitors show promise for a number types, efficacy has been variable To help provide new clues molecular features HGSC, we set out elucidate tumor microenvironment using spatial transcriptomics...
• Immune checkpoint inhibitors are approved for all mismatch repair deficient tumors. Although rare, autoimmune myositis complicating pembrolizumab therapy may be fatal. In this case, caused rhabdomyolysis but also a durable response. Severe reaction associated with treatment
Abstract Background and Objectives Low anterior rectosigmoid resection for a gynecologic disease is usually performed in concert with other procedures can result significant morbidity should anastomotic complication occur. This study examined surgical outcomes of side‐to‐end reanastomosis after low (STELAR) by oncology service. Methods case series examining consecutive patients who underwent STELAR indications single group from 2009 to 2018. Prospectively collected institutional database was...
Abstract Ovarian cancer (OvCa) is the deadliest gynecological malignancy in United States. Surgery and chemotherapy are primary treatments for OvCa, but 80% of late-stage OvCa patients experience chemo-resistant recurrence, which necessitates development new treatment strategies. The genomic diversity within a tumor interactions among various cell types its microenvironment considered key factors contributing to therapeutic efficacy. Specifically, women who harbor germline BRCA1 or BRCA2...
<div>AbstractPurpose:<p>High-grade serous ovarian carcinoma (HGSOC) is the most lethal epithelial cancer (EOC) and often diagnosed at late stage. In women with a known pelvic mass, surgery followed by pathologic assessment reliable way to diagnose EOC there are still no effective screening tools in asymptomatic women. current study, we developed cell-free DNA (cfDNA) methylation liquid biopsy for risk of early-stage HGSOC.</p>Experimental Design:<p>We performed...
<p>Figure S5: OvaPrint™ analysis of stage IV HGSOC plasma samples</p>