A5083227282- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Boron Compounds in Chemistry
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Analytical Chemistry and Sensors
- Monoclonal and Polyclonal Antibodies Research
- Polymer Surface Interaction Studies
- Peptidase Inhibition and Analysis
- Surfactants and Colloidal Systems
- Luminescence and Fluorescent Materials
- Radiopharmaceutical Chemistry and Applications
- Protein Structure and Dynamics
- Supramolecular Self-Assembly in Materials
- Organoboron and organosilicon chemistry
- Graph theory and applications
- Catalytic Alkyne Reactions
- Machine Learning in Materials Science
- Supramolecular Chemistry and Complexes
- Membrane-based Ion Separation Techniques
- Topological and Geometric Data Analysis
- Biosensors and Analytical Detection
- Membrane Separation Technologies
University of Delaware
2022-2025
University of California, Berkeley
2021-2023
California NanoSystems Institute
2016-2020
University of California, Los Angeles
2016-2020
Los Angeles City College
2017-2020
University of California System
2019
Texas A&M University – Corpus Christi
2013-2016
An efficient method for chemoselective cysteine arylation of unprotected peptides and proteins using Au(III) organometallic complexes is reported. The bioconjugation reactions proceed rapidly (<5 min) at ambient temperature in various buffers within a wide pH range (0.5–14). This approach provides access to diverse array S-aryl bioconjugates including fluorescent dye, complex drug molecule, affinity label, poly(ethylene glycol) tags, stapled peptide. A library reagents can be prepared as...
We report the first observed Pd-catalyzed isomerization ("cage-walking") of B(9)-bromo-meta-carborane during cross-coupling, which enables formation B-O and B-N bonds at all boron vertices (B(2), B(4), B(5), B(9)) meta-carborane. Experimental theoretical studies suggest this mechanism is strongly influenced by steric crowding Pd catalyst either a biaryl phosphine ligand and/or substrate. Ultimately, "cage-walking" process provides unique pathway to preferentially introduce functional groups...
We report a discovery that perfunctionalized icosahedral dodecaborate clusters of the type B12(OCH2Ar)12 (Ar = Ph or C6F5) can undergo photo-excitation with visible light, leading to new class metal-free photooxidants. Excitation in these species occurs as result charge transfer between low-lying orbitals located on benzyl substituents and an unoccupied orbital delocalized throughout boron cluster core. Here we show how species, photo-excited benchtop blue LED source, exhibit excited-state...
Reactive oxygen species (ROS) like hydrogen peroxide (H2O2) are transient that have broad actions in signaling and stress, but spatioanatomical understanding of their biology remains insufficient. Here, we report a tandem activity-based sensing labeling strategy for H2O2 imaging enables capture permanent recording localized fluxes. Peroxy Green-1 Fluoromethyl (PG1-FM) is diffusible small-molecule probe senses by boronate oxidation reaction to trigger dual release covalent fluorescent...
Copper is an essential nutrient for sustaining vital cellular processes spanning respiration, metabolism, and proliferation. However, loss of copper homeostasis, particularly misregulation loosely bound ions which are defined as the labile pool, occurs in major diseases such cancer, where tumor growth metastasis have a heightened requirement this metal. To help decipher role etiology we report histochemical activity-based sensing approach that enables systematic, high-throughput profiling...
Proteins are modified with small molecules and polymers via olefin metathesis reactions in aqueous media.
Polymers with different trehalose side chain regioisomers were synthesized and compared for insulin stabilization.
Bioconjugation techniques for biomolecule–polymer conjugation are numerous; however, slow kinetics and steric challenges generally necessitate excess reagents or long reaction times. Organometallic transformations known to circumvent these issues; yet, harsh conditions, incompatibility in aqueous media, substrate promiscuity often limit their use a biological context. The work reported herein demonstrates facile benign organometallic Au(III) S-arylation approach that enables the synthesis of...
Stimuli-responsive membranes that enable the smart control of membrane transport properties represent an interesting class materials for a wide range separation processes. In this work, surface-initiated, electrochemically mediated atom transfer radical polymerization was used to grow poly(acrylic acid) brushes from surface percolating network carbon nanotubes coating ultrafiltration membrane. Brush molecular weights as high 930 kDa were achieved, with very low dispersivity. When no...
Carborane RAFT agents are introduced as tunable multi-purpose tools acting <sup>1</sup>H NMR spectroscopic handles, Raman probes, and recognition units.
Redox-active proanions of the type B12(OCH2Ar)12 [Ar = C6F5 (1), 4-CF3C6H4 (2), 3,5-(CF3)2C6H3 (3)] are introduced in context an experimental and computational study visible-light-initiated polymerization a family styrenes. Neutral, air-stable 1-3 were found to initiate styrene through single-electron oxidation under blue-light irradiation, resulting polymers with number-average molecular weights (Mn) ranging from ∼6 100 kDa. Shorter polymer products observed majority experiments, except...
By incorporating the concepts of structural preorganisation and complementarity in concert with non-covalent donor-acceptor [ππ] hydrophobic interactions, a duo π-electron deficient bipyridinium-based linear gemini amphiphiles capable responding to molecular templation have been designed synthesised. When combined rich di(ethylene glycol)-disubstituted 1,5-dihydroxynaphthalene, dramatic decrease critical aggregation concentration by ≈66% was observed concomitant increases hydrodynamic...
Multivalent protein-protein interactions serve central roles in many essential biological processes, ranging from cell signaling and adhesion to pathogen recognition. Uncovering the rules that govern these intricate is important not only basic biology chemistry but also applied sciences where researchers are interested developing molecules promote or inhibit interactions. Here we report synthesis application of atomically precise inorganic cluster nanomolecules consisting an core a...
Reversible template-directed micellar-size and shape modulation by virtue of host-guest reversible docking molecular templates at the micellar-solvent interface was achieved in water. By combining a π-electron deficient bipyridinium-based gemini amphiphile which is capable binding aligning with rich tri(ethylene glycol)-disubstituted 1,5-diaminonaphthalene, switchable detergent system operates through pH-responsive formation bisammonium dications realised. The 1,5-diaminonaphthalene guest to...
Multivalent protein-protein interactions serve central roles in many essential biological processes, ranging from cell signaling and adhesion to pathogen recognition. Uncovering the rules that govern these intricate is important not only basic biology chemistry, but also applied sciences where researchers are interested developing molecules promote or inhibit interactions. Here we report synthesis application of atomically precise inorganic cluster nanomolecules consisting an core a...